Ketogenic diet and microRNAs: focus on cognitive function

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 17, 2025

Cognition is a mental process of understanding and learning driven by memory. Recent advances in molecular biology neuroscience have revealed fascinating interplay between cognitive function microRNAs (miRNAs). The ketogenic diet (KD) low-carbohydrate, high-fat, adequate-protein that triggers the synthesis ketone bodies, establishing ketosis. accumulating studies on human animal models shown KD benefits neurodegenerative diseases, where cognition affected. can also modulate miRNAs, molecules are dysregulated brains individuals with Alzheimer’s disease, lost. In this mini-review, we provide an overview miRNAs neurodevelopment cognition. We explore how enhance highlight protective role neurological conditions.

Language: Английский

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Dietary strategies for cardiovascular disease risk factors prevention

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(9), P. 102746 - 102746

Published: July 11, 2024

Nutrition can play a key role in cardiovascular disease risk reduction, and its factors modification. This paper aims to present, compare, summarize the main dietary concepts for preventing - obesity, hypertension, dyslipidemia. The models macronutrient intakes were compared between prevention recommendations. Dietary recommendations related selected share points, that be suggested as crucial overall reduction. Recommendations suggest limiting saturated fatty acids intake <10% of total caloric <7 % hypercholesterolemia, along with an increased mono- polyunsaturated acids. In addition, daily fiber should reach level 25-40 g. vegetables fruits consumed at minimum 200g (or 4-5 portions) each. Salt not exceed 5g/day. Alcohol generally avoided, moderate levels (sex-specific) exceeded. It is also worth noting, proteins are essential tissue formation regeneration. Carbohydrates source energy, but it necessary choose products low glycemic index. antioxidants help combat free radicals prevent cell damage.

Language: Английский

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The Potential Effects of the Ketogenic Diet in the Prevention and Co-Treatment of Stress, Anxiety, Depression, Schizophrenia, and Bipolar Disorder: From the Basic Research to the Clinical Practice

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1546 - 1546

Published: May 21, 2024

Background: The ketogenic diet (KD) has been highly developed in the past for treatment of epileptic pathological states children and adults. Recently, current re-emergence its popularity mainly focuses on therapy cardiometabolic diseases. KD can also have anti-inflammatory neuroprotective activities which may be applied to prevention and/or co-treatment a diverse range psychiatric disorders. Purpose: This is comprehensive literature review that intends critically collect scrutinize pre-existing research basis clinical data potential advantageous impacts stress, anxiety, depression, schizophrenia bipolar disorder. Methods: was performed thoroughly represent existing this topic, as well find gaps international scientific community. In aspect, we carefully investigated ultimate web databases, e.g., PubMed, Scopus, Web Science, derive currently available animal human surveys by using efficient representative keywords. Results: Just recent years, an increasing amount focused investigating possible schizophrenia, Pre-existing basic with studies consistently demonstrated promising results KD, showing propensity ameliorate symptoms However, translation these findings settings presents more complex issue. majority seem moderate, usually not controlled, assessed short-term effects KD. addition, some appear characterized enormous dropout rates significant absence compliance measurement, elevated heterogeneity their methodological design. Conclusions: Although evidence seems promising, it recommended accomplish larger, long-term, randomized, double-blind, controlled trials prospective design, order conclusive whether could act preventative factor or even agent against Basic examine molecular mechanisms above

Language: Английский

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Dietary Approach in Familial Hypercholesterolemia

Cardiogenetics, Journal Year: 2025, Volume and Issue: 15(1), P. 1 - 1

Published: Jan. 1, 2025

Introduction: Familial hypercholesterolemia (FH) is a genetic disorder that remains underdiagnosed and undertreated. It characterized by high levels of low-density lipoprotein cholesterol (LDL-C), which leads to an increased cardiovascular disease risk. Pharmacotherapy FH based on high-dose statin therapy, often combined with ezetimibe proprotein convertase subtilisin/kexin 9 inhibitors. The dietary approach important supportive part management. Methods: This review aimed present the available evidence strategies in patients. analyzed aspects included macronutrients such as fat carbohydrate intake, well role fiber, nutraceuticals (omega-3, beta-glucan, phytosterols, red yeast fermented rice extract), overall models. Results Conclusions: Based data, Mediterranean diet model advised prevention, including patients FH. Regarding detailed recommendations, current state knowledge indicates saturated fatty acids intake limitation strategy. Supplementation phytosterols fiber can be also helpful

Language: Английский

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Application and Mechanism of Action of a Ketogenic Diet in Antiepileptic Therapy

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain, which seriously affects quality life patients. Although there are various drug treatments available, many epilepsy patients still experience seizures with effect drugs and develop refractory epilepsy. The ketogenic diet can treat drug-refractory regulating body's metabolism enhance improving their cognition, behavior, sleep quality. However, no unified conclusion on mechanism through plays therapeutic role This article provides review possible mechanisms how exerts protective

