Ozone Treatment for the Management of Caries in Primary Dentition: A Systematic Review of Clinical Studies

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(3), P. 69 - 69

Published: March 6, 2024

Dental caries in children is a frequent and debilitating condition, whose management often challenging. The aim of this systematic review was to investigate the effectiveness ozone applications for treatment primary dentition. According PRISMA guidelines, literature search performed up 6 January 2024. Clinical studies using treat deciduous teeth were considered inclusion. Out 215 records retrieved, seven eventually included review, all which used gaseous ozone. Four judged at high risk bias, two low risk, one some concerns. great heterogeneity designs, outcomes, protocols made it impossible conduct meta-analysis. Despite limitations, evidence yielded by suggests that application, regardless protocol applied, comparable other interventions terms clinical outcomes anti-bacterial activity, with no reported adverse effects good patient acceptance. Therefore, application may be non-invasive approach dentition, especially very young poorly cooperative patients. Further standardized rigorous are, however, needed identify best specific field.

Language: Английский

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Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Biomedical Reports, Journal Year: 2024, Volume and Issue: 21(2)

Published: June 12, 2024

At low medically-relevant concentrations, ozone serves as an oxidant with a wide spectrum of antimicrobial activity and the ability to promote healing reduce inflammation. Despite providing therapeutic benefits in range diseases, certain adverse effects contraindications treatment must be considered. These are primarily related toxicity from inhalation systemic types administration can avoided by following relevant guidelines recommendations. Ozone therapy has been implemented number fields dentistry most commonly used formulations for oral cavity gaseous ozone, ozonized water oil. The biological mechanisms underlying molecular have increasingly reported, but currently remain largely unknown. aim present review was provide overview involved interaction dental tissues. focused on evidence regarding effect tissues, including periodontal structures, cells, enamel dentine, considering

Language: Английский

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Ozone–Oxygen Therapy to Prevent HPV-Related Cancers of the Lower Gynecological Tract in Infected Patients: The Rationale for Further Developments

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 543 - 543

Published: Feb. 6, 2025

Background: O3-O2 therapy is an alternative medical treatment that introduces a mixture of into the body for therapeutic purposes. The objective this study to evaluate its margins applicability in eradication HPV infection from lower gynecological tract by means vaginal insufflation. Methods: An in-depth review international literature on topic carried out; addition, compared with other treatments currently available terms advantages, disadvantages, and exploited technologies. Results: possible benefits limitations insufflation are explained detail; overall, it appears be interesting tool as part complex management prevent HPV-related cancers infected patients. Conclusions: rationale guidelines innovative procedure have been successfully illustrated, providing technical specifications further developments.

Language: Английский

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Benefits of melatonin on mortality in severe-to-critical COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials

Clinics, Journal Year: 2025, Volume and Issue: 80, P. 100638 - 100638

Published: Jan. 1, 2025

Language: Английский

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Mesenchymal Stem Cells on Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(4), P. 931 - 937

Published: March 1, 2024

Language: Английский

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Long‐term safety of macitentan in patients with pulmonary hypertension: A meta‐analysis of randomised controlled trials

European Journal of Clinical Investigation, Journal Year: 2023, Volume and Issue: 53(11)

Published: July 1, 2023

Abstract Background Macitentan has demonstrated its effectiveness in patients with pulmonary hypertension (PH), but safety, especially for long‐term use, needs to be further explored. This systematic review and meta‐analysis aimed determine the safety of use macitentan PH. Methods A search was made PubMed, Embase, Cochrane Library clinicaltrials.gov , without language restrictions. Randomised controlled trials (RCTs) on treatment PH macitentan, compared placebo, were reviewed. Estimated effects included studies pooled as risk ratios (RRs), 95% confidence intervals (CIs). Results Six RCTs (enrolling 1003 participants) met inclusion criteria. Anaemia (RR 3.86, CI 2.05–7.30), headache 1.52, 1.02–2.26) bronchitis 2.24, 1.30–3.87) more frequent groups. There no statistically significant difference proportion at least one adverse event (AE) or serious (SAE), AEs leading discontinuation study treatment, all‐cause death, right ventricular failure (RVF) peripheral oedema between two Conclusions The is safe PH, although a higher anaemia, bronchitis.

