The chemosensory system of the Drosophila larva: an overview of current understanding DOI Creative Commons
Nikita Komarov, Simon G. Sprecher

Fly, Journal Year: 2021, Volume and Issue: 16(1