Journal of Affective Disorders Reports,
Journal Year:
2021,
Volume and Issue:
6, P. 100190 - 100190
Published: July 10, 2021
Posttraumatic
stress
disorder
(PTSD)
is
a
highly
disabling
condition
associated
with
alterations
in
multiple
neurobiological
systems,
including
increases
inflammatory
and
sympathetic
function,
responsible
for
maintenance
of
symptoms.
Treatment
options
medications
psychotherapies
have
limitations.
We
previously
showed
that
transcutaneous
Vagus
Nerve
Stimulation
(tcVNS)
blocks
(interleukin
(IL)-6)
responses
to
PTSD.
The
purpose
this
study
was
assess
the
effects
tcVNS
on
PTSD
symptoms
stress.
Twenty
patients
were
randomized
double
blind
active
(N=9)
or
sham
(N=11)
stimulation
conjunction
exposure
personalized
traumatic
scripts
immediately
followed
by
measurement
IL-6
other
biomarkers
inflammation.
Patients
then
self
administered
twice
daily
three
months.
measured
Checklist
(PCL)
Clinician
Administered
Scale
(CAPS),
clinical
improvement
Clinical
Global
Index
(CGI)
anxiety
Hamilton
Anxiety
(Ham-A)
at
baseline
one-month
intervals
repeat
scripts.
After
months
treated
open
label
another
assessment
CGI.
Traumatic
increased
patients,
an
effect
blocked
(p<.05).
Active
treatment
resulted
31%
greater
reduction
compared
as
PCL
(p=0.013)
well
hyperarousal
somatic
Ham-A
p<0.05).
from
but
not
tcVNS.
Open
improvements
CGI
period
These
preliminary
results
suggest
reduces
stress,
which
may
part
underlie
beneficial
Medical Review,
Journal Year:
2022,
Volume and Issue:
2(3), P. 219 - 243
Published: June 1, 2022
Abstract
Post-traumatic
stress
disorder
(PTSD)
is
a
severe
and
heterogenous
psychiatric
that
was
first
defined
as
mental
in
1980.
Currently,
the
Diagnostic
Statistical
Manual
of
Mental
Disorders
Fifth
Edition
(DSM-5)
International
Classification
Diseases
11th
(ICD-11)
offer
most
widely
accepted
diagnostic
guidelines
for
PTSD.
In
both
categories,
experiencing
traumatic
event
(TE)
necessary
criterion
diagnosing
The
TEs
described
DSM-5
include
actual
or
threatened
death,
serious
injury,
sexual
violence,
other
extreme
stressors,
either
directly
indirectly.
More
than
70%
adults
worldwide
are
exposed
to
TE
at
least
once
their
lifetime,
approximately
10%
individuals
develop
PTSD
after
TE.
important
features
intrusion
re-experiencing
fear
memories,
pervasive
sense
threat,
active
avoidance,
hyperarousal
symptoms,
negative
alterations
cognition
mood.
Individuals
with
have
high
comorbidities
diseases,
including
major
depressive
disorder,
generalized
anxiety
substance
use
disorder.
Multiple
lines
evidence
suggest
pathophysiology
complex,
involving
abnormal
neural
circuits,
molecular
mechanisms,
genetic
mechanisms.
A
combination
psychotherapy
pharmacotherapy
used
treat
PTSD,
but
has
limited
efficacy
patients
refractory
Because
prevalence,
heavy
burden,
treatments,
requires
urgent
attention.
this
review,
we
summarize
discuss
diagnosis,
TEs,
pathophysiology,
treatments
draw
attention
its
prevention.
American Journal of Psychiatry,
Journal Year:
2023,
Volume and Issue:
180(4), P. 294 - 304
Published: April 1, 2023
Objective:
Emerging
evidence
supports
a
bidirectional
phenotypic
association
between
stress-related
disorders
and
autoimmune
disease.
However,
the
biological
underpinnings
remain
unclear.
Here,
authors
examined
whether
how
shared
genetics
contribute
to
observed
associations.
Methods:
Based
on
data
from
4,123,631
individuals
identified
Swedish
nationwide
registers,
familial
coaggregation
of
(any
disorder
or
posttraumatic
stress
[PTSD])
disease
were
initially
estimated
in
seven
cohorts
with
different
degrees
kinship.
Polygenic
risk
score
(PRS)
analyses
then
performed
individual-level
genotyping
376,871
participants
UK
Biobank
study.
Finally,
genetic
correlation
enrichment
genome-wide
study
(GWAS)
summary
statistics.
Results:
Familial
revealed
decreasing
odds
concurrence
descending
kinship
relatedness
pairs
relatives;
adjusted
ratios
1.51
(95%
CI=1.09–2.07),
1.28
CI=0.97–1.68),
1.16
CI=1.14–1.18),
1.01
CI=0.98–1.03)
for
monozygotic
twins,
dizygotic
full
siblings,
half
cousins,
respectively.
Statistically
significant
positive
associations
PRSs
disease,
as
well
disorders.
GWAS
statistics
0.26
CI=0.14–0.38)
these
two
phenotypes
10
common
genes
five
functional
modules,
including
one
module
related
G-protein–coupled
receptor
pathways.
Similar
PTSD
specific
diseases
(e.g.,
thyroid
disease)
largely
recapitulated
results
main
analyses.
Conclusions:
This
demonstrated
coaggregation,
correlation,
pathways
Frontiers in Psychology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 27, 2025
In
at-risk
societies,
the
population
of
post-traumatic
stress
disorder
(PTSD)
incidence
is
gradually
expanding
from
veterans
to
general
public.
face
high
PTSD,
exercise
therapy,
as
an
economical
and
maneuverable
treatment,
has
not
received
attention
it
deserves.
this
paper,
literature
on
PTSD
symptom
improvement
through
comb-climbing
interventions
found
that
performing
long-term
can
achieve
significant
in
symptoms
by
modulating
central
nervous
system,
autonomic
immune
system
at
physiological
level.
Aerobic
(running,
walking)
beneficial
system;
anaerobic
positively
affects
including
resistance
or
strength
endurance
training;
yoga,
which
focuses
flexibility
balance
training,
a
positive
effect
system.
Future
research
should
explore
neutral
negative
effects
mechanisms
interventions.
Expand
more
empirical
studies
special
occupational
populations.
And
implement
longitudinal
intervention
with
patients
gain
in-depth
understanding
effects.
