The cutting edge: Promising oncology radiotracers in clinical development
Diagnostic and Interventional Imaging,
Journal Year:
2024,
Volume and Issue:
105(10), P. 400 - 406
Published: May 14, 2024
Language: Английский
Oligometastatic Urothelial Cancer and Stereotactic Body Radiotherapy: A Systematic Review and an Updated Insight of Current Evidence and Future Directions
Cancers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3201 - 3201
Published: Sept. 20, 2024
Background:
Stereotactic
body
radiation
therapy
(SBRT)
is
the
most
commonly
used
metastasis-directed
(MDT)
for
oligometastatic
urothelial
carcinoma
(omUC).
Despite
efforts
in
defining
this
disease
entity,
open
questions
remain
concerning
role
of
MDT
and
use
biomarkers,
imaging,
its
combination
with
systemic
therapies.
The
aim
present
systematic
review
to
provide
an
updated
overview
current
clinical
evidence
on
SBRT
omUC
terms
survival
local
control
benefits.
We
also
updates
controversial
areas
future
directions
emerging
field.
Methods:
With
a
approach,
following
PRISMA
recommendations,
we
searched
two
databases
identify
select
articles
published
up
until
March
2024
reporting
or
without
concomitant
Prospective
randomized
non-randomized
studies
as
well
retrospective
were
included.
Results:
Eight
selected
data
extraction
293
patients
treated
collectively
analyzed.
In
metachronous
patients,
delivered
ablative
doses
(BED10
≥
78
Gy)
was
associated
2-year
overall
(OS)
rate
50.7%
(95%
CI
35.1–64.4%).
sub-ablative
=
43.2
immunotherapy
did
not
demonstrate
significant
outcome
improvement
prospective
studies.
tolerance
good,
only
one
study
toxicity
grade
3
18%
immunotherapy.
Conclusions:
effective
widely
available
option
omUC,
although
based
limited
number
attempt
immune
response
trigger
immunotherapy,
no
outcomes
has
been
observed.
integration
new
agents
will
likely
define
scenario
treatment
omUC.
protocol
registered
PROSPERO,
ID:
CRD42024522381.
Language: Английский
A tumor-like renal arteriovenous malformation on 18F-PSMA-1007 PET/CT: a case report
Yaqi Feng,
No information about this author
Wenjiang Zhao,
No information about this author
Yawen Feng
No information about this author
et al.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: May 31, 2024
Background
Renal
arteriovenous
malformations
(rAVMs)
are
congenital
abnormal
pathways
between
renal
arteries
and
veins
that
rare
in
the
general
population.
It
is
often
misdiagnosed
as
malignant
tumors
with
abundant
blood
supply,
definitive
diagnosis
primarily
relies
on
angiography.
Multimodality
imaging,
including
contrast-enhanced
computed
tomography
(CT),
magnetic
resonance
imaging
(MRI),
positron
emission
(PET)/CT
plays
an
important
role
differential
of
space-occupying
lesions.
Case
presentation
A
56-year-old
man
presented
abdominal
distension,
loss
appetite,
back
pain
without
obvious
cause
2
years
ago,
nausea
vomiting,
or
frequent
urination.
Gastroscopy
colonoscopy
showed
multiple
polyps
duodenum
colon.
Abdomen
CT
revealed
a
mass
1.6
×
1.4
cm
left
kidney,
which
was
considered
to
be
tumor.
PET/CT
performed
for
further
diagnosis;
18
F-fluorodesoxyglucose
(
F-FDG)
scan
mild
uptake
mass,
while
no
F-
prostate-specific
membrane
antigen
(PSMA)
observed.
Following
multidisciplinary
discussion,
possibility
AVMs
subsequently
confirmed
by
angiography
diagnosis.
Then,
selective
segmental
artery
embolization
treatment.
Conclusion
extremely
clinical
practice.
Due
limited
research
application
F-FDG
F-PSMA
AVMs,
its
remains
largely
unexplored.
With
increasing
popularity
comprehensive
disease
has
become
indispensable.
We
report
first
case
PSMA
when
expression
absent
should
considered.
Language: Английский