Immunological Investigations,
Journal Year:
2023,
Volume and Issue:
53(1), P. 40 - 69
Published: Nov. 21, 2023
The
remarkable
diversity
of
lymphocytes,
essential
components
the
immune
system,
serves
as
an
ingenious
mechanism
for
maximizing
efficient
utilization
limited
host
defense
resources.
While
cell
adhesion
molecules,
notably
in
gut-tropic
T
cells,
play
a
central
role
this
mechanism,
counterbalancing
molecular
details
have
remained
elusive.
Conversely,
we've
uncovered
pathways
enabling
extracellular
vesicles
secreted
by
lymphocytes
to
reach
gut's
mucosal
tissues,
facilitating
immunological
regulation.
This
discovery
sheds
light
on
fine-tuning,
offering
insights
into
regulation
mechanisms.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(8), P. 2307 - 2307
Published: April 14, 2023
In
addition
to
intrinsic
genomic
and
nongenomic
alterations,
tumor
progression
is
also
dependent
on
the
microenvironment
(TME,
mainly
composed
of
extracellular
matrix
(ECM),
secreted
factors,
bystander
immune
stromal
cells).
chronic
lymphocytic
leukemia
(CLL),
B
cells
have
a
defect
in
cell
death;
contact
with
TME
secondary
lymphoid
organs
dramatically
increases
cells'
survival
via
activation
various
molecular
pathways,
including
receptor
CD40
signaling.
Conversely,
CLL
increase
permissiveness
by
inducing
changes
ECM,
cells.
Recently,
vesicles
(EVs)
released
into
emerged
as
key
arbiters
cross-talk
The
EVs'
cargo
can
contain
bioactive
substances
(including
metabolites,
proteins,
RNA,
DNA);
upon
delivery
target
cells,
these
induce
intracellular
signaling
drive
progression.
Here,
we
review
recent
research
biology
EVs
CLL.
diagnostic/prognostic
significance
clearly
influence
clinical
outcome
CLL;
hence,
from
perspective
blocking
CLL-TME
interactions,
are
therapeutic
targets.
identification
novel
EV
inhibitors
might
pave
way
development
combination
treatments
for
optimization
currently
available
immunotherapy).
Seminars in Cancer Biology,
Journal Year:
2023,
Volume and Issue:
96, P. 36 - 47
Published: Sept. 23, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
type
of
cancer
alarmingly
expanding
in
our
modern
societies
that
still
proving
to
be
very
challenging
counteract.
This
disease
constitutes
quintessential
example
the
multiple
interactions
existing
between
tumour
and
its
surrounding
microenvironment.
In
particular,
PDAC
characterized
by
immunosuppressive
environment
favours
growth
makes
this
resistant
immunotherapy.
The
primary
releases
many
factors
influence
both
microenvironment
immune
landscape.
Extracellular
vesicles
(EVs),
recently
identified
as
indispensable
entities
ensuring
cell-to-cell
communication
physiological
pathological
processes,
seem
play
pivotal
function
delivery
these
tumour-surrounding
tissues.
review,
we
summarize
present
understanding
on
crosstalk
among
cells
cellular
emphasizing
pro-malignant
role
played
extracellular
vesicles.
We
also
discuss
how
greater
knowledge
roles
EVs
escape
could
translated
into
clinical
applications.
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
Journal Year:
2024,
Volume and Issue:
33(1), P. 133 - 148
Published: Sept. 13, 2024
Lung
cancer
is
a
life-threatening
disease
that
occurs
worldwide,
but
especially
common
in
China.
The
crucial
role
of
the
tumour
microenvironment
(TME)
non-small
cell
lung
(NSCLC)
has
attracted
recent
attention.
Cancer-associated
fibroblasts
(CAFs)
are
main
factors
contribute
to
TME
function,
and
CAF
exosomes
closely
linked
NSCLC.
expression
levels
miR-3124-5p
Toll-interacting
protein
(TOLLIP)
were
analysed
by
bioinformatics
prediction
combined
with
RT-qPCR/Western
Blot
detection.
Fibroblasts
isolated
identified
from
clinical
NSCLC
tissues.
Transmission
electron
microscopy
Western
used
identify
these
cells.
Changes
proliferation
(CCK-8
clone
formation),
migration
(wound
healing),
invasion
(transwell)
cells
measured.
Luciferase
reporter
test
was
applied
clarify
binding
TOLLIP.
TOLLIP/TLR4/MyD88/NF-κB
pathway
proteins
determined
using
blot
analysis.
MiR-3124-5p
overexpressed
tissues
dramatically
enriched
CAF-derived
exosomes.
Cellular
experiments
revealed
CAFs
delivered
into
via
exosomes,
stimulating
progression.
acted
as
sponge
negatively
regulate
TOLLIP
expression,
which
activated
TLR4/MyD88/NF-κB
axis
promote
occurrence
development
Functional
salvage
tests
performed
determine
whether
CAF-exosome-derived
plays
pro-cancer
affecting
signalling
pathway.
These
results
provide
an
interesting
direction
for
diagnosis
therapy
Immunological Investigations,
Journal Year:
2023,
Volume and Issue:
53(1), P. 40 - 69
Published: Nov. 21, 2023
The
remarkable
diversity
of
lymphocytes,
essential
components
the
immune
system,
serves
as
an
ingenious
mechanism
for
maximizing
efficient
utilization
limited
host
defense
resources.
While
cell
adhesion
molecules,
notably
in
gut-tropic
T
cells,
play
a
central
role
this
mechanism,
counterbalancing
molecular
details
have
remained
elusive.
Conversely,
we've
uncovered
pathways
enabling
extracellular
vesicles
secreted
by
lymphocytes
to
reach
gut's
mucosal
tissues,
facilitating
immunological
regulation.
This
discovery
sheds
light
on
fine-tuning,
offering
insights
into
regulation
mechanisms.
