Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 2485 - 2529

Published: June 1, 2024

Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,

Language: Английский

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Ferroptosis and cuproptosis: Metal-dependent cell death pathways activated in response to classical chemotherapy – Significance for cancer treatment?

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(4), P. 189124 - 189124

Published: May 25, 2024

Apoptosis has traditionally been regarded as the desired cell death pathway activated by chemotherapeutic drugs due to its controlled and non-inflammatory nature. However, recent discoveries of alternative pathways have paved way for immune-stimulatory treatment approaches in cancer. Ferroptosis (dependent on iron) cuproptosis copper) hold promise selective cancer targeting overcoming drug resistance. Copper ionophores iron-bearing nano-drugs show potential clinical therapy single agents adjuvant treatments. Here we review up-to-date evidence involvement metal ion-dependent cytotoxicity classical (alkylating agents, topoisomerase inhibitors, antimetabolites, mitotic spindle inhibitors) their combinations with ferroptosis inducers, indicating prospects, advantages, obstacles use.

Language: Английский

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Targeting Ferroptosis as an Advance Strategy in Cancer Therapy

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 41(10-12), P. 616 - 636

Published: July 3, 2024

This study innovates by systematically integrating the molecular mechanisms of iron death and its application in cancer therapy. By deeply analyzing interaction between tumor microenvironment, provides a new theoretical basis for treatment directions developing more effective strategies. In addition, points to critical issues barriers that need be addressed future research, providing valuable insights into use clinical translation.

Language: Английский

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Epithelial-mesenchymal Transition Promotes Metabolic Reprogramming to Suppress Ferroptosis

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Ferroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 22, 2024

The identification of ferroptosis represents a pivotal advancement in the field cell death research, revealing an entirely novel mechanism cellular demise and offering new insights into initiation, progression, therapeutic management various diseases. Ferroptosis is predominantly induced by intracellular iron accumulation, lipid peroxidation, or impairments antioxidant defense system, culminating membrane rupture consequent death. Studies have associated with wide range diseases, enhancing our comprehension its underlying mechanisms, we can formulate innovative strategies, thereby providing renewed hope for patients.

Language: Английский

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Environmental Determinants of Ferroptosis in Cancer

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3861 - 3861

Published: July 29, 2023

Given the enormous suffering and death associated with human cancers, there is an urgent need for novel therapeutic approaches to target tumor growth metastasis. While initial efforts have focused on dysregulated oncogenic program of cancer cells, recent focus has been modulation targeting many “cancer-friendly,” non-genetic microenvironmental factors, which support enable progression Two prominent examples are anti-angiogenesis immunotherapy that tumor-supporting vascularization immune-suppressive microenvironment (TME), respectively. Lately, significant interest in potential ferroptosis, a natural suppression mechanism normally occurs as result oxidative stress, iron imbalance, accumulation lipid peroxides. numerous studies identified various cell intrinsic mechanisms protect or promote role TME stress factors also recently recognized modulate cells’ susceptibility ferroptosis. This review aims compile highlight evidence these how stresses affect their implications stages development expected response ferroptosis-triggering therapeutics under development. Consequently, understanding ways enhance ferroptosis sensitivity both intracellularly may optimize minimize prevent

Language: Английский

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Mechanisms of Cancer Cell Radioresistance: Modern Trends and Research Prospects

BIOPHYSICS, Journal Year: 2024, Volume and Issue: 69(6), P. 1064 - 1088

Published: Dec. 1, 2024

Language: Английский

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