Spatial navigation signals in rodent visual cortex DOI Creative Commons
Tom Floßmann, Nathalie L. Rochefort

Current Opinion in Neurobiology, Journal Year: 2020, Volume and Issue: 67, P. 163 - 173

Published: Dec. 25, 2020

During navigation, animals integrate sensory information with body movements to guide actions. The impact of both navigational and movement-related signals on cortical visual processing remains largely unknown. We review recent studies in awake rodents that have revealed navigation-related the primary cortex (V1) including speed, distance travelled head-orienting movements. Both subcortical inputs convey self-motion related V1 neurons: for example, top-down from secondary motor retrosplenial cortices about head spatial expectations. Within V1, subtypes inhibitory neurons are critical integration signals. conclude potential functional roles gain control, error predictive coding.

Language: Английский

Spontaneous behaviors drive multidimensional, brainwide activity DOI Open Access
Carsen Stringer, Marius Pachitariu, Nicholas A. Steinmetz

et al.

Science, Journal Year: 2019, Volume and Issue: 364(6437)

Published: April 19, 2019

Neuron activity across the brain How is it that groups of neurons dispersed through interact to generate complex behaviors? Three papers in this issue present brain-scale studies neuronal and dynamics (see Perspective by Huk Hart). Allen et al. found thirsty mice, there widespread neural related stimuli elicit licking drinking. Individual encoded task-specific responses, but every area contained with different types response. Optogenetic stimulation thirst-sensing one reinstated drinking previously signaled thirst. Gründemann investigated mouse basal amygdala relation behavior during tasks. Two ensembles showed orthogonal exploratory nonexploratory behaviors, possibly reflecting levels anxiety experienced these areas. Stringer analyzed spontaneous firing, finding primary visual cortex both information motor facial movements. The variability responses mainly arousal reflects encoding latent behavioral states. Science , p. eaav3932 eaav8736 eaav7893 ; see also 236

Language: Английский

Citations

1396
Breathing matters DOI
Christopher A. Del Negro, Gregory D. Funk, Jack L. Feldman

et al.

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(6), P. 351 - 367

Published: May 8, 2018

Language: Английский

Citations

575
Movement-Related Signals in Sensory Areas: Roles in Natural Behavior DOI
Philip R. L. Parker,

Morgan A. Brown,

Matthew C. Smear

et al.

Trends in Neurosciences, Journal Year: 2020, Volume and Issue: 43(8), P. 581 - 595

Published: June 22, 2020

Language: Английский

Citations

150
Neural circuits of social behaviors: Innate yet flexible DOI Creative Commons

Dongyu Wei,

Vaishali Talwar,

Dayu Lin

et al.

Neuron, Journal Year: 2021, Volume and Issue: 109(10), P. 1600 - 1620

Published: March 11, 2021

Language: Английский

Citations

144
Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics DOI Creative Commons
Caleb Weinreb, Jonah E Pearl, Sherry Lin

et al.

Nature Methods, Journal Year: 2024, Volume and Issue: 21(7), P. 1329 - 1339

Published: July 1, 2024

Abstract Keypoint tracking algorithms can flexibly quantify animal movement from videos obtained in a wide variety of settings. However, it remains unclear how to parse continuous keypoint data into discrete actions. This challenge is particularly acute because are susceptible high-frequency jitter that clustering mistake for transitions between Here we present keypoint-MoSeq, machine learning-based platform identifying behavioral modules (‘syllables’) without human supervision. Keypoint-MoSeq uses generative model distinguish noise behavior, enabling identify syllables whose boundaries correspond natural sub-second discontinuities pose dynamics. outperforms commonly used alternative methods at these transitions, capturing correlations neural activity and behavior classifying either solitary or social behaviors accordance with annotations. also works multiple species generalizes beyond the syllable timescale, fast sniff-aligned movements mice spectrum oscillatory fruit flies. Keypoint-MoSeq, therefore, renders accessible modular structure through standard video recordings.

