Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189347 - 189347
Published: May 1, 2025
Language: Английский
Frontiers in Surgery, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 14, 2024
One study by Zheng et al. (2023) provides a detailed comparative analysis of laparoscopicassisted transanal natural orifice specimen extraction (NOSE) versus conventional laparoscopic surgery (CLS) for sigmoid and rectal cancer (1). Among 121 patients, NOSE was associated with shorter total incision length, highlighting its cosmetic advantage. However, this benefit offset longer operation time compared to CLS. Importantly, there were no significant differences in postoperative complications, such as bacterial culture positivity, intra-abdominal infections, or anastomotic leakage, nor overall survival (OS) disease-free (DFS) outcomes between the two groups. The findings suggest that while may be particularly suitable patients who prioritize outcomes, extended operative duration warrants careful consideration clinical decision-making.In another contribution, Hongan conducted systematic review metaanalysis assess impact adjuvant chemotherapy (ACT) on nodenegative CRC focus presence perineural invasion (PNI) (2). Their revealed ACT significantly improved OS DFS PNI, hazard ratios (HR) 0.52 0.53, respectively. did not affect without PNI. These underscore potential beneficial intervention also suggesting it confer some advantage those PNI.Colorectal (CRC) is characterized genetic, anatomical, transcriptional diversity. tumor microenvironment (TME) plays critical role prognosis treatment outcomes. It consists various cellular components like cancerassociated fibroblasts, tumor-associated macrophages, regulatory T cells, well extracellular elements contribute therapeutic resistance through mechanisms fibrosis enzymatic degradation. Given influence therapy efficacy, TME presents promising area drug discovery, ongoing research focused targeting improve strategies (3).Colorectal BRAF V600E mutation aggressive resistant therapies, largely due enhanced MAPK pathway activation. Although inhibitors have shown limited success, combining these immune checkpoint (ICIs) offers promise, microsatellite instability-high (MSI-H) tumors ( 4).The Jiang 2023) investigated relationship collagen structure Immunoscore (5). Using multiphoton imaging, they developed signature from 327 stage I-III which strongly correlated Immunoscore. A nomogram subsequently constructed, integrating clinicopathological predictors. This demonstrated high predictive accuracy prognosis, high-risk II III valuable tool identifying might most chemotherapy. highlights biomarker immunological activity within TME, offering novel approach CRC. pT4M0 colon adenocarcinoma (COAD), analyzing optimal using data SEER database (6). study, included 8,843 received combined had better 3-year cancer-specific (CSS) rates underwent alone. developed, incorporating variables age, race, N stage, serum CEA levels, differentiation, number resected lymph nodes, demonstrating strong accuracy. emphasizes importance chemoradiotherapy improving long-term COAD patients.In realm Bai utility contrast-enhanced ultrasound (CEUS) evaluating response neoadjuvant locally advanced (LARC) (7). retrospective 83 found certain CEUS parameters, peak intensity (PI) under curve (AUC), Patients higher PI AUC values, along poorly differentiated tumors, worse progression-free (PFS). quantitative noninvasive predicting LARC patients.Zhong (2024) examined factors achieving pathologic complete (pCR) treated chemoradiation (nCRT) (8). identified gross volume (GTV) differentiation predictors pCR, threshold 21.1 cm³ showing sensitivity pCR. GTV are crucial preoperative assessments, helping clinicians tailoring plans more effectively.Gallo reported that, minimally invasive techniques SILS transformed colorectal surgery, patient reducing recovery times hospital stays. Emerging technologies, including robotic platforms AI integration, further enhancing surgical precision, setting future advancements care (9).A multicenter 5,398 surgeries, independent risk sex, BMI, location, (10). leak incidence 10.2%, 2.6% 30-day leakrelated mortality. While protective stomas reduce leakage rates, effectively minimized severity need reoperation. introduced prediction model, RALAR score, individual guide decisions stoma construction post-resection. assist optimizing planning outcomes.A Zhao pan-immune-inflammation value (PIV) other features assessment (11). PIV, when markers CA19-9, efficacy staging immune-inflammatory biomarkers.Lastly, Verras Mulita explored butyrylcholinesterase (BChE) site infections (SSIs) after (12). prospective low BChE levels first third days SSIs. suggests could serve early marker at increased infection, thereby enabling timely targeted interventions.Benign diseases include variety conditions adenomatous polyps, diverticular disease, inflammatory bowel disease (IBD) (13). pose challenges management, accurately lesions require can monitored safely. Over-diagnosis lead unnecessary interventions, increasing anxiety, complications healthcare costs. Additionally, managing diseases, diverticulitis, adds complexity. Future directions should screening techniques, imaging molecular diagnostics characterization lesions. Research into biomarkers detection stratification IBD personalized approaches.In daily practice, recent studies enhance decision-making assessments treatments. For instance, pan-immuneinflammation useful progression cancer. score aids guiding decisions. help predict interventions outcomes.In conclusion, collectively advance our understanding new prognostic tools insights effectiveness strategies. As medicine continues evolve, integration biomarkers, tailored approaches will essential disorders.
Language: Английский
Citations
4
Journal of Experimental & Clinical Cancer Research, Journal Year: 2025, Volume and Issue: 44(1)
Published: March 11, 2025
Abstract Background Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In quest to enhance therapeutic efficacy in CRC, interplay between genetic mutations and RT sensitivity has emerged as a pivotal enigmatic area. Methods We harness fidelity of patient-derived organoids (PDOs) dissect molecular landscape radiosensitivity, with particular emphasis on BRAF V600E mutations. To further investigate, cohort 9 -mutant 10 wild-type PDOs constructed systematically assess radiobiological traits including morphology, cell viability, DNA damage, while also evaluating their responses chemotherapy chemoradiotherapy. Results Our systematic investigation unveils profound correlation mutation status radioresistance, which validated by clinical responses. Intriguingly, exhibit reduced conventional chemotherapy, demonstrate enhanced response combined chemoradiotherapy, characterized increased apoptosis. The results are through vivo analyses using organoid xenograft mouse models aligned patient outcomes. Conclusions This study outlines distinct profile underscoring critical role radiotherapy comprehensive strategies. work not only advances our understanding CRC but paves way precision medicine, offering valuable insights decision-making management CRC.
Language: Английский
Citations
0
Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149433 - 149433
Published: March 1, 2025
Language: Английский
Citations
0
ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
Language: Английский
Citations
0
Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(02), P. 1017 - 1024
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189347 - 189347
Published: May 1, 2025
Language: Английский
Citations
0