Microbial-Derived Antioxidants in Intestinal Inflammation: A Systematic Review of Their Therapeutic Potential

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 321 - 321

Published: March 6, 2025

The potential of microbial-derived antioxidants to modulate intestinal inflammation is increasingly recognized, which especially important in inflammatory bowel diseases (IBD). Oxidative stress, a major contributor chronic inflammation, the result an imbalance between production reactive oxygen species (ROS) and body's antioxidant defenses. This systematic review explores role alleviating IBD. Among main findings are certain compounds, such as exopolysaccharides (EPS) short-chain fatty acids (SCFAs), have demonstrated their ability neutralize ROS strengthen integrity barrier, thereby attenuating responses. These offer dual benefit mitigating oxidative stress rebalancing gut microbiota, often disrupted Evidence from preclinical clinical studies provides better understanding mechanisms involved effects these microbial antioxidants. Conventional treatments for IBD primarily focus on immune modulation. In this context, integration could complementary approach by addressing both damage dysbiosis. Further research trials essential establish standardized treatment guidelines clarify long-term efficacy promising therapeutic agents.

Language: Английский

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Vaginal Administration of Progesterone in Twin Gestation: Influence on Bone Turnover and Oxidative Stress

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 324 - 324

Published: March 8, 2025

Twin pregnancies, with higher incidences of preterm birth, are becoming more prevalent. Progesterone has shown effectiveness in the prevention labour, though other factors related to pregnancy and neonatal health may be affected by this hormone have not been previously addressed. This study aims evaluate impact progesterone administration on oxidative stress bone turnover during twin gestation investigate associations some maternal/neonatal variables interest. Women pregnant twins were recruited "Virgen de la Arrixaca" University Hospital randomly assigned two groups: control (n = 49) 50). A total 600 mg/day was vaginally administered from 11 14 34 weeks gestation. Blood samples taken first (T1) third trimester (T3), analyzing biomarkers turnover. Most markers experiment significant changes significantly increased (p < 0.05) levels osteocalcin T3 decreased sclerostin. Regarding stress, group, unlike showed no increase between T1 T3. In conclusion, results show that could maternal formation modulate stress.

Language: Английский

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Modulating the Gut Microbiota to Combat Drug-Induced Liver Injury: A New Frontier in Hepatic Health

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Drug-induced liver injury (DILI) encompasses a spectrum of damage caused by pharmaceuticals or their metabolites, ranging from mild, asymptomatic dysfunction to severe, acute failure. The diagnosis DILI primarily depends on thorough understanding its clinical presentation and the careful exclusion alternative etiologies injury. This chapter provides comprehensive analysis epidemiology, pathogenesis, therapeutic approaches DILI, aiming deepen this complex condition. Furthermore, it investigates emerging role gut microbiota in pathogenesis offering novel insights potential avenues for future interventions.

Language: Английский

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Plant-based antioxidant peptides: impact on oxidative stress and gut microbiota

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: April 12, 2025

Plant-based peptides can be obtained from natural and climate-friendly sources. These show various bioactivities including antioxidant activity. Oxidative stress has an impact on the gut microbiota causing inflammation, insulin resistance, osteoporosis, cancer, several chronic diseases like type 2 diabetes, arthritis, hypertension, atherosclerosis. Therefore, may significantly affect oxidative as a potential alternative to conventional medication. The production of plant-based protein sources through innovative approaches provide promising strategies improve microbiota. Recent studies in (PBAP) focus their advanced identification characterization techniques, structure-activity relationship, improvement extraction purification, cellular molecular mechanisms, specific health applications preventing managing conditions with microbiota, commercial nutraceuticals. Short-chain fatty acids reactive sulfur species are gut-derived metabolites that metabolic function by modulating immune system. This review highlights influence food oxidants PBAP-induced modulation Moreover, PBAP challenges application will discussed.

