Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(11)
Published: Nov. 1, 2023
Language: Английский
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 12, 2024
Abstract Psoriasis is an immune-mediated inflammatory skin disease, involving a complex interplay between genetic and environmental factors. Previous studies have demonstrated that factors play major role in the pathogenesis of psoriasis. However, non-genetic are also necessary to trigger onset recurrence psoriasis genetically predisposed individuals, which include infections, microbiota dysbiosis gut, dysregulated lipid metabolism, sex hormones, mental illness. can be induced by other triggers, such as trauma, unhealthy lifestyles, medications. Understanding how these triggers provides insights into pathogenesis, well better clinical administration. In this review, we summarize for update current evidence on underlying mechanism elicit disease.
Language: Английский
Citations
32
British Journal of Dermatology, Journal Year: 2024, Volume and Issue: 191(3), P. 405 - 418
Published: May 14, 2024
Abstract Background Psoriasis is a T cell-mediated chronic inflammatory skin condition characterized by the interaction of cells with various cell types, forming an microenvironment that sustains psoriatic inflammation. Homeostasis these tissue-resident supported fibroblasts, primary structural in dermis. In psoriasis, there increased expression matrix metalloproteinase 2 (MMP2), mediating alterations tissues and modulating Additionally, CD100–plexin-B2 (PLXNB2) axis known to enhance psoriasis inflammation via keratinocytes, CD103 levels are associated severity upon relapse. Objectives To elucidate role fibroblasts MMP2–CD100 Methods CD100 function were assessed using immunofluorescence, enzyme-linked immunosorbent assay, single-cell transcriptome sequencing, cellular analyses quantitative reverse transcriptase polymerase chain reaction. CD8+ from people isolated magnetic beads, investigate regulatory effect MMP2 on their membranes. Single-cell spatial mimetic timing analysis, immunofluorescence flow cytometry used determine origin its impact CD103+ cells. The hypotheses further validated vivo inhibitors. Results Soluble (sCD100) was significantly upregulated both lesions peripheral blood, amplifying promoting production cytokines endothelial sCD100–PLXNB2 axis. Fibroblasts highly expressed (MMP2hi) exacerbated symptoms facilitating shedding T-cell it shown upregulation residency factor co-cultures Inhibitors targeting effective reducing imiquimod-induced model. Conclusions Our findings underscore pivotal MMP2hi amplification recurrence responses psoriasis. These augment through CD100–PLXNB2 membranes upregulating CD103, thereby enhancing residency.
Language: Английский
Citations
5
The Journal of Dermatology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Abstract Alopecia areata (AA) is a chronic, autoimmune skin disease characterized by non‐scarring hair loss. Baricitinib, Janus kinase inhibitor (JAKi), prevents loss and promotes regrowth inhibiting the inflammatory kinase‐signal transducer activator of transcription (JAK–STAT) signaling pathway involved in cytotoxic T cell responses targeting follicles. The introduction JAKi has transformed treatment against severe AA. However, to are highly variable among patients, predictors responsiveness remain insufficiently elucidated. This study aimed identify independent predictive factors for efficacy baricitinib patients with AA using multivariate analyses. A retrospective was conducted on 70 who started at Tohoku University Hospital between July 2022 August 2023. primary outcome percentage achieving Severity Tool (SALT) score ≤20 after 9 months treatment. Multivariate analysis assessed potential responses, including type, sex, age, duration, history atopic dermatitis, intravenous methylprednisolone pulse (IVMP) therapy, Clinician‐Reported Outcome (ClinRO) measures eyebrows eyelashes. Achievement SALT improvement rates were used as objective variables Among completing treatment, 41% achieved ≤20. analyses identified several positive outcomes, shorter duration (≤4 years), IVMP, therapy ≤95 initiation, female sex. Further, we found differential response patterns based type Specifically, significantly influenced ophiasis alopecia (OA) associated poorest rate. In summary, pre‐treatment score.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 441 - 441
Published: March 19, 2025
Type 1 diabetes (T1D) is an organ-specific autoimmune disease that results in the selective loss of pancreatic beta cells and eventual deficit insulin production to maintain glucose homeostasis. It now increasingly accepted this dynamic process multifactorial; involves a variety immune which contribute inflamed microenvironment; condition heterogenous, resulting variable rates subsequent cell damage. In review, we will explore current understanding cellular interactions between both resident infiltrating within environment, highlighting key mechanisms may promote destruction islet damage associated with T1D.
