Early life gut microbiome and its impact on childhood health and chronic conditions

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 7, 2025

The development of the gut microbiome is crucial to human health, particularly during first three years life. Given its role in immune development, disturbances establishment process may have long term consequences. This review summarizes evidence for these claims, highlighting compositional changes this critical period life as well factors that affect development. Based on and animal data, we conclude early-life a determinant long-term impacting physiological, metabolic, processes. field faces challenges. Some challenges are technical, such lack standardized stool collection protocols, inconsistent DNA extraction methods, outdated sequencing technologies. Other methodological: small sample sizes, longitudinal studies, poor control confounding variables. To address limitations, advocate more robust research methodologies better understand microbiome's health disease. Improved methods will lead reliable studies deeper understanding impact outcomes.

Language: Английский

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In vitro dynamic digestion properties and fecal fermentation of Dictyophora indusiata polysaccharide: Structural characterization and gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136713 - 136713

Published: Oct. 18, 2024

Language: Английский

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Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Sleep-promoting mechanism of Lactobacillus plantarum P8 combined with traditional Chinese medicine revealed by network pharmacology, microbiome, metabolome, and transcriptome analyses

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106606 - 106606

Published: April 1, 2025

Language: Английский

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Short-chain fatty acids—a key link between the gut microbiome and T-lymphocytes in neonates?

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Infancy is a vulnerable and critical phase in the acquisition of gut microbiome establishment immune function. Short-chain fatty acids (SCFAs), such as acetate, propionate butyrate, are compounds mostly produced by through various metabolic pathways play an indispensable role connecting adaptive system. This review aims to summarise recent findings regarding intricate relationship between SCFAs, microbiome, T lymphocytes with focus on early life interactions. The paper discusses factors affecting neonatal especially human milk versus formula milk, how these influence SCFA concentrations feces, which turn directly impact cell development Despite advances understanding derived SCFAs adults, significant knowledge gap remains translating neonates exploring utility potential therapeutic intervention inflammatory complications preterm term neonates. IMPACT: highlights applications short-chain (SCFAs) care, particularly preventing treating conditions. could lead new treatment strategies for conditions like NEC other immune-mediated disorders By identifying gaps research, this helps future investigations toward mechanisms specifically neonates, potentially leading age-appropriate interventions. Understanding early-life (such feeding methods development) system inform public health policies recommendations infant nutrition care practices.

Language: Английский

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Gut Microbiota-Derived Metabolites and Their Role in the Pathogenesis of Necrotizing Enterocolitis in Preterm Infants: A Narrative Review

Metabolites, Journal Year: 2024, Volume and Issue: 14(11), P. 570 - 570

Published: Oct. 23, 2024

: Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that occurs predominantly in premature infants and characterized by the inflammation necrosis of intestine, showing high morbidity mortality rates. Despite decades research efforts, specific treatment currently lacking, preventive strategies are mainstays care. This review aims to help understand complex interplay between gut microbiota their metabolites NEC pathogenesis. In particular, we focused on how these factors can influence health, immune responses, intestinal barrier integrity.

Language: Английский

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Role of gut microbiome in developing necrotizing enterocolitis

Folia Microbiologica, Journal Year: 2024, Volume and Issue: 70(1), P. 197 - 204

Published: Nov. 17, 2024

Language: Английский

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