Language: Английский

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An Updated Review of Popular Dietary Patterns During Pregnancy and Lactation: Trends, Benefits, and Challenges

Metabolism Open, Journal Year: 2025, Volume and Issue: 25, P. 100353 - 100353

Published: Feb. 8, 2025

This review examines nutritional needs during pregnancy and lactation, focusing on the critical nutrients required for both maternal fetal health. Essential such as folic acid, vitamin D, iron, calcium, omega-3 fatty acids play a significant role in supporting development minimizing risk of complications like gestational diabetes, hypertension, preterm birth. Various dietary patterns, including Mediterranean, vegetarian/vegan, gluten-free diets, were evaluated their adequacy potential benefits. The Mediterranean diet was highlighted its protective effects against pregnancy-related health issues. In contrast, identified vegetarian vegan diets requiring careful planning to ensure sufficient intake key nutrients. Additionally, explored implications diabetes strategies managing blood sugar levels. intermittent fasting also discussed, with mixed evidence regarding safety impact outcomes. Overall, stresses importance tailored guidance optimal mother developing fetus lactation.

Language: Английский

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Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Obesity is an established risk factor for breast cancer (BC), yet the specific mechanisms driving this association remain unclear. Dysregulated lipid metabolism has emerged as a key in cell biology. While obesity often accompanied by hyperlipidemia, isolated impact of elevated levels on BC growth not been experimentally tested. Using E0771 orthotopic model obesity-accelerated immune-competent mice, we investigated direct role systemic lipids tumor growth. Combining dietary and genetic mouse models, show that circulating are sufficient to accelerate even absence or alterations blood glucose and/or insulin levels. Pharmacological lowering attenuates obese suggesting fueling expansion. Notably, also weight loss alone, without corresponding reduction such induced ketogenic diet, fails protect against BC, highlighting necessity targeting obesity-associated BC. Our findings establish hyperlipidemia critical driver progression suggest lipid-lowering interventions may be promising strategy mitigate individuals.

Language: Английский

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The Role of Dietary Education in Cardiac Rehabilitation

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1082 - 1082

Published: March 19, 2025

Cardiovascular disease remains a leading cause of death globally; however, most cases could be prevented by addressing modifiable risk factors, such as unhealthy lifestyle including diet. These aspects are also crucial in secondary prevention. Cardiac rehabilitation programs vital improving cardiovascular outcomes, and apart from recommended pharmacotherapy, they focus on modifications, exercise, healthy diet, smoking cessation. The aim this review was to summarize the evidence role dietary education cardiac programs. available data show that nutritional recommendations play an important programs, with Mediterranean diet being widely for its benefits. Adherence course has been linked improved metabolic outcomes; further studies long-term follow-up needed. Moreover, while challenges following exist, individualized care support essential successful outcomes Including is part after myocardial infarction; more needed investigate personalized rehabilitation.

Language: Английский

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Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence

Published: July 11, 2024

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized by the development and progression of multiple renal cysts, leading to progressive function decline. To date, only approved treatment for this condition able slow down loss annual function, without stopping disease progression. Furthermore, therapy patients with rapid its compliance problematic because impact drug on quality life. The recent literature suggests that cystic cells are subject metabolic dysregulation in glucose pathway (Warburg Effect). This finding paved way new lines research targeting potential therapeutic interventions ADPKD. In particular, review highlights latest studies use ketosis, through ketogenic dietary (daily calorie restriction, intermittent fasting, time-restricted feeding, diets), as strategy ADPKD, possible involvement microbiota interventions&rsquo; effect.

Language: Английский

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The Long-Term Treatment of Drug-Resistant Migraine with the Modified Atkins Ketogenic Diet: A Single-Center, Retrospective Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4324 - 4324

Published: Dec. 15, 2024

Despite advances in pharmacological therapies, migraine patients are often drug resistant. Further therapeutic options this field are, therefore, desirable. Recent studies have highlighted the efficacy of ketogenic diet (KD) on improving migraine, but data their long-term and safety lacking. In study, we retrospectively evaluated effectiveness modified Atkins (MAD) episodic or chronic drug-resistant patients. 52 diagnosed with under were evaluated. total, 41 followed for 6 months 33 12 months. After both months, frequency, length, intensity episodes, as well number medications significantly decreased respect to start diet. Body mass index, high sensitivity PCR, diastolic blood pressure, fasting plasma insulin HOMA index also reduced after No major metabolic changes observed during MAD treatment. conclusion, KD has been shown be effective safe treatment migraine. A dropout rate still remains an important factor, which limits its use.

Language: Английский

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