A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto’s Thyroiditis: Analysis of Asthenia as Admission Complaint DOI Creative Commons

Ana Valea,

Mihai Costăchescu,

Mihaela Stanciu

et al.

Life, Journal Year: 2024, Volume and Issue: 14(11), P. 1380 - 1380

Published: Oct. 27, 2024

Background: Amid the large panel of autoimmune thyroid diseases, Hashimoto’s thyroiditis (HT) represents a major point across multidisciplinary daily practice. When it comes to clinical picture, particularly in regard asthenia (also described as “fatigue” or “decreased energy”), differential diagnosis is challenging, and meticulous anamnesis should be backed up by focused lab investigations. Our objective was analyze newly diagnosed patients with HT relationship presence an admission complaint. Methods: This retrospective, multi-centric, real-life study conducted secondary endocrine units (university hospitals) from July 2022 2023. The exclusion criteria were COVID-19 infection; active malignancy, etc. Results: cohort (N = 120) included group (AS, 49.2%) non-AS similar age (49.3 ± 14.7 vs. 47.1 14.8 y, p 0.426). Headache more frequent AS (35.6% 18%, 0.03). Thyroid function HT-related antibodies assays between groups show no correlation serum total cholesterol triglycerides, respectively. TSH levels did not vary among sub-groups (p 0.701). One third studied population affected hypothyroidism (TSH > 4.5 μIU/mL), being seen at higher rate (39%) (23%). Total positively correlated patients’ (r 0.180, 0.049) triglycerides 120; r 0.324, < 0.001), found only 0.246, 0.006, respectively, 0.319, 0.001). Conclusions: analysis pinpointed fact that, practice, complaint seems less indicator underlying dysfunction level against without full picture thyrotoxicosis myxoedema.

Language: Английский

Metal‐Organic Frameworks (MOFs): Classification, Synthesis, Modification, and Biomedical Applications DOI
Dayang Wang,

Huanchen Yao,

Jiashuo Ye

et al.

Small, Journal Year: 2024, Volume and Issue: 20(47)

Published: Aug. 16, 2024

Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.

Language: Английский

Citations

20
Unveiling the Link Between Chronic Inflammation and Cancer DOI Creative Commons

Siddhant Tripathi,

Yashika Sharma, Dileep Kumar

et al.

Metabolism Open, Journal Year: 2025, Volume and Issue: 25, P. 100347 - 100347

Published: Jan. 9, 2025

The highly nuanced transition from an inflammatory process to tumorigenesis is of great scientific interest. While it well known that environmental stimuli can cause inflammation, less about the oncogenic modifications chronic inflammation in tissue microenvironment bring about, as how these set off pro-tumorigenic processes. It clear no matter where factors come from, maintaining encourages carcinogenesis. In addition encouraging angiogenesis and metastatic processes, sustaining survival proliferation malignant transformed cells, possibly altering efficacy therapeutic agents, negatively regulate antitumoral adaptive innate immune responses. Because has multiple pathways involved metastasis, gained recognition a marker cancer desirable target for therapy. Recent advances our knowledge molecular mechanisms drive cancer's progression demonstrate promotes metastasis while suppressing anti-tumor immunity. many solid tumor types, including breast, lung, liver cancer, stimulates activation oncogenes impairs body's defenses against tumor. Additionally, alters As tactical approach treatment, findings have underscored importance targeting pathways. This review highlights role development focusing on its impact progression, suppression, therapy resistance. examines current anti-inflammatory strategies, NSAIDs, cytokine modulators, STAT3 inhibitors, addressing their potential limitations. emphasizes need further research unravel complex linking identify targets specific subtypes.

Language: Английский

Citations

2
Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review DOI
Yasser Fakri Mustafa

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

1
Pro-Inflammatory Cytokines Transactivate Glycosylated Cytokine Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition to the Metastatic Phenotype DOI Open Access
Leili Baghaie, David A. Bunsick,

Emilyn B. Aucoin

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1234 - 1234

Published: April 5, 2025

Background/Objectives: The significance of cytokine signaling on cancer progression and metastasis has raised interest in research over the last few decades. Here, we analyzed effects three cytokines that previously reported are significantly upregulated rapidly after surgical removal primary breast, colorectal, prostate cancer. We also investigated regulation their cognate receptors. Methods: All experiments were conducted using PANC-1, SW620, MCF-7 cell lines, treated with different (TGF-β1, HGF, IL-6). effect these expression epithelial-mesenchymal transition (EMT) surface markers neuraminidase-1 activity was measured via fluorescent microscopy image analysis software. Results: findings show increase mesenchymal while reducing epithelial markers, corresponding to EMT process. A strong link between receptor Neu-1-MMP-9-GPCR crosstalk identified, suggesting binding leads increased Neu-1 subsequent pathway activation. Oseltamivir phosphate (OP) prevented sialic acid hydrolysis by (Neu-1), leading downregulation cascades. Conclusions: In concert previous work revealing role regulating other glycosylated receptors implicated proliferation EMT, targeting may provide effective treatment against a variety malignancies. Most significantly, patients specific inhibitors soon surgery improve our ability cure early-stage inhibiting process disrupting any residual population metastasize.

Language: Английский

Citations

1
Biophysical effects of Phellinus Linteus on hepatocellular carcinoma cells studied by atomic force microscopy DOI
Yuxi Huang, Fan Yang,

Chuanzhi Liu

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2025, Volume and Issue: 267, P. 113169 - 113169

Published: April 23, 2025

Language: Английский

Citations

0
Cancer cachexia: exploring parallels with other paraneoplastic syndromes DOI
Michael S. Yule,

Alan Ireland,

Barry Laird

et al.

Current Opinion in Supportive and Palliative Care, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Purpose of review Cancer cachexia (CC) is a paraneoplastic syndrome (PNS) that characterised by anorexia, weight loss, fatigue and reduced function. This explores the molecular drivers CC other PNS, identifying shared pathways highlighting unexplored gaps in research. Recent findings studies have provided further evidence pro-inflammatory cytokines, such as interleukin-6 tumour necrosis factor-α, central players both emphasising their role systemic effects like muscle wasting, lipolysis pyrexia. Despite these overlaps between syndromes, cytokine profiles vary across different cancer types with one study interplay multiple cytokines likely plays more significant phenotypes than individual cytokines. Mediators, parathyroid hormone related peptide vascular endothelial growth factor, which are typically associated malignant hyperkalaemia hypertrophic osteoarthropathy respectively, also been linked to cachexia, suggesting role. Summary highlights overlap PNS. Exploring mechanisms can bridge research improve treatment strategies. Similar insights may be gained examining conditions eating disorders, bariatric surgery sepsis.

Language: Английский

Citations

0
Integrated machine learning identifies a cellular senescence-related prognostic model to improve outcomes in uterine corpus endometrial carcinoma DOI Creative Commons

Changqiang Wei,

Shanshan Lin,

Yanrong Huang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Background Uterine Corpus Endometrial Carcinoma (UCEC) stands as one of the prevalent malignancies impacting women globally. Given its heterogeneous nature, personalized therapeutic approaches are increasingly significant for optimizing patient outcomes. This study investigated prognostic potential cellular senescence genes(CSGs) in UCEC, utilizing machine learning techniques integrated with large-scale genomic data. Methods A comprehensive analysis was conducted using transcriptomic and clinical data from 579 endometrial cancer patients sourced Cancer Genome Atlas (TCGA). subset 503 CSGs assessed through weighted gene co-expression network (WGCNA) alongside algorithms, including Gaussian Mixture Model (GMM), support vector - recursive feature elimination (SVM-RFE), Random Forest, eXtreme Gradient Boosting (XGBoost), to identify key differentially expressed genes. These genes underwent further construct a model. Results Our revealed two distinct molecular clusters UCEC differences tumor microenvironment survival Utilizing genes, model effectively stratified into high-risk low-risk categories. Patients group exhibited compromised overall presented immune profiles indicative progression. Crucially, demonstrated robust predictive performance validation an independent cohort. Conclusion The emphasized significance progression underscored efficacy developing reliable models. findings suggested that targeting holds promise strategy treatment, thus warranting investigation.

Language: Английский

Citations

1
Iturin A and Gramicidin A inhibit proliferation, trigger apoptosis, and regulate inflammation in breast cancer cells DOI
Pınar Altın Çelik, Ahmet Eken, Muazzez Derya-Andeden

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106121 - 106121

Published: Aug. 27, 2024

Language: Английский

Citations

0
Collagen IV/laminin-1 coated temozolomide-prodrug hydrogel for recruiting and eradicating residual glioma cells DOI

Yufu Zhu,

Jiaqi Jin, Yang Lü

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158616 - 158616

Published: Dec. 1, 2024

Citations

0
4-Pyridone-3-carboxamide-1-β-D-ribonucleoside Reduces Cyclophosphamide Effects and Induces Endothelial Inflammation in Murine Breast Cancer Model DOI Open Access
Paulina Mierzejewska,

Agnieszka Denslow,

Diana Papiernik

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 35 - 35

Published: Dec. 24, 2024

4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) is a nicotinamide derivative, considered new oncometabolite. 4PYR formation induced cytotoxic effect on the endothelium. Elevated blood concentration was observed in patients with cancer. Still, little known about metabolic and functional effects of this pathology. The study aimed to investigate whether toxic accumulation may affect activity anticancer therapy cyclophosphamide orthotropic model breast Female Balb/c mice were injected 4T1 cancer cells assigned into three groups: treated PBS (Control), cyclophosphamide-treated (+CP), 4PYR-treated (+4PYR), both CP(+4PYR+CP) for 28 days. Afterward, serum samples, liver, muscle, spleen, heart, lungs, aortas, tumor tissue collected analysis concentrations nucleotides, metabolites, its as well liver level cytochrome P450 enzymes. treatment caused elevation 4PYR, monophosphate adenine dinucleotide (NAD+) analog-4PYRAD. Blood 4PYRAD +4PYR+CP reduced comparison +4PYR. Tumor growth final mass significantly decreased +CP did not differ +4PYR Control. However, we substantial increase these parameters compared +CP. extracellular adenosine deamination rate measured assess vascular inflammation, it higher than Treatment CP highest ATP hydrolysis rate. administration significant CYP2C9 reduction CYP3A4 Control In additional experiments, healthy without cancer, (4PYR w/o cancer) (Control cancer), where an proinflammatory cytokine expression interferes induces pro-inflammatory shift endothelial enzymes, probably by affecting metabolism This observation have crucial implications various drugs metabolized P450.

Language: Английский

Citations

0