New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress DOI Creative Commons
Jing Ouyang, Yuxuan Peng, Yushun Gong

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(23), P. 3930 - 3930

Published: Dec. 5, 2022

Sleep, a conservative evolutionary behavior of organisms to adapt changes in the external environment, is divided into natural sleep, healthy state, and sickness which occurs stressful environments or during illness. Sickness sleep plays an important role maintaining energy homeostasis under injury promoting physical recovery. Tea, popular phytochemical-rich beverage, has multiple health benefits, including lowering stress regulating metabolism sleep. However, tea received little attention. The mechanism underlying regulation its association with maintenance injured remains be elucidated. This review examines current research on effect regulation, focusing function modulating through metabolism, damage repair model organisms. potential mechanisms are further suggested. Based biohomology this provides novel insights new perspective restoring from diseases.

Language: Английский

What Is REM Sleep? DOI Creative Commons
Mark S. Blumberg, John A. Lesku, Paul‐Antoine Libourel

et al.

Current Biology, Journal Year: 2020, Volume and Issue: 30(1), P. R38 - R49

Published: Jan. 1, 2020

Language: Английский

Citations

124
Sleep and thermoregulation DOI Creative Commons
Edward C. Harding, Nicholas P. Franks, William Wisden

et al.

Current Opinion in Physiology, Journal Year: 2019, Volume and Issue: 15, P. 7 - 13

Published: Nov. 26, 2019

In homeothermic animals sleep preparatory behaviours often promote thermal efficiency, including warmth-seeking, adopting particular postures (curling up, head tucking) and nest building, all promoting warmer skin microclimates. Skin warmth induces NREM body cooling via circuitry that connects sensation to the preoptic hypothalamus. Coupling induction lower temperature could serve minimise energy expenditure or allow reallocation. Cooling during may also induce transcriptional changes in genes whose products facilitate housekeeping functions measure time spent sleeping.

Language: Английский

Citations

79
Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure DOI Creative Commons
Hui Feng,

Qi‐Cheng Qiao,

Qi-Fa Luo

et al.

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Proper timing of vigilance states serves fundamental brain functions. Although disturbance sleep onset rapid eye movement (SOREM) is frequently reported after orexin deficiency, their causal relationship still remains elusive. Here, we further study a specific subgroup neurons with convergent projection to the REM promoting sublaterodorsal tegmental nucleus (OX SLD neurons). Intriguingly, although OX and other projection-labeled exhibit similar activity dynamics during sleep, only activation level exhibits significant positive correlation post-inter-REM interval duration, revealing an essential role for orexin-sublaterodorsal (SLD) neural pathway in relieving pressure. Monosynaptic tracing reveals that multiple inputs may help shape this sleep-related neurons. Genetic ablation shows homeostatic architecture sleep/wakefulness cycles, especially avoidance SOREM sleep-like transition, dependent on activity. A between occurrence probability depression narcoleptic patients demonstrates possible significance orexin-SLD homeostasis.

Language: Английский

Citations

13
Sleep in Drosophila and Its Context DOI Creative Commons
Esteban J. Beckwith, Alice S. French

Frontiers in Physiology, Journal Year: 2019, Volume and Issue: 10

Published: Sept. 11, 2019

A prominent idea emerging from the study of sleep is that this key behavioural state regulated in a complex fashion by ecologically and physiologically relevant environmental factors. This concept implies sleep, as behaviour, plastic can be external agents changes internal state. Drosophila melanogaster constitutes resourceful model system to behaviour. In year 2000, utility fly was realised, has since extensively contributed exciting field. At centre review, we will discuss studies showing temperature, food availability/quality interactions with conspecifics regulate sleep. Indeed relationship reciprocal perturbation also affect feeding social interaction. particular, different temperatures well gradual temperature when, how much flies Moreover, satiation/starvation status an individual dictates balance between foraging. Nutritional composition diet direct impact on amount its fragmentation. Likewise, aggression males, courtship, sexual arousal, mating within large groups animals acute long-lasting effect quality. Importantly, genes neuronal circuits relay information about environment centres are starting elucidated focus review. conclusion, most behaviours, needs full commitment individual, preventing participation other vital activities. vast array behaviours modulated factors, compete need thus have significant role regulating it.

Language: Английский

Citations

71
Neural and Homeostatic Regulation of REM Sleep DOI
Sungho Park, Franz Weber

Frontiers in Psychology, Journal Year: 2020, Volume and Issue: 11

Published: July 21, 2020

Rapid eye movement (REM) sleep is a distinct, homeostatically controlled brain state characterized by an activated electroencephalogram (EEG) in combination with paralysis of skeletal muscles and associated vivid dreaming. Understanding how REM requires identification the neural circuits underlying its initiation maintenance, delineation homeostatic processes regulating expression on multiple timescales. Soon after discovery humans 1953, pons was demonstrated to be necessary sufficient for generation sleep. But, especially within last decade, researchers have identified further populations hypothalamus, midbrain, medulla that regulate either promoting or suppressing this state. The these greatly facilitated availability novel technologies dissection circuits. Recent quantitative models integrate findings about activity connectivity key neurons knowledge mechanisms explain dynamics recurrence For future, combining experimental approaches directly test model predictions refine existing will advance our understanding governing regulation

Language: Английский

Citations

65
MCH Neurons Regulate Permeability of the Median Eminence Barrier DOI Creative Commons
Hong Jiang, Sarah Gallet, Paul Klemm

et al.