Language: Английский

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The effects of a modified Mediterranean diet on gut microbiota and clinical outcomes in patients with metastatic colorectal cancer undergoing first-line chemotherapy with either anti-EGFR or anti-VEGF agent: protocol for a randomized pilot study (Preprint)

Published: Feb. 21, 2025

the gut microbiota is attracting increasing interest as an initiator of colorectal cancer. It has been observed that microbial imbalance in and cancer tissue facilitated by a Western type diet, rich meat, sugars, refined grains, while Mediterranean low saturated fat fibers, promotes eubiosis, results reduced risk developing to analyze compare patients with metastatic undergoing first-line chemotherapy +/- biological agent (anti-EGFR or anti-VEGF), receiving either free standard modified diet. this pilot non-drug, interventional prospective, randomized, controlled, single-center, open-label trial. Patients (n=40) will be randomized 1:1 diet Blood fecal samples collected at baseline control visits, for metagenomic metabolomic analysis. The primary endpoint Firmicutes/Bacteroidetes ratio after completion third cycle (time T1). Secondary endpoints are: a) percentage experiencing gastrointestinal side effects T1; b) grade 3/4 c) changes ratio, overall microbiome composition, metabolome T1, sixth (T2) versus baseline. trial received ethics approval on July 24th 2024. By January 2025, 7 participants have recruited. study conclude visit T2 last enrolled patient. Results are expected published October 2028. potential provide critical insights into role modifying microbiota, diminishing chemotherapy-related effects, possibly enhancing therapeutic efficacy Additionally, data may pave way future research immunotherapy, potentially influencing both clinical practice public health strategies. Clinicaltrial.gov NCT06794931 (https://clinicaltrials.gov/search?term=NCT06794931)

Language: Английский

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Utilization of Safflower Oil Byproducts: Phenylpropanoid Amides of 5‐Hydroxytryptamine (PAHA)‐Enriched Extract as a Solution for Antioxidant and Inflammatory Pathway Modulation

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(5)

Published: May 1, 2025

ABSTRACT Safflower seed oil is one of the eight major resources worldwide, generating substantial byproducts after extraction each year. Efficient recycling and utilization these are critical for sustainability. This study explored potential use safflower coating by isolating bioactive compounds evaluating their functionality. Extraction methods to isolate phenylpropanoid amides 5‐hydroxytryptamine (PAHA), specifically coumaroyl‐5‐hydroxytryptamine (CS) feruloyl‐5‐hydroxytryptamine (FS), were first optimized results demonstrated that PAHA was highly presented in coating. The bioactivity systematically evaluated, showing extract exhibited antioxidant capacity. In vitro anti‐inflammatory assays PAHA‐enriched had remarked inhibitive capability on bovine serum albumin denaturation, erythrocyte membrane lysis, lipoxygenase (LOX) activity. an IPEC‐J2 cell model, significantly attenuated E. coli ‐induced inflammatory responses, resulting reduced expression genes proinflammatory markers IL‐1α, IL‐6, TNF‐α, COX‐2. Further analysis molecular docking suggesting strong binding affinities between two independent components (CS FS) key enzymes COX‐2 5‐LOX. current revealed excellent from coating, which could be utilized future as a naturally derived dual COX/LOX inhibitor food preservatives or functional food.

Language: Английский

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Plasma Bacterial Metabolites in Crohn’s Disease Pathogenesis and Complications

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 74 - 74

Published: Dec. 28, 2024

Background/Objectives: Crohn’s disease is known for being associated with an abnormal composition of the bacterial flora, dysbiosis and intestinal function disorders. Metabolites produced by gut microbiota play a pivotal role in pathogenesis CD, presence unspecific extraintestinal manifestations. Methods: The aim this study was determination level metabolites blood plasma patients disease. CD (29) healthy individuals (30) were recruited study. Bacterial (SCFAs TMAO panel) measured liquid chromatography–mass spectrometry system. Results: A significant correlation (p-value < 0.05) between obtained three eight tested SCFAs; acetic acid (reduced CD; FC 1.7; AUC = 0.714), butyric (increased; 0.68; 0.717), 2MeBA (FC 1.168; 0.702), indoxyl 0.624). concentration CA 0.82) choline 0.78) significantly disturbed according to biological treatment. Choline 1.28) also treated glucocorticoids. In total, 68.97% presented manifestations (EIMs) disease, mainly osteoarticular complications. BA statistically elevated 0.602) manifestations, while group complications, difference betaine 1.647) observed. Conclusions: analyzed may help diagnostic process, monitoring course treatment, lowly invasive way, as biomarkers after additional research on larger patients.

Language: Английский

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