The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 12, 2022

Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the global spread of Coronavirus Disease 2019 (COVID-19) and an increase complications including Distress (ARDS). Due to lack therapeutic options for Syndrome, recent attention focused on differentiating hyper- hypo-inflammatory phenotypes ARDS help define effective strategies. Interleukin 8 (IL-8) is a pro-inflammatory cytokine that role neutrophil activation been identified within pathogenesis progression this disease. The aim review highlight IL-8 as biomarker prognostic factor modulating hyperinflammatory response ARDS. crucial lung inflammation disease might suggest possible new target efficiently modulate

Language: Английский

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The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 7, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless infections and caused millions of deaths since its emergence 2019. Coronavirus disease 2019 (COVID-19)-associated mortality is by uncontrolled inflammation, aberrant immune response, cytokine storm, an imbalanced hyperactive system. The storm further results multiple organ failure lung immunopathology. Therefore, any potential treatments should focus on the direct elimination viral particles, prevention strategies, mitigation (hyperactive) This review focuses secretions innate adaptive responses against COVID-19, including interleukins, interferons, tumor necrosis factor-alpha, other chemokines. In addition to focus, we discuss immunotherapeutic approaches based relevant pathophysiological features, systemic response SARS-CoV-2, data from recent clinical trials experiments COVID-19-associated storm. Prompt use these cytokines as diagnostic markers aggressive management can help determine morbidity mortality. prophylaxis rapid appear significantly improve outcomes. For reasons, this study aims provide advanced information facilitate innovative strategies survive COVID-19 pandemic.

Language: Английский

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The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: Feb. 2, 2022

Abstract The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy effective vaccine is critical to overcoming severe acute respiratory syndrome 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes SARS-CoV-2 may help propose antiviral drugs vaccines. Several receptors have been demonstrated for the interaction spike (S) protein with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands Eph receptors, neuropilin 1 (NRP-1), P2X7, CD147. expression these in central nervous system (CNS) make CNS prone invasion, leading neurodegenerative diseases. present review provides potential pathological mechanisms infection CNS, cytokines involved neuroinflammatory conditions. Moreover, it explains several disorders associated COVID-19. Finally, we suggest inflammasome JaK inhibitors as strategies

Language: Английский

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Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16− Monocytes From COVID-19 Patients

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 14, 2022

The poor outcome of the coronavirus disease-2019 (COVID-19), caused by SARS-CoV-2, is associated with systemic hyperinflammatory response and immunopathology. Although inflammasome oxidative stress have independently been implicated in COVID-19, it poorly understood whether these two pathways cooperatively contribute to disease severity. Herein, we found an enrichment CD14highCD16- monocytes displaying activation evidenced caspase-1/ASC-speck formation severe COVID-19 patients when compared mild ones healthy controls, respectively. Those cells also showed aberrant levels mitochondrial superoxide lipid peroxidation, both hallmarks response, which strongly correlated caspase-1 activity. In addition, that NLRP3 inflammasome-derived IL-1β secretion SARS-CoV-2-exposed vitro was partially dependent on peroxidation. Importantly, altered responses persisted after short-term patient recovery. Collectively, our findings suggest stress/NLRP3 signaling pathway as a potential target for host-directed therapy mitigate early hyperinflammation its long-term outcomes.

Language: Английский

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Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4 ⁺ T Cell Responses

Journal of Virology, Journal Year: 2022, Volume and Issue: 96(6)

Published: Feb. 2, 2022

Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe acute respiratory syndrome 2 (SARS-CoV-2) and influenza A virus (IAV) is a major concern for public health. However, immunopathogenic events occurring with coinfections SARS-CoV-2 IAV remain unclear. Here, we report pathogenic immunological consequences H1N1 in K18-hACE2 transgenic mouse model. Compared single infection or IAV, not only prolonged primary period but also increased immune cell infiltration inflammatory cytokine levels bronchoalveolar lavage fluid leading to pneumonia lung damage. Moreover, caused lymphopenia peripheral blood, resulting reduced total IgG, neutralizing antibody titers, CD4

Language: Английский

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Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Nature Immunology, Journal Year: 2023, Volume and Issue: 24(4), P. 604 - 611

Published: March 6, 2023

Abstract Infection with severe acute respiratory syndrome coronavirus 2 associates diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors associated adverse disease 2019 (COVID-19) outcomes. Here we discovered that against specific chemokines were omnipresent post-COVID-19, favorable outcome negatively correlated the development of long COVID at 1 yr post-infection. Chemokine also present in HIV-1 infection autoimmune disorders, but they targeted different compared COVID-19. Monoclonal derived from COVID-19 convalescents bound to chemokine N-loop impaired cell migration. Given role orchestrating trafficking, naturally arising may modulate inflammatory response thus bear therapeutic potential.

Language: Английский

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The roles of critical pro‐inflammatory cytokines in the drive of cytokine storm during SARS‐CoV‐2 infection

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(4)

Published: April 1, 2023

Abstract In patients with severe COVID‐19, acute respiratory distress syndrome (ARDS), multiple organ dysfunction (MODS), and even mortality can result from cytokine storm, which is a hyperinflammatory medical condition caused by the excessive uncontrolled release of pro‐inflammatory cytokines. High levels numerous crucial cytokines, such as interleukin‐1 (IL‐1), IL‐2, IL‐6, tumor necrosis factor‐α, interferon (IFN)‐γ, IFN‐induced protein 10 kDa, granulocyte‐macrophage colony‐stimulating factor, monocyte chemoattractant protein‐1, IL‐10 so on, have been found in COVID‐19. They participate cascade amplification pathways responses through complex inflammatory networks. Here, we review involvements these critical cytokines SARS‐CoV‐2 infection discuss their potential roles triggering or regulating help to understand pathogenesis So far, there rarely effective therapeutic strategy for storm besides using glucocorticoids, proved fatal side effects. Clarifying key involved network will develop an ideal intervention, neutralizing antibody certain inhibitor some signal pathways.

Language: Английский

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Monocytes and macrophages: Origin, homing, differentiation, and functionality during inflammation

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29686 - e29686

Published: April 1, 2024

Monocytes and macrophages are essential components of innate immune system have versatile roles in homeostasis immunity. These phenotypically distinguishable mononuclear phagocytes play distinct different stages, contributing to the pathophysiology various forms making them a potentially attractive therapeutic target inflammatory conditions. Several pieces evidence supported role cell surface receptors expressed on these cells their downstream signaling molecules initiating perpetuating response. In this review, we discuss current understanding monocyte macrophage biology inflammation, highlighting chemoattractants, inflammasomes, integrins function monocytes during events inflammation. This review also covers recent interventions targeting at cellular molecular levels.

Language: Английский

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Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

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Pathological Interplay of NF-κB and M1 Macrophages in Chronic Inflammatory Lung Diseases

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155903 - 155903

Published: March 7, 2025

Language: Английский

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