Neuron, Journal Year: 2020, Volume and Issue: 107(2), P. 306 - 319.e9

Published: May 13, 2020

Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity tanycytes fenestrated vessels. Chemogenetic activation MCH as well optogenetic stimulation their ME enhance permeability by increasing vascular loops leptin action arcuate nucleus hypothalamus (ARC). Unbiased phosphoRiboTrap-based assessment cell upon chemogenetic neuron reveals MCH-neuron-dependent regulation endothelial cells. express growth factor A (VEGFA), blocking VEGF-R signaling attenuates leptin-sensitizing effect activation. Our experiments reveal directly regulate barrier, linking activity state sleep regulatory accessibility ARC.

Language: Английский

Citations

60
Which structure generates paradoxical (REM) sleep: The brainstem, the hypothalamus, the amygdala or the cortex? DOI Creative Commons
Pierre‐Hervé Luppi, Amarine Chancel,

Justin Malcey

et al.

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 74, P. 101907 - 101907

Published: Jan. 29, 2024

Paradoxical or Rapid eye movement (REM) sleep (PS) is a state characterized by REMs, EEG activation and muscle atonia. In this review, we discuss the contribution of brainstem, hypothalamic, amygdalar cortical structures in PS genesis. We propose that atonia during due to glutamatergic neurons localized pontine sublaterodorsal tegmental nucleus (SLD) projecting glycinergic/GABAergic pre-motoneurons ventro-medial medulla (vmM). The SLD PS-on are inactivated wakefulness slow-wave PS-off GABAergic ventrolateral periaqueductal gray (vPAG) adjacent deep mesencephalic reticular nucleus. Melanin concentrating hormone (MCH) posterior hypothalamus would inhibit these initiate state. Finally, few limbic claustrum supramammillary as well basolateral amygdala also contribute expression. Accumulating evidence indicates plays role memory consolidation communicate PS-generating need for process memory. summary, generation controlled distributed from cortex medullary level brain.

Language: Английский

Citations

6
Energetic costs and benefits of sleep DOI Creative Commons
John A. Lesku, Markus H. Schmidt

Current Biology, Journal Year: 2022, Volume and Issue: 32(12), P. R656 - R661

Published: June 1, 2022

Language: Английский

Citations

21
Hypothalamic MCH Neurons: From Feeding to Cognitive Control DOI Creative Commons
Cristina Concetti, Daria Peleg‐Raibstein, Denis Burdakov

et al.

Function, Journal Year: 2023, Volume and Issue: 5(1)

Published: Oct. 27, 2023

Abstract Modern neuroscience is progressively elucidating that the classic view positing distinct brain regions responsible for survival, emotion, and cognitive functions outdated. The hypothalamus demonstrates interdependence of these roles, as it traditionally known fundamental survival like energy electrolyte balance, but now recognized to also play a crucial role in emotional processes. This review focuses on lateral hypothalamic melanin-concentrating hormone (MCH) neurons, producing neuropeptide MCH—a relatively understudied neuronal population with integrative related homeostatic regulation motivated behaviors, widespread inputs outputs throughout entire central nervous system. Here, we early findings recent literature outlining their sleep, learning, memory

Language: Английский

Citations

12
Neurobiology and Neuroprotective Benefits of Sleep DOI
Logan Schneider

CONTINUUM Lifelong Learning in Neurology, Journal Year: 2020, Volume and Issue: 26(4), P. 848 - 870

Published: July 30, 2020

This article outlines the neurocircuitry underlying sleep-wake and circadian physiology with a focus on fundamental roles that sleep health play in optimal neurologic function.The foundation of wake promotion is laid primarily by "fast-acting" neurotransmitters: γ-aminobutyric acid (GABA) for glutamate wake. External to these primary systems are host modulatory characterized two flip-flop switches mutually inhibitory neurotransmitter facilitate transitions between as well non-rapid eye movement (non-REM) REM sleep. Additional mechanisms place help coordinate states environmental, metabolic, behavioral demands. The complexity evolutionarily preserved systems, proportion day dedicated natural sleeping period, neurocognitive dysfunction neurodegeneration caused deficient highlight importance defining, assessing, optimizing our patients ourselves.Exciting discoveries continue elucidate state coordination, reinforcing healthy practices paving way new interventions preserve promote health.

Language: Английский

Citations

30