Recommendations for a better understanding of sex and gender in neuroscience of mental health DOI Open Access
Lara M. Wierenga, Amber Ruigrok,

Eira Ranheim Aksnes

et al.

Published: April 29, 2023

There are prominent sex/gender differences in the prevalence, expression and lifespan course of mental health neurodiverse conditions. Yet underlying sex gender related mechanisms their interactions still not fully understood. This lack knowledge has harmful consequences for those suffering from problems. Hence, we set up a co-creation session one-week workshop with multidisciplinary team 25 researchers, clinicians policy makers, to identify main barriers research neuroscience health. Based on this work, here provide recommendations methodologies, translational stakeholder involvement. These include guidelines recording, reporting, analysis beyond binary groups, open science. Improved understanding may benefit public as is an important step towards precision medicine function archetype studying diversity.

Language: Английский

Impact of Employees' Workplace Environment on Employees' Performance: A Multi-Mediation Model DOI Creative Commons

Zhenjing Gu,

Supat Chupradit,

Kuo Yen Ku

et al.

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: May 13, 2022

This study examined the impact of workplace environment on employee task performance under mediating role commitment and achievement-striving ability. For this purpose, data were collected from academic staff a cross-sectional research design, they approached through convenience sampling technique. As per recommendations established sample size criteria, we distributed sum 420 questionnaires among respondents. Among these questionnaires, only 330 received back. The returned checked for missing incomplete responses after discarding useable 314 which used analysis. Data had been analyzed structural equation modeling (SEM) by using Smart PLS 3. SEM was done based measurement models models. results indicated that positive work power to improve performance. Similarly, also improved level ability significantly. Both While in case mediation, it observed triggered further

Language: Английский

Citations

156

Neural interfaces: Bridging the brain to the world beyond healthcare DOI Creative Commons
Shumao Xu,

Yang Liu,

Hyun‐Jin Lee

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(5)

Published: March 14, 2024

Abstract Neural interfaces, emerging at the intersection of neurotechnology and urban planning, promise to transform how we interact with our surroundings communicate. By recording decoding neural signals, these interfaces facilitate direct connections between brain external devices, enabling seamless information exchange shared experiences. Nevertheless, their development is challenged by complexities in materials science, electrochemistry, algorithmic design. Electrophysiological crosstalk mismatch electrode rigidity tissue flexibility further complicate signal fidelity biocompatibility. Recent closed‐loop brain‐computer while promising for mood regulation cognitive enhancement, are limited accuracy adaptability user interfaces. This perspective outlines challenges discusses progress contrasting non‐invasive invasive approaches, explores dynamics stimulation interfacing. Emphasis placed on applications beyond healthcare, highlighting need implantable high‐resolution capabilities.

Language: Английский

Citations

22

Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies DOI Creative Commons
Anne‐Lise Goddings, David R. Roalf, Catherine Lebel

et al.

Developmental Cognitive Neuroscience, Journal Year: 2021, Volume and Issue: 51, P. 101008 - 101008

Published: Aug. 25, 2021

Diffusion magnetic resonance imaging (dMRI) provides indirect measures of white matter microstructure that can be used to make inferences about structural connectivity within the brain. Over last decade, a growing literature cross-sectional and longitudinal studies have documented relationships between dMRI indices cognitive development. In this review, we provide brief overview methods how they study review extant examining links executive functions during We explore specific functions: inhibition, working memory shifting, as well performance on complex function tasks. Concordance in findings across are highlighted, potential explanations for discrepancies results, together with challenges using child adolescent populations, discussed. Finally, future directions necessary better understand development brain functions.

Language: Английский

Citations

59

The midpoint of cortical thinning between late childhood and early adulthood differs between individuals and brain regions: Evidence from longitudinal modelling in a 12-wave neuroimaging sample DOI Creative Commons
Delia Fuhrmann, Kathrine Skak Madsen, Louise Baruël Johansen

et al.

NeuroImage, Journal Year: 2022, Volume and Issue: 261, P. 119507 - 119507

Published: July 23, 2022

Charting human brain maturation between childhood and adulthood is a fundamental prerequisite for understanding the rapid biological psychological changes during development. Two barriers have precluded quantification of maturational trajectories: demands on data estimation. Using high-temporal resolution neuroimaging up to 12-waves in HUBU cohort (N = 90, aged 7-21 years) we investigate apparent cortical thickness across adolescence. Fitting four-parameter logistic nonlinear random effects mixed model, quantified characteristic, s-shaped, trajectory thinning This approach yields biologically meaningful parameters, including midpoint (MCT), which corresponds age at cortex shows most - our sample occurring, average, 14 years age. These results show that, given suitable models, can be with precision each individual region.

Language: Английский

Citations

39

Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohort DOI Creative Commons
Madelene Holm, Esten H. Leonardsen, Dani Beck

et al.

Developmental Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 60, P. 101220 - 101220

Published: Feb. 22, 2023

The temporal characteristics of adolescent neurodevelopment are shaped by a complex interplay genetic, biological, and environmental factors. Using large longitudinal dataset children aged 9–13 from the Adolescent Brain Cognitive Development (ABCD) study we tested associations between pubertal status brain maturation. maturation was assessed using age prediction based on convolutional neural networks minimally processed T1-weighted structural MRI data. provided highly accurate reliable estimates individual age, with an overall mean absolute error 0.7 1.4 years at two timepoints respectively, intraclass correlation 0.65. Linear mixed effects (LME) models accounting for sex showed that average, one unit increase in maturational level associated 2.22 months higher across time points (β = 0.10, p < .001). Moreover, annualized change development weakly related to rate .047, 0.04). These results demonstrate link sexual early adolescence, provides basis further investigations sociobiological impacts puberty life outcomes.