Language: Английский
Citations
0
Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(5), P. 258 - 271
Published: April 10, 2024
Language: Английский
Citations
3
Lara D. Veeken, Journal Year: 2024, Volume and Issue: 64(1), P. 56 - 64
Published: Aug. 16, 2024
Psoriatic arthritis (PsA) is a chronic rheumatic disease that usually appears in patients with skin psoriasis, making it model for detection of joint the pre-clinical phases setting where therapy cutaneous may ameliorate or prevent development. Such PsA prevention credible due to increasingly recognized closely shared immunopathology between and joints, especially entheses. Recently, several initiatives have explored concept PsA, nomenclatures been developed recent EULAR nomenclature proposing simplified three stages from psoriasis clinical development, namely at risk subclinical early PsA. A better comprehension identification individuals predisposed its development could enable interventions 'prevent' appearance Several retrospective observational studies demonstrated interception feasibility, i.e. treatment people particular using biologic disease-modifying drugs. However, further data are urgently required unexpected findings some TNF inhibition does not reduce rate In this review we address current challenges including comparisons pre-PsA sets, factors potential interception.
Language: Английский
Citations
2
Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1342 - 1342
Published: June 17, 2024
Gastrointestinal cancers, which include a variety of esophageal and colorectal malignancies, present global health challenge require effective treatment strategies. In the evolving field cancer immunotherapy, tissue-resident memory T cells (Trm cells) have emerged as important players in immune response within nonlymphoid tissues. this review, we summarize characteristics functions Trm discuss their profound implications for patient outcomes gastrointestinal cancers. Positioned strategically peripheral tissues, beyond surveillance, affecting tumor progression, prognosis, to immunotherapy. Studies indicate that are prognostic markers correlate positively with enhanced survival. Their presence microenvironment has sparked interest therapeutic potential, particularly respect checkpoint inhibitors, may improve treatment. Understanding how work will not only help prevent spread through but also contribute disease prevention at early stages well vaccine development. The role goes just cancer, they potential applications infectious autoimmune diseases. This review provides thorough analysis lead personalized therapies.
Language: Английский
Citations
1
Dermatology and Therapy, Journal Year: 2024, Volume and Issue: 14(9), P. 2607 - 2620
Published: July 29, 2024
Knowing the remission duration after biologics discontinuation in patients with psoriasis is important, especially when disease relapse defined as restart of systemic agents, because it also reflects real-world clinical practice topical treatment alone not adequate for control, and a treatment, including biologic, needed. Biologics are currently indicated who candidates treatments. We included 42 were followed up regularly end risankizumab, guselkumab mirikizumab trials investigated drug-free (DFR). A Kaplan–Meier survival analysis Cox regression model employed to identify possible risk factors relapse. Overall, 38/42 (90.5%) experienced relapses discontinuing trial during follow-up period at least 96 weeks 227 weeks. In all relapse, median DFR was 104 days. revealed significant 1-year (DFS) difference between risankizumab (Z) (T) + (M) (p = 0.0462). DFS curves noted categorized by > or ≤ 2 years 0.1577) maintenance area severity index score (PASI) 90 0.1177). Univariate identified that age [hazard ratio (HR) 1.030 (1.000–1.060), p 0.0467] [HR 1.046(1.009–1.084), 0.0134] significantly associated risk. established on basis multivariable results. Risk value 0.021038 * Age 0.515628 Biologic_type (Z 0,T/M 1) 0.025048 Disease_Duration. The validated divided into two groups (1.5). high-risk group (risk 1.5) had non-significant higher than low-risk < 1.5), hazard 1.62 [95% confidence interval (CI) 0.82–3.23, 0.1809]. Types used, years, PASI improvement affect discontinuation. Further studies consisting larger patient number longer needed verify our findings. ClinicalTrials.gov identifiers NCT02694523, NCT03047395, NCT02207224, NCT02576431, NCT03482011, NCT03556202.
Language: Английский
Citations
1
The Indonesian Biomedical Journal, Journal Year: 2024, Volume and Issue: 16(4), P. 353 - 62
Published: Aug. 28, 2024
BACKGROUND: Probiotics may modify the gut microbiome and have been proven to improve psoriasis vulgaris. Lactiplantibacillus plantarum IS-10506 is a probiotic strain of Indonesian origin. It offers safe effective for patients in Indonesia. This study was conducted evaluate effect L. on clinical immunology markers vulgaris.METHODS: randomized, placebo-controlled, double-blind trial compared (2×1010 CFU/day) placebo 49 mild-moderate vulgaris, which were divided into intervention (n=24) control groups (n=25). The interventions given twice daily 12 weeks. Both received topical corticosteroid emollient as standard treatment. Psoriasis area severity index (PASI), dermatology life quality (DLQI), interleukin (IL)-10, IL-17, forkhead box protein (Foxp3) then assessed.RESULTS: Mean PASI score subjects group significantly reduced at week-6 (p=0.024), sustained until week-12 (p=0.049). At week-12, DLQI scores lower than (7.57±5.77 vs. 7.79±5.48). IL-17 level decreased (p=0.013), while IL-10 Foxp3 increased (p≤0.001 p=0.048, respectively) group. Six months after completion study, had probability flares (52.2%) (79.2%). Two receiving probiotics one noticed changes defecation frequency, another subject complained mild nausea.CONCLUSION: might effectively outcomes immune biomarkers vulgaris patients, potentially acting an adjuvant therapy.KEYWORDS: psoriasis, probiotic, severity, marker, human health
Language: Английский
Citations
1