Experience
influences
behavior,
but
little
is
known
about
how
experience
encoded
in
the
brain,
and
changes
neural
activity
are
implemented
at
a
network
level
to
improve
performance.
Here
we
investigate
differences
impact
brain
circuitry
behavior
larval
zebrafish
prey
capture.
We
find
that
of
live
compared
inert
food
increases
capture
success
by
boosting
initiation.
In
response
prey,
animals
with
without
prior
show
visual
areas
(pretectum
optic
tectum)
motor
(cerebellum
hindbrain),
similar
area
retinotopic
maps
position.
However,
prey-experienced
more
readily
initiate
have
greater
visually-evoked
two
forebrain
areas:
telencephalon
habenula.
Consequently,
disruption
habenular
neurons
reduces
performance
fish.
Together,
our
results
suggest
strengthens
prey-associated
drive
forebrain,
this
lowers
threshold
for
trigger
areas,
thereby
improving
Current Biology,
Journal Year:
2021,
Volume and Issue:
31(11), P. R741 - R762
Published: June 1, 2021
The
superior
colliculus,
or
tectum
in
the
case
of
non-mammalian
vertebrates,
is
a
part
brain
that
registers
events
surrounding
space,
often
through
vision
and
hearing,
but
also
electrosensation,
infrared
detection,
other
sensory
modalities
diverse
vertebrate
lineages.
This
information
used
to
form
maps
space
positions
different
salient
stimuli
relation
individual.
are
arranged
layers
with
visual
input
uppermost
layer,
senses
deeper
positions,
spatially
aligned
motor
map
deepest
layer.
Here,
we
will
review
organization
intrinsic
function
tectum/superior
colliculus
processed
within
tectal
circuits.
We
discuss
tectal/superior
outputs
conveyed
directly
downstream
circuits
via
thalamus
cortical
areas
control
various
aspects
behavior.
evolutionarily
conserved
among
all
tailored
specialties
each
lineage,
its
roles
have
shifted
emergence
cerebral
cortex
mammals.
illustrate
both
divergent
properties
evolution
by
comparing
processing
lampreys
belonging
oldest
group
extant
larval
zebrafish,
rodents,
vertebrates
including
primates.
Neuron,
Journal Year:
2020,
Volume and Issue:
107(2), P. 320 - 337.e6
Published: May 29, 2020
In
the
eye,
function
of
same-type
photoreceptors
must
be
regionally
adjusted
to
process
a
highly
asymmetrical
natural
visual
world.
Here,
we
show
that
UV
cones
in
larval
zebrafish
area
temporalis
are
specifically
tuned
for
UV-bright
prey
capture
their
upper
frontal
field,
which
may
use
signal
from
single
cone
at
time.
For
this,
UV-photon
detection
probability
is
boosted
more
than
10-fold.
Next,
vivo
two-photon
imaging,
transcriptomics,
and
computational
modeling
reveal
these
an
elevated
baseline
synaptic
calcium
facilitate
encoding
bright
objects,
turn
results
expressional
tuning
phototransduction
genes.
Moreover,
light-driven
slowed
by
interactions
with
horizontal
cells
later
accentuated
level
glutamate
release
driving
retinal
networks.
These
regional
differences
tally
variations
between
peripheral
foveal
primates
hint
common
mechanistic
origin.
Science,
Journal Year:
2024,
Volume and Issue:
383(6685), P. 890 - 897
Published: Feb. 22, 2024
Recordings
of
the
physiological
history
cells
provide
insights
into
biological
processes,
yet
obtaining
such
recordings
is
a
challenge.
To
address
this,
we
introduce
method
to
record
transient
cellular
events
for
later
analysis.
We
designed
proteins
that
become
labeled
in
presence
both
specific
activity
and
fluorescent
substrate.
The
recording
period
set
by
substrate,
whereas
controls
degree
labeling.
use
distinguishable
substrates
enabled
successive
periods
activity.
recorded
protein-protein
interactions,
G
protein-coupled
receptor
activation,
increases
intracellular
calcium.
elevated
calcium
levels
allowed
selections
from
heterogeneous
populations
transcriptomic
analysis
tracking
neuronal
activities
flies
zebrafish.
Current Biology,
Journal Year:
2020,
Volume and Issue:
30(14), P. 2665 - 2680.e8
Published: May 28, 2020
Cognition
arises
from
the
dynamic
flow
of
neural
activity
through
brain.
To
capture
these
dynamics,
we
used
mesoscale
calcium
imaging
to
record
across
dorsal
cortex
awake
mice.
We
found
that
large
majority
variance
in
cortex-wide
(∼75%)
could
be
explained
by
a
limited
set
∼14
"motifs"
activity.
Each
motif
captured
unique
spatiotemporal
pattern
cortex.
These
motifs
generalized
animals
and
were
seen
multiple
behavioral
environments.
Motif
expression
differed
states,
specific
engaged
sensory
processing,
suggesting
reflect
core
cortical
computations.
Together,
our
results
show
is
highly
but
dynamics
are
restricted
low-dimensional
motifs,
potentially
allowing
for
efficient
control
behavior.
