Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development DOI Open Access
Shinya Hasegawa, Yutaka Shoji, Mamoru Kato

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11191 - 11191

Published: Oct. 17, 2024

Determining a novel etiology and mechanism of human cancer requires extraction characteristic mutational signatures derived from chemical substances. This study explored the N-nitroso bile acid conjugates using Salmonella strains. Exposing S. typhimurium TA1535 to N-nitroso-glycine/taurine induced predominance C:G T:A transitions. Two signatures, B1 B2, were extracted. Signature is associated with N-nitroso-glycine conjugates, while B2 linked N-nitroso-taurine conjugates. revealed strong transcribed strand bias GCC GCT contexts, mutation pattern in YG7108, which lacks O6-methylguanine DNA methyltransferases, matched that wild-type strain TA1535, suggesting O6-methyl-deoxyguanosine contributes mutations relevant regions. COSMIC database-based similarity analysis closely resembled SBS42, occupational cholangiocarcinoma caused by overexposure 1,2-dichlolopropane (1,2-DCP) and/or dichloromethane (DCM). Moreover, inflammatory response pathway was 1,2-DCP exposure cholangiocyte cell line, iNOS expression positive cholangiocarcinomas. These results suggest triggers an biliary epithelial cells upregulating conjugate production, resulting via adduct formation.

Language: Английский

Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide DOI Creative Commons
Ruth Nussinov, Bengi Ruken Yavuz, Habibe Cansu Demirel

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: July 2, 2024

The connection and causality between cancer neurodevelopmental disorders have been puzzling. How can the same cellular pathways, proteins, mutations lead to pathologies with vastly different clinical presentations? And why do individuals disorders, such as autism schizophrenia, face higher chances of emerging throughout their lifetime? Our broad review emphasizes multi-scale aspect this type reasoning. As these examples demonstrate, rather than focusing on a specific organ system or disease, we aim at new understanding that be gained. Within framework, our calls attention computational strategies which powerful in discovering connections, causalities, predicting outcomes, are vital for drug discovery. Thus, centering features, draw rapidly increasing data molecular level, including mutations, isoforms, three-dimensional structures, expression levels respective disease-associated genes. Their integrated analysis, together chromatin states, delineate how, despite being connected, differ, how symptoms. Here, seek uncover cancer, pediatric tumors, tantalizing questions raises.

Language: Английский

Citations

7
The Role of Proteomics and Genomics in the Development of Colorectal Cancer Diagnostic Tools and Potential New Treatments DOI

Gaurav Paraskar,

Sankha Bhattacharya,

Kuttiappan Anitha

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

Citations

0
Exploring the potential of multiomics liquid biopsy testing in the clinical setting of lung cancer DOI
Andrea Gottardo,

Tancredi Didier Bazan Russo,

Alessandro Perez

et al.

Cytopathology, Journal Year: 2024, Volume and Issue: 35(6), P. 664 - 670

Published: June 1, 2024

The transformative role of artificial intelligence (AI) and multiomics could enhance the diagnostic prognostic capabilities liquid biopsy (LB) for lung cancer (LC). Despite advances, transition from tissue biopsies to more sophisticated, non-invasive methods like LB has been impeded by challenges such as heterogeneity biomarkers low concentration tumour-related analytes. advent - enabled deep learning algorithms offers a solution allowing simultaneous analysis various analytes across multiple biological fluids, presenting paradigm shift in diagnostics. Through multi-marker, multi-analyte multi-source approaches, this review showcases how AI are identifying clinically valuable biomarker combinations that correlate with patients' health statuses. However, path towards clinical implementation is fraught challenges, including study reproducibility lack methodological standardization, thus necessitating urgent solutions solve these common issues.

Language: Английский

Citations

3
Review: Merging from traditional to potential novel breast cancer biomarkers DOI Creative Commons
Hanan Alismail

Journal of King Saud University - Science, Journal Year: 2024, Volume and Issue: 36(11), P. 103551 - 103551

Published: Nov. 24, 2024

Language: Английский

Citations

1
Integrated explainable machine learning and multi-omics analysis for survival prediction in cancer with immunotherapy response DOI
Alphonse Houssou Hounye, Li Xiong, Muzhou Hou

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

Citations

1
The Role of Integrated Bioinformatics in Cancer Research: Transforming Genomic Insights into Precision Medicine DOI
Marjanu Hikmah Elias, Nur Zaireena Zainal, Nazefah Abdul Hamid

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Whole Genome Sequencing Analysis of Model Organisms Elucidates the Association Between Environmental Factors and Human Cancer Development DOI Open Access
Shinya Hasegawa, Yutaka Shoji, Mamoru Kato

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11191 - 11191

Published: Oct. 17, 2024

Determining a novel etiology and mechanism of human cancer requires extraction characteristic mutational signatures derived from chemical substances. This study explored the N-nitroso bile acid conjugates using Salmonella strains. Exposing S. typhimurium TA1535 to N-nitroso-glycine/taurine induced predominance C:G T:A transitions. Two signatures, B1 B2, were extracted. Signature is associated with N-nitroso-glycine conjugates, while B2 linked N-nitroso-taurine conjugates. revealed strong transcribed strand bias GCC GCT contexts, mutation pattern in YG7108, which lacks O6-methylguanine DNA methyltransferases, matched that wild-type strain TA1535, suggesting O6-methyl-deoxyguanosine contributes mutations relevant regions. COSMIC database-based similarity analysis closely resembled SBS42, occupational cholangiocarcinoma caused by overexposure 1,2-dichlolopropane (1,2-DCP) and/or dichloromethane (DCM). Moreover, inflammatory response pathway was 1,2-DCP exposure cholangiocyte cell line, iNOS expression positive cholangiocarcinomas. These results suggest triggers an biliary epithelial cells upregulating conjugate production, resulting via adduct formation.

Language: Английский

Citations

0