Why is everyone talking about brain state?

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 46(7), P. 508 - 524

Published: May 8, 2023

The rapid and coordinated propagation of neural activity across the brain provides foundation for complex behavior cognition. Technical advances neuroscience subfields have advanced understanding these dynamics, but points convergence are often obscured by semantic differences, creating silos subfield-specific findings. In this review we describe how a parsimonious conceptualization state as fundamental building block whole-brain offers common framework to relate findings scales species. We present examples diverse techniques commonly used study states associated with physiology higher-order cognitive processes, discuss integration them will enable more comprehensive mechanistic characterization dynamics that crucial survival disrupted in disease.

Language: Английский

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Beta: bursts of cognition

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(7), P. 662 - 676

Published: April 23, 2024

Beta oscillations are linked to the control of goal-directed processing sensory information and timing motor output. Recent evidence demonstrates they not sustained but organized into intermittent high-power bursts mediating timely functional inhibition. This implies there is a considerable moment-to-moment variation in neural dynamics supporting cognition. thus offer new opportunities for studying how inputs selectively processed, reshaped by inhibitory cognitive operations ultimately result actions. method advances reveal diversity beta that provide deeper insights their function underlying circuit activity motifs. We propose brain-wide, spatiotemporal patterns bursting reflect various nonlinear aspects cortical processing.

Language: Английский

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Simultaneous, cortex-wide dynamics of up to 1 million neurons reveal unbounded scaling of dimensionality with neuron number

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1694 - 1709.e5

Published: March 6, 2024

Language: Английский

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Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics

Neuron, Journal Year: 2020, Volume and Issue: 108(1), P. 33 - 43

Published: Oct. 1, 2020

Language: Английский

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Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response

Neuron, Journal Year: 2021, Volume and Issue: 109(13), P. 2183 - 2201.e9

Published: June 1, 2021

The neuronal mechanisms generating a delayed motor response initiated by sensory cue remain elusive. Here, we tracked the precise sequence of cortical activity in mice transforming brief whisker stimulus into licking using wide-field calcium imaging, multiregion high-density electrophysiology, and time-resolved optogenetic manipulation. Rapid evoked deflection acquired two prominent features for task performance: (1) an enhanced excitation secondary cortex, suggesting its important role connecting processing to lick planning; (2) transient reduction orofacial sensorimotor which contributed suppressing premature licking. Subsequent widespread during delay period largely correlated with anticipatory movements, but when these were accounted for, focal sustained remained frontal was causally essential period. Our results demonstrate key nodes plan generation timely execution goal-directed

Language: Английский

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Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion

Cerebral Cortex, Journal Year: 2021, Volume and Issue: 32(12), P. 2668 - 2687

Published: Sept. 15, 2021

Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex's role requires a mesoscopic-level description regions engaged, their functional interactions, how these interactions change with behavioral state. Mesoscopic Ca2+ imaging through transparent polymer skulls mice reveals elevated activation dorsal cortex during locomotion. Using correlations between time series fluorescence from 28 (nodes) obtained using spatial independent component analysis (sICA), we examined changes connectivity rest to locomotion goal state that facilitate Both transitions show marked increases correlation among most nodes. However, once steady continued is reached, many nodes, including primary somatosensory decreases correlations, while retrosplenial anterior nodes secondary increases. These highlight cortex, representing on return rest.

Language: Английский

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Not so spontaneous: Multi-dimensional representations of behaviors and context in sensory areas

Neuron, Journal Year: 2022, Volume and Issue: 110(19), P. 3064 - 3075

Published: July 20, 2022

Sensory areas are spontaneously active in the absence of sensory stimuli. This spontaneous activity has long been studied; however, its functional role remains largely unknown. Recent advances technology, allowing large-scale neural recordings awake and behaving animal, have transformed our understanding activity. Studies using these discovered high-dimensional patterns, correlation between behavior, dissimilarity sensory-driven patterns. These findings supported by evidence from developing animals, where a transition toward characteristics is observed as circuit matures, well mature animals across species. newly revealed call for formulation new computation.

Language: Английский

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Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

Nature Neuroscience, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 23, 2023

Abstract Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) have been observed within areas, but it is not known whether these local extend throughout cortex, nor additional emerge when larger-scale dynamics are considered. We used genetic and retrograde labeling to target tract, intratelencephalic corticostriatal projection neurons measured their cortex-wide activity. Each PyN type drove unique neural dynamics, both at scales. Cortical activity optogenetic inactivation during an auditory decision task revealed distinct functional roles. All PyNs in parietal cortex were recruited perception of stimulus, but, surprisingly, tract had largest causal role. In frontal all required for accurate choices showed choice tuning. Our results reveal rich, cell-type-specific shape perceptual decisions.

Language: Английский

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Working memory control dynamics follow principles of spatial computing

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 14, 2023

Working memory (WM) allows us to remember and selectively control a limited set of items. Neural evidence suggests it is achieved by interactions between bursts beta gamma oscillations. However, not clear how oscillations, reflecting coherent activity millions neurons, can individual WM Here we propose the novel concept spatial computing where cause item-specific flow spatially across network during task. This way, control-related information such as item order stored in independent detailed recurrent connectivity supporting itself. The turn reflected low-dimensional shared many neurons. We verify these predictions analyzing local field potentials neuronal spiking. hypothesize that facilitate generalization zero-shot learning utilizing component an additional encoding dimension.

Language: Английский

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Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 27(1), P. 148 - 158

Published: Nov. 30, 2023

Language: Английский

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