Language: Английский

Citations

34

The Genesis of Schizophrenia: An Origin Story DOI
Rebecca Birnbaum, Daniel R. Weinberger

American Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 181(6), P. 482 - 492

Published: June 1, 2024

Schizophrenia is routinely referred to as a neurodevelopmental disorder, but the role of brain development in disorder typically diagnosed during early adult life enigmatic. The authors revisit model schizophrenia with genomic insights from most recent clinical genetic association studies, transcriptomic and epigenomic analyses human postmortem cellular models that recapitulate neurodevelopment. Emerging into risk continue converge on development, particularly stages may be perturbed deviate typical, normative course, resulting symptomatology. As explicate, likely dynamic context dependent, effects varying spatiotemporally, across continuum. Optimizing therapeutic strategies for heterogeneous collective individuals guided by leveraging markers derivative functional insights, well before emergence psychosis. Ultimately, rather than focus intervention adolescence or adulthood, principles prediction prophylaxis pre- perinatal neonatal best comport biology address early-stage perturbations alter trajectory.

Language: Английский

Citations

11

Puberty differentially predicts brain maturation in male and female youth: A longitudinal ABCD Study DOI Creative Commons
Dani Beck, Lia Ferschmann, Niamh MacSweeney

et al.

Developmental Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 61, P. 101261 - 101261

Published: June 1, 2023

Research has demonstrated associations between pubertal development and brain maturation. However, existing studies have been limited by small samples, cross-sectional designs, inconclusive findings regarding directionality of effects sex differences. We examined the longitudinal temporal coupling puberty status assessed using Pubertal Development Scale (PDS) magnetic resonance imaging (MRI)-based grey white matter structure. Our sample consisted 8896 children adolescents at baseline (mean age = 9.9) 6099 follow-up 11.9) from Adolescent Brain Cognitive (ABCD) Study cohort. Applying multigroup Bivariate Latent Change Score (BLCS) models, we found that PDS predicted rate change in cortical thickness among females surface area for both males females. also a correlation co-occurring changes over time males. Diffusion tensor (DTI) analyses revealed correlated fractional anisotropy (FA) females, but no significant mean diffusivity (MD). results suggest predicts maturation, strength differ sex. Further research spanning entire duration is needed to understand extent contribution on youth brain.

Language: Английский

Citations

20

Recommendations for a Better Understanding of Sex and Gender in the Neuroscience of Mental Health DOI Creative Commons
Lara M. Wierenga, Amber Ruigrok,

Eira Ranheim Aksnes

et al.

Biological Psychiatry Global Open Science, Journal Year: 2023, Volume and Issue: 4(2), P. 100283 - 100283

Published: Dec. 30, 2023

There are prominent sex/gender differences in the prevalence, expression and lifespan course of mental health neurodiverse conditions. Yet underlying sex gender related mechanisms their interactions still not fully understood. This lack knowledge has harmful consequences for those suffering from problems. Hence, we set up a co-creation session one week workshop with multidisciplinary team 25 researchers, clinicians policy makers, to identify main barriers research neuroscience health. Based on this work, here provide recommendations methodologies, translational stakeholder involvement. These include guidelines recording, reporting, analysis beyond binary groups, open science. Improved understanding may benefit public as is an important step towards precision medicine function archetype studying diversity.

Language: Английский

Citations

18

Determinants and predictors of mental health during and after COVID-19 lockdown among university students in Malaysia DOI Creative Commons
Imtiyaz Ali Mir, Shang Kuan Ng, Muhammad Noh Zulfikri Mohd Jamali

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(1), P. e0280562 - e0280562

Published: Jan. 20, 2023

Young adults, particularly university students might be at greater risk of developing psychological distress, and exhibiting symptoms anxiety depression during the COVID-19 pandemic. The primary objective this study was to explore compare determinants predictors mental health (anxiety depression) after lockdown among students.This an observational, cross-sectional with a sample size 417 students. An online survey utilizing International Physical Activity Questionnaire-Short Form (IPAQ-SF), General Anxiety Disorder-7 (GAD-7) Patient Health Questionnaire-9 (PHQ-9) distributed Universiti Tunku Abdul Rahman via Google forms.During lockdown, family income [χ2 (1, n = 124) 5.155, p 0.023], physical activity (PA) 134) 6.366, 0.012] were associated anxiety, while gender 75) 4.655, 0.031]. After both 111) 8.089, 0.004], 115) 9.305, 0.002]. During (OR 1.60, 0.018), PA 0.59, 0.011) for 0.65, 0.046) predictor depression. 1.67, 0.011), 1.70, 0.009).Significant negative effects attributed certain factors predisposed worsening status in Low income, PA, female major linked

Language: Английский

Citations

17

Influence of workplace flexibility on employee engagement among young generation DOI Creative Commons
Shi Hao Lee, Chin Wei Chong, Adedapo Oluwaseyi Ojo

et al.

Cogent Business & Management, Journal Year: 2024, Volume and Issue: 11(1)

Published: Feb. 5, 2024

Workplace flexibility has become increasingly popular and important within the landscape of human resource management especially during even after COVID19-pandemic among young working adults. The objective this study is to identify influence four forms workplace on employee engagement. used online questionnaire were answered by 185 adults below 30 years old as 2022 through Google Form. data analyzed using partial least square (PLS) structural equation modelling (SEM) technique. found that workspace operational have significant positive relationships with This provides practical direct implications for business society. Besides that, research also adds values understanding engagement scholars.

Language: Английский

Citations

7