When a negative (charge) is not a positive: sialylation and its role in cancer mechanics and progression DOI Creative Commons

Issa Funsho Habeeb,

Toheeb Eniola Alao,

Diogo Delgado

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 19, 2024

Sialic acids and sialoglycans are critical actors in cancer progression metastasis. These terminal sugar residues on glycoproteins glycolipids modulate key cellular processes such as immune evasion, cell adhesion, migration. Aberrant sialylation is driven by overexpression of sialyltransferases, resulting hypersialylation surfaces well enhancing tumor aggressiveness. Sialylated glycans alter the structure glycocalyx, a protective barrier that fosters detachment, migration, invasion. This bulky glycocalyx also increases membrane tension, promoting integrin clustering downstream signaling pathways drive proliferation They play role evasion binding to Siglecs, inhibitory receptors cells, which transmit signals protect cells from immune-mediated destruction. Targeting presents promising therapeutic opportunity understand complex roles sialic mechanics progression, crucial for developing novel diagnostic strategies can disrupt these improve treatment outcomes.

Language: Английский

Glycosylated nanoplatforms: From glycosylation strategies to implications and opportunities for cancer theranostics DOI
Iman Zare,

Shahrzad Zirak Hassan Kiadeh,

Ayşegül Varol

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 158 - 178

Published: May 29, 2024

Language: Английский

Citations

12
Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma DOI Creative Commons
Jianlin Chen, Yue Zheng, Zhen Wang

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Language: Английский

Citations

1
Sialylation in the gut: From mucosal protection to disease pathogenesis DOI

Xueni Ma,

Muyang Li, Xiaochun Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122471 - 122471

Published: July 9, 2024

Language: Английский

Citations

3
Blockade of Sialylation with Decrease in Polysialic Acid Levels Counteracts Transforming Growth Factor β1-Induced Skin Fibroblast-to-Myofibroblast Transition DOI Creative Commons
Bianca Saveria Fioretto, Irene Rosa, Alessia Tani

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1067 - 1067

Published: June 19, 2024

Aberrant sialylation with overexpression of the homopolymeric glycan polysialic acid (polySia) was recently reported in fibroblasts from fibrotic skin lesions. Yet, whether such a rise polySia levels or general may be functionally implicated profibrotic activation and their transition to myofibroblasts remains unknown. Therefore, we herein explored inhibition could interfere process fibroblast-to-myofibroblast induced by master mediator transforming growth factor β1 (TGFβ1). Adult human were pretreated competitive pan-sialyltransferase inhibitor 3-Fax-peracetyl-Neu5Ac (3-Fax) before stimulation recombinant TGFβ1, then analyzed for expression, cell viability, proliferation, migratory ability, acquisition myofibroblast-like morphofunctional features. Skin fibroblast TGFβ1 resulted polySia, which effectively blunted 3-Fax pre-administration. Pretreatment efficiently lessened TGFβ1-induced migration, changes morphology, phenotypic functional differentiation into myofibroblasts, as testified significant reduction FAP, ACTA2, COL1A1, COL1A2, FN1 gene α-smooth muscle actin, N-cadherin, FN-EDA protein levels, well reduced contractile capability. Moreover, pre-administered displayed decrease Smad3-dependent canonical signaling. Collectively, our vitro findings demonstrate first time that aberrant increased has role suggest sialyltransferase might offer new therapeutic opportunities against fibrosis.

Language: Английский

Citations

2
Mechanistic and Therapeutic Implications of Protein and Lipid Sialylation in Human Diseases DOI Open Access
Xiaotian Zhong, Aaron M. D’Antona, Jason C. Rouse

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11962 - 11962

Published: Nov. 7, 2024

Glycan structures of glycoproteins and glycolipids on the surface glycocalyx luminal sugar layers intracellular membrane compartments in human cells constitute a key interface between biological processes external environments. Sialic acids, class alpha-keto acid sugars with nine-carbon backbone, are frequently found as terminal residues these glycoconjugates, forming critical components layers. Changes status content cellular sialic acids closely linked to many diseases such cancer, cardiovascular, neurological, inflammatory, infectious, lysosomal storage diseases. The molecular machineries responsible for biosynthesis sialylated glycans, along their interacting partners, important therapeutic strategies targets drug development. purpose this article is comprehensively review recent literature provide new scientific insights into mechanisms implications sialylation across various Recent advances clinical developments acid-related therapies also summarized discussed.

Language: Английский

Citations

0
When a negative (charge) is not a positive: sialylation and its role in cancer mechanics and progression DOI Creative Commons

Issa Funsho Habeeb,

Toheeb Eniola Alao,

Diogo Delgado

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 19, 2024

Sialic acids and sialoglycans are critical actors in cancer progression metastasis. These terminal sugar residues on glycoproteins glycolipids modulate key cellular processes such as immune evasion, cell adhesion, migration. Aberrant sialylation is driven by overexpression of sialyltransferases, resulting hypersialylation surfaces well enhancing tumor aggressiveness. Sialylated glycans alter the structure glycocalyx, a protective barrier that fosters detachment, migration, invasion. This bulky glycocalyx also increases membrane tension, promoting integrin clustering downstream signaling pathways drive proliferation They play role evasion binding to Siglecs, inhibitory receptors cells, which transmit signals protect cells from immune-mediated destruction. Targeting presents promising therapeutic opportunity understand complex roles sialic mechanics progression, crucial for developing novel diagnostic strategies can disrupt these improve treatment outcomes.

Language: Английский

Citations

0