The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 131(6), P. 957 - 969

Published: June 27, 2024

We proposed the Physical Activity and Cancer Control (PACC) framework in 2007 to help organise, focus, stimulate research on physical activity eight cancer control categories: prevention, detection, treatment preparation/coping, coping/effectiveness, recovery/rehabilitation, disease prevention/health promotion, palliation, survival. This perspective paper provides a high-level overview of scientific advances across categories, summarises current guidelines, updates PACC framework, identifies remaining emerging knowledge gaps, future directions. Many have been made that are reflected updated guidelines for six categories apart from detection palliation. Nevertheless, minimal optimal type, dose, timing remain unknown, especially understudied population subgroups defined by age, race/ethnicity, resource level regions/countries. To achieve full benefit control, should use innovative study designs include diverse at-risk populations sites. Additionally, effective behaviour change strategies needed increase levels implementation science accelerate translation evidence generation into practical, real-world interventions.

Language: Английский

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The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

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Strategies to improve participation in exercise programmes during chemotherapy: a modified nominal group technique

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Exercise can help people manage many of the side effects chemotherapy treatment. Clear guidelines exist outlining benefits exercise during and recommended dosage; however, achieving these remains problematic. The purpose this study is to reach an agreement on suitable strategies improve recruitment, adherence, retention rates programmes with involvement key stakeholders. This used a modified nominal group technique (NGT). Participants included individuals lived experience healthcare professionals working in oncology. Three workshops were carried out, two in-person one online. addressed first four stages NGT, introduction, idea generation, round-robin recording, discussion. Voting ranking ideas occurred online workshop. Nineteen took part study, including 12 seven professionals. highest-ranked strategy recruitment was inform about at time receiving their treatment plan, 53% preference votes. also agreed that direct instruction from oncologist would have greatest impact successful programme, 47% To enhance programme delivered facility received 46% Finally, 43% participants provision pedometer support retention, 86% wanted receive weekly phone calls/check-ins. provides overcome barriers chemotherapy, will optimise participant engagement for future interventions. stakeholders contribute towards ensuring interventions are pragmatic patient-centred.

Language: Английский

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Patient experiences of participating in a cancer rehabilitation triage and referral system in the Irish healthcare system

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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An integrated framework for the study of exercise across the postdiagnosis cancer continuum

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 23, 2024

Exercise plays many important roles across the entire cancer continuum that have been described in previous frameworks. These frameworks, however, generally provided a simplified description of exercise postdiagnosis. The modern treatment landscape has become complex and often consists multiple lines multimodal treatments combined concurrently and/or sequentially delivered over months or years. This complexity requires more multifaceted targeted approach to study after diagnosis. Here, we propose new integrated framework—Exercise Across Postdiagnosis Cancer Continuum (EPiCC)—that highlights distinct for disease supportive care from diagnosis until death. We also terminology clarify emerge context landscape. EPiCC Framework is structured around sequential highlight six treatment-related time periods exercise—before treatments, during between immediately successful longer term survivorship end life unsuccessful treatments. proposes specific as intervention will vary depending on its positioning within different combinations. As treatment, may serve “priming therapy”, primary therapy, neoadjuvant induction “bridging adjuvant consolidation maintenance salvage therapy. intervention, prehabilitation, intrahabilitation, interhabilitation, rehabilitation, “perihabilitation”, health promotion/disease prevention, palliation. To date, studied all but only relation some Moreover, fewer studies examined any combination. Future research needed contained aim stimulate targeted, integrated, clinically-informed

Language: Английский

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Retention rates and reasons for non-retention in exercise oncology trials in the post-treatment phase—a systematic review

Journal of Cancer Survivorship, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Abstract Purpose Retention is a key marker of trial success. Poor retention can induce bias, reduce statistical power and minimise the validity trials. This review examined rates in exercise trials cancer survivors, reasons for non-retention strategies utilised. Methods A systematic was conducted using predefined search strategy EMBASE RCTs, MEDLINE OVID, CINAHL, Web Science—Core Collection Cochrane Central Register Controlled Trials (CENTRAL). The on 27/03/2023. Title abstract screening, full text data extraction were completed duplicate. Results Of 17,524 studies identified, 67 involving 6093 participants included. median overall rate immediately post-intervention 89.85%, range (52.94–100%) mean 87.36% (standard deviation 9.89%). colorectal survivors only had highest (94.61%), followed by breast (92.74%), prostate (86.00%) haematological cancers (85.49%). Studies mixed cohorts lowest (80.18%). most common wait-list control groups, regular check-ins/reminders free equipment. Common lost to follow-up, health problems, personal including family/work commitments travel burden, disease progression. Conclusions oncology are approximately 90% post-interventions. Our previous work highlighted variable suboptimal recruitment 38% (range 0.52–100%). Recruitment rather than should be prioritised methodology research oncology. Implications Optimising quality critical informing high survivorship care. PROSPERO registration number: CRD42023421359.

Language: Английский

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Personalised exercise rehabilitation in cancer survivorship: Findings from a triage and referral feasibility study

Journal of Cancer Survivorship, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Language: Английский

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Analysis of Factors Related to Physical Activity Levels Among Lung Cancer Survivors Who Underwent Nonsurgical Treatment: A Cross‐Sectional Study

Journal of Clinical Nursing, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

ABSTRACT Aim(s) The study aimed to investigate the current status of physical activity (PA) levels and associated factors among lung cancer survivors who have undergone nonsurgical treatments. Background PA has been incorporated as a nonpharmacological intervention in rehabilitation programmes patients, playing crucial role alleviating symptom burden enhancing quality life survivors. Understanding potential influencing aids formulating targeted strategies. Design A multicentre cross‐sectional study. Methods Convenience sampling was utilised survey from respiratory oncology departments 12 hospitals across Eastern, Central Western China, spanning June 2023 January 2024. Social demographic characteristics, disease‐related features, health behaviour abilities, psychological were collected through combination clinical case systems used record patients' treatment medical conditions self‐reported questionnaires. Additionally, measurements grip strength 6‐min walk test conducted for patients. Descriptive analysis, bivariate analysis multivariate logistic regression conducted. Results Only 109 patients (16.2%) achieved high levels. Multivariate indicated differences age, residential location, employment status, religion, stage, strength, albumin concentration, blood urea, Anderson symptom, depression capacity with varying Conclusions Significant associations observed between age ≥ 75 years, residing urban areas, unemployment, absence religious beliefs, Stage IV cancer, lower higher scores, scores These should be considered when developing plans. Relevance Clinical Practice This offers insights subsequent programmes. In practice, healthcare professionals continuously educate about benefits exercise help them incorporate into their daily lives. emphasising multidisciplinary collaboration involving therapists, nutritionists mental experts is ensuring safe effective PA, thereby improving life. Reporting Method Our complies Strengthening Observational Studies Epidemiology (STROBE) Checklist: studies. Patient or Public Contribution At phase collecting data, participants recruited fill Trial Registration Chinese Registry: ChiCTR2300072609

Language: Английский

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Personalised Exercise Rehabilitation in Cancer Survivorship: Findings from a Triage and Referral Implementation study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 20, 2024

Purpose: Screening, triage and referral systems are proposed as efficient, needs-based models of cancer rehabilitation. This study aimed to evaluate the feasibility real-world application PERCS Triage Referral system. Methods: Utilising a pre-post design, reach, effectiveness, implementation was evaluated quantitatively in context physiotherapy-led clinic for patients diagnosed with during COVID-19. Assessments at baseline 12-weeks (T1) included medical, social physical activity history, patient-reported outcomes, performance-based measures. Following assessment, system allocated participants one three exercise pathways. Results: Sixty-four were recruited over 5 months (25.2% recruitment rate; female n=39; mean age 61.4 (12.4) years). Almost all (90.6%) required support become more physically active. The majority (n=43, 66%) referred community programmes n=15 (23%) physiotherapy Five medical pre-clearance re-triaged 1-week. Mean cost per participant services €107.70. At T1, adherence guidelines increased aerobic (44% 83%) resistance (13% 67%) exercise. Improvements observed hand grip strength (x̄ 2.59kg, p=0.001), 30 second sit-to-stand (x̄+3.7stands, p<0.001) 6-minute walk test +37.3m, p=0.001). Conclusion: PERCS appropriately triaged right level rehabilitation individual needs effectively implemented. Participants experienced improvements functioning metrics. Implications Cancer Survivors: Triage can effective patient-centred into care. ClinicalTrials.gov registration: NCT05615285

Language: Английский

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