Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 15, 2024
Abstract
The
treatment
of
brain
diseases
has
always
been
the
focus
attention.
Due
to
presence
blood‐brain
barrier
(BBB),
most
small
molecule
drugs
are
difficult
reach
brain,
leading
undesirable
therapeutic
outcomes.
Recently,
nanomedicines
that
can
cross
BBB
and
precisely
target
lesion
sites
have
emerged
as
thrilling
tools
enhance
early
diagnosis
treat
various
intractable
disorders.
Extensive
research
shown
reactive
oxygen
species
(ROS)
play
a
crucial
role
in
occurrence
progression
diseases,
including
tumors
neurodegenerative
(NDDs)
such
Alzheimer's
disease,
Parkinson's
stroke,
or
traumatic
injury,
making
ROS
potential
target.
In
this
review,
on
structure
function
well
mechanisms
first
elaborated
through
which
nanomedicine
traverses
it.
Then,
recent
studies
production
summarized
photodynamic
therapy
(PDT),
chemodynamic
(CDT),
sonodynamic
(SDT)
for
treating
tumors,
depletion
NDDs.
This
provides
valuable
guidance
future
design
ROS‐targeted
disease
treatment.
ongoing
challenges
perspectives
developing
nanomedicine‐based
management
also
discussed
outlined.
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 267 - 267
Published: April 4, 2025
The
growing
field
of
nanotechnology
has
recently
given
much
attention
to
nanogels,
which
are
versatile
formulas
and
have
promising
biomedical
applications.
Nanogels
or
nanohydrogels
undergone
significant
development
in
various
fields
industrial
research
meet
increasing
demands,
such
as
pharmaceuticals,
cosmetics,
food,
genetic
engineering.
that
contain
flavonoids,
secondary
metabolites
found
plants,
starting
become
distinctive
reveal
their
unique
characteristics.
objective
the
article
is
provide
a
comprehensive
overview
recent
articles
on
flavonoid-based
emphasizing
general
aspects
regarding
nanogel
formulation
structural
characterization,
well
advancements
made
field.
In
conclusion,
this
outlines
up-to-date
developments
synthesis,
formulation,
therapeutic
applications
important
role
nanotechnology.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1162 - 1162
Published: Sept. 3, 2024
Despite
various
methods
currently
used
in
cancer
therapy,
breast
remains
the
leading
cause
of
morbidity
and
mortality
worldwide.
Current
therapeutics
face
limitations
such
as
multidrug
resistance,
drug
toxicity
off-target
effects,
poor
bioavailability
biocompatibility,
inefficient
delivery.
Nanotechnology
has
emerged
a
promising
approach
to
diagnosis,
imaging,
therapy.
Several
preclinical
studies
have
demonstrated
that
compounds
nanoparticles
formulated
from
platinum
group
metals
(PGMs)
effectively
treat
cancer.
PGMs
are
chemically
stable,
easy
functionalise,
versatile,
tunable.
They
can
target
hypoxic
microenvironments,
catalyse
production
reactive
oxygen
species,
offer
potential
for
combination
PGM
be
incorporated
with
anticancer
drugs
improve
efficacy
attached
targeting
moieties
enhance
tumour-targeting
efficiency.
This
review
focuses
on
therapeutic
outcomes
metal
(PGMNs)
against
cells
briefly
discusses
clinical
trials
these
treatment.
It
further
illustrates
applications
PGMNs
presents
opportunities
future
PGM-based
nanomaterial
combatting
Case Studies in Thermal Engineering,
Journal Year:
2024,
Volume and Issue:
57, P. 104326 - 104326
Published: March 31, 2024
This
paper
investigates
the
solubility
behavior
of
digitoxin
in
supercritical
carbon
dioxide
(CO2)
through
a
comprehensive
analysis
employing
ensemble
learning
techniques
and
various
regression
models.
The
dataset
consists
temperature
pressure
as
input
variables,
with
solvent
density
output
variables.
Utilizing
bagging
method,
Gaussian
process
(GPR),
Bayesian
Ridge
Regression
(BRR),
Orthogonal
Matching
Pursuit
(OMP),
Polynomial
(PR)
were
employed
Hyper-parameter
tuning
was
achieved
gradient-based
optimization.
Results
revealed
that
emerges
most
effective
model
for
predicting
both
solubility.
For
prediction,
BAG-PR
yields
an
R2
score
0.98527,
MSE
MAE
1.4290E-03
3.40547E-02,
respectively.
Concerning
density,
achieves
outstanding
0.99766,
along
7.4759E+01
7.33964E+00,
These
results
show
learning,
polynomial
can
accurately
predict
revealing
digitoxin's
CO2.
Journal of Bio-X Research,
Journal Year:
2024,
Volume and Issue:
7
Published: Jan. 1, 2024
Targeted
gene
therapy
may
revolutionize
disease
treatment
by
precisely
treating
genetic
defects.
This
method
targets
particular
cells
or
tissues
with
therapeutic
genes
to
treat
a
variety
of
problems,
including
cancer,
hereditary
diseases,
and
viral
infections.
Viral,
nonviral,
genome
editing
techniques
such
as
CRISPR-Cas9
are
used
for
targeted
fix
modify
disease-causing
minimal
off-target
effects.
The
issues
vector
immunogenicity,
mutations,
delivery
target
persist
despite
tremendous
progress.
successful
implementation
is
further
hindered
illness
complexity
background
diversity.
These
difficulties
require
multidisciplinary
cooperation,
novel
design,
thorough
preclinical
clinical
assessments.
long-term
unforeseen
effects
must
also
be
considered
from
an
ethical
viewpoint.
has
considerable
promise,
but
more
research
technological
advances
needed
overcome
limitations
develop
safe
treatments.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 052007 - 052007
Published: Aug. 21, 2024
Melanoma
is
a
common
malignant
tumor,
with
five-year
mortality
rate
as
high
62%
in
cases
of
metastatic
melanoma
according
to
cancer
statistics
(2024).
In
recent
years,
the
focus
research
has
predominantly
centered
on
immunotherapy
and
targeted
therapy,
grappling
challenges
such
resistance
immunogenicity.
The
discovery
nanoparticles
(NPs)
brought
nano-delivery
systems
forefront
diagnosis
treatment.
Although
certain
NPs,
like
liposomes,
have
gained
clinical
approval,
utilizing
most
for
treatment
remains
largely
exploratory.
inherent
limitations
NPs
present
major
obstacle
their
translation.
By
selecting
suitable
nanocarriers
functionalizing
optimize
systems,
combining
these
other
therapies,
it
possible
reduce
systemic
toxicity
associated
conventional
therapies
themselves.
This
optimization
could
significantly
improve
effectiveness
early
detection
timely
melanoma.
However,
there
been
few
reviews
combined
application
diagnostic
past
three
years.
review
summarizes
latest
applications
over
including
innovations
achievements
both
preclinical
studies,
offering
new
perspectives
potential
future
prospects.
It
integrates
data
patent
information,
highlights
trends
system
development,
offers
insights
into
Additionally,
discusses
opportunities
treatment,
providing
foundation
advancing
diagnosis,
