Application of Angelica archangelica Phytomaterials as Inhibitors of SARS‐CoV‐2 Main Protease Receptor

Macromolecular Symposia, Journal Year: 2025, Volume and Issue: 414(1)

Published: Feb. 1, 2025

Abstract The proteins N and M, 3′‐5′ exoribonuclease (nsp14), viral proteases, RNA dependent polymerase (RdRp) are required for different stages of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) replication. For many antiviral therapies, these thus desirable targets. Due to the primary protease's differences from human it is thought be a suitable therapeutic target. Phytochemicals with characteristics possible strong weapons in fight against SAR‐CoV‐2. Coumarins one type phytochemical found Angelica archangelica L. that can possibly utilized produce an alternative natural molecule. Forty‐six bioactive phytochemicals selected A. plant have effect SARS‐CoV‐2 protease. From screened compounds, terpinen‐4‐ol coniferyl ferulate exhibit molecular bonding interaction docking study binding energies (−8.82) (−10.11) kcal mol −1 main protease receptor protein (pdb id: 6lu7 6w63) SARS‐CoV‐2, individually. major mode H‐bonding majorly participation dynamic spot catalytic residue HIS‐41 CYS‐145. Coniferyl has maximum energy −10.11 −11.23 complexation along proteases (6lu7 6w63). stronger COVID‐19 inhibitor, which ought investigated as potential target this virus.

Language: Английский

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Coronavirus Disease 2019 (COVID-19): A literature review

Jurnal Sains dan Kesehatan, Journal Year: 2020, Volume and Issue: 2(4), P. 548 - 557

Published: Dec. 31, 2020

Kasus pertama COVID-19 dilaporkan pada Desember 2019 ketika sekelompok pasien dirawat di rumah sakit Wuhan, ibukota provinsi Hubei Cina, yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Awalnya, berjangkitnya SARS CoV-2 hanya terbatas Hubei, tetapi menyebar dengan cepat ke banyak negara lain, dan Organisasi Kesehatan Dunia secara resmi mendeklarasikan pandemi global 11 Maret 2020. Secara umum, coronavirus menyebabkan penyakit sistem pernapasan, pencernaan, saraf pusat meluas manusia hewan mengancam kesehatan kerugian ekonomi. Masih kontroversi seputar ini, termasuk tata laksana hingga pencegahan. Oleh karena itu, saya melakukan telaah terhadap studi-studi terkait COVID-19. Dalam ulasan literatur penyebab, patogenesis respon imun, epidemiologi, diagnosis, perawatan manajemen strategi penyakit, kontrol pencegahan semuanya ditinjau.

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Novel corona virus (COVID-19); Global efforts and effective investigational medicines: A review

Journal of Infection and Public Health, Journal Year: 2021, Volume and Issue: 14(7), P. 910 - 921

Published: May 1, 2021

Coronavirus disease-2019 (COVID-19), associated with the outbreak of deadly virus originating in Wuhan, China, is now a global health emergency and matter serious concern. Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) rapidly spreading worldwide, WHO declared this disease pandemic on March 11, 2020. Though some countries have succeeded slowing down rate spread pandemic, most across globe are still continuing to experience an increasing trend growth disease. Hence, current scenario, has become essential control finally irradicate using effective vaccine. One can expect prominent role already available antivirals, antibodies anti-inflammatory drugs market, pandemic. Immunomodulatory biological therapeutics also high expectations combat COVID-19. RNA based vaccines might be more advantageous over traditional vaccines, deal threat. Aiming towards direction, clinical trials for SARS-CoV-2 vaccine currently underway all globe. Currently, about 150 related organizations research labs progress evolution COVID-19 globally. The initial aim these assess vaccine's safety, which tested Phase I/II/III studies where primary outcomes typically examine frequency adverse effects. undergo phase III testing several such as India, USA, South Africa, Brazil England. US Government, under Operation Wrap Speed even ready sponsor three candidates, namely-The University Oxford AstraZeneca's AZD1222; Moderna's mRNA-1273; Pfizer BioNTech's BNT162 trials.

Language: Английский

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Nanotechnology based solutions to combat zoonotic viruses with special attention to SARS, MERS, and COVID 19: Detection, protection and medication

Microbial Pathogenesis, Journal Year: 2021, Volume and Issue: 159, P. 105133 - 105133

Published: Aug. 12, 2021

Language: Английский

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Leveraging knowledge of Asian herbal medicine and its active compounds as COVID-19 treatment and prevention

Journal of Natural Medicines, Journal Year: 2021, Volume and Issue: 76(1), P. 20 - 37

Published: Oct. 8, 2021

Language: Английский

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