Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148

Published: March 28, 2025

Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing

Language: Английский

Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(7)

Published: April 1, 2025

Abstract The field of extracellular vesicles (EVs) is advancing rapidly, and this review aims to synthesize the latest research connected EVs gastrointestinal tract. We will address new emerging roles for derived from internal sources such as pancreas immune system how these miniature messengers alter organismal health or inflammatory response within GI examine what known about external dietary bacterial immense anti‐inflammatory, immune‐modulatory, proliferative potential nano‐sized information carriers. EV interactions with intestinal colonic epithelium associated cells at homeostatic disease states, necrotizing enterocolitis (NEC) bowel (IBD) also be covered. discuss are being leveraged therapeutics drug delivery conclude a series unanswered questions in field.

Language: Английский