Language: Английский

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Benefits of Macitentan in Patients with Pulmonary Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Global Heart, Journal Year: 2023, Volume and Issue: 18(1), P. 58 - 58

Published: Oct. 26, 2023

Background: This systematic review and meta-analysis aimed to determine the efficacy of macitentan in patients with pulmonary hypertension (PH). Methods: A search was made PubMed, Embase, Cochrane Library, clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on treatment PH macitentan, compared placebo or blank, were reviewed. Studies pooled weighted mean differences (WMDs) risk ratios (RRs), 95% confidence intervals (CIs). Results: Six RCTs (enrolling 1,003 participants) met inclusion criteria. Macitentan showed significant effects 6-min walk distance (6MWD) (WMD 12.06 m, CI 2.12 21.99 m), vascular resistance (PVR) –186.51 dyn·s/cm–5, –232.72 –140.29 dyn·s/cm–5), artery pressure (mPAP) –3.20 mmHg, –5.93 –0.47 mmHg), N-terminal pro-brain natriuretic peptide (NT-proBNP) –232.47 ng/L, wCI –318.22 –146.72 ng/L), cardiac index 0.39 L/min/m2, 0.20 0.58 L/min/m2). Conclusion: significantly improved 6MWD, PVR, mPAP, NT-proBNP, PH. should be further validated

Language: Английский

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Inhaled corticosteroids on mortality in COVID-19: A systematic review and meta-analysis of randomized controlled trials

Journal of Investigative Medicine, Journal Year: 2024, Volume and Issue: 72(6), P. 567 - 573

Published: May 15, 2024

This systematic review and meta-analysis aimed to determine the efficacy of inhaled corticosteroids (ICS) on mortality in patients with coronavirus disease-2019 (COVID-19). A search was made PubMed, Embase, Cochrane Library, clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) treatment COVID-19 ICS were reviewed. Studies pooled risk ratios (RRs), 95% confidence intervals (CIs). Eleven RCTs (enrolling 5832 participants) met inclusion criteria. There no statistically significant difference COVID-19-related death (RR 0.88, CI 0.38–2.04), all-cause 1.05, 0.49–2.23), invasive ventilation 1.26, 0.60–2.62) between two groups. not associated reduced COVID-19.

Language: Английский

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Retrospective Evaluation of People Who Applied to a Traditional and Complementary Medicine Center

Journal of Traditional Medical Complementary Therapies, Journal Year: 2023, Volume and Issue: 6(3), P. 246 - 251

Published: Jan. 1, 2023

Amaç: Geleneksel ve tamamlayıcı tıp (GETAT) ülkemizde klinik akademik misyonuyla varlığını devam ettirmektedir. Bu çalışmada, hastanemizde bulunan GETAT uygulama merkezine başvuran kişilerin işlem verilerinin geriye dönük incelenmesi amaçlanmıştır. Gereç Yöntemler: kesitsel çalışmada bir merkezinin 2 yıllık hasta verileri taranmıştır. Hasta verilerine hastanenin otomasyon sistemi aracılığı ile ulaşılmıştır. İstatistikler SPSS 20,0 paket programı kullanılarak değerlendirilmiş olup 0,05'in altındaki p değerleri anlamlı kabul edilmiştir. Bulgular: Toplam 2.774 değerlendirmesi yapılmış olup, yaş ortancası 50,0 kadın sayısı 1.900 (%68,5), seans 1,0'dır. En sık kaydı yapılan mevsim kıştır (n=784, %28,3). İşlemler içerisinde ise en uygulanan ozon terapisidir (n=856, %49,9). başına tekrar edilen de (medyan: 10). Yapılan işlemler cinsiyet açısından değerlendirildiğinde aradaki fark anlam teşkil etmektedir (p<0,001). işlemleri hastaların başvuru sebebi ağrıdır (n=1.886, %68,0). Seanslar bitiğinde kullanılmış olan toplam sülük ortalaması 20,4±1,5'tir. Akupunktur seansların 242'si (%51,2) kulak, 54'ü (%11,4) vücut, 177'si (%37,4) kulak+vücut uygulamasıdır. Maggot terapi seanslarının 46'sı (%85,2) ayağa, 8?i (%14,8) diğer vücut bölgelerine uygulanmıştır. Sonuç: merkezinde işlemlerinin daha gerçekleştirildiği, ağrı şikâyeti başvuranların ağırlıkta olduğu görülmüştür. Cinsiyet mevsimin uygulamalarda etkili

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