Language: Английский

Citations

44
Activation of glutamatergic neurons in the organum vasculosum of the lamina terminalis induces thirst-driven sniffing DOI Creative Commons
Wei He,

Luo Shi,

Z Y Yue

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115254 - 115254

Published: Feb. 1, 2025

Sniffing is a specialized respiratory behavior that enables rodents to localize and track objects in their environment. The organum vasculosum of the lamina terminalis (OVLT) critically involved regulation thirst water intake, yet its role controlling thirst-driven exploratory sniffing behaviors remains unclear. This study demonstrates hypertonic stimulation significantly increases activates OVLT glutamatergic (OVLTGlut) neurons. Photostimulation both OVLTGlut neurons axon terminals within paraventricular nucleus hypothalamus (PVN) induces robust sniffing. Furthermore, ablation PVN projecting preBötzinger complex not only reduces time induced by photostimulation but also prolongs drinking latency. These findings identify OVLTGlut-PVN-preBötzinger circuit as pivotal regulator sniffing, providing insights into neural mechanisms underlying behavior.

Language: Английский

Citations

2
Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds DOI Creative Commons
Patrick J. Drew,

Céline Matéo,

Kevin L. Turner

et al.

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 782 - 804

Published: Aug. 12, 2020

Language: Английский

Citations

133
Breathing is coupled with voluntary action and the cortical readiness potential DOI Creative Commons
Hyeong-Dong Park, Coline Barnoud,

Henri Trang

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Feb. 6, 2020

Abstract Voluntary action is a fundamental element of self-consciousness. The readiness potential (RP), slow drift neural activity preceding self-initiated movement, has been suggested to reflect processes underlying the preparation voluntary action; yet more than fifty years after its introduction, interpretation RP remains controversial. Based on previous research showing that internal bodily signals affect sensory processing and ongoing activity, we here investigated role interoceptive in RP. We report (1) participants initiate actions frequently during expiration, (2) this respiration-action coupling absent externally triggered actions, (3) amplitude modulated depending respiratory phase. Our findings demonstrate coupled with system further suggest associated fluctuations are driven by involuntary cyclic motor act breathing.

Language: Английский

Citations

110
Circuits in the Rodent Brainstem that Control Whisking in Concert with Other Orofacial Motor Actions DOI Creative Commons
Lauren E. McElvain, Beth Friedman,

Harvey J. Karten

et al.

Neuroscience, Journal Year: 2017, Volume and Issue: 368, P. 152 - 170

Published: Aug. 23, 2017

Language: Английский

Citations

89
Control of Orienting Movements and Locomotion by Projection-Defined Subsets of Brainstem V2a Neurons DOI Creative Commons
Giovanni Usseglio,

Edwin Gatier,

Aurélie Heuzé

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(23), P. 4665 - 4681.e6

Published: Oct. 1, 2020

Spatial orientation requires the execution of lateralized movements and a change in animal's heading response to multiple sensory modalities. While much research has focused on circuits for integration, chiefly midbrain superior colliculus (SC), downstream cells that engage adequate motor actions have remained elusive. Furthermore, mechanisms supporting trajectory changes are still speculative. Here, using transneuronal viral tracings mice, we show brainstem V2a neurons, genetically defined subtype glutamatergic neurons reticular formation, receive putative synaptic inputs from contralateral SC. This makes them candidate relay orienting commands. We next unilateral optogenetic activations vivo evoked ipsilateral orienting-like responses head nose tip stationary mice. When animals walking, similar stimulations impose transient locomotor arrest followed by trajectory. Third, reveal these distinct controlled dedicated subsets each projecting specific spinal cord segment, with at least (1) lumbar-projecting subset whose activation specifically controls speed but neither impacts nor evokes movements, (2) cervical-projecting orientation, not speed. Activating latter suffices steer animals' directional heading, placing as prime driver their modular organization may therefore underlie orchestration during multi-faceted behaviors.

Language: Английский

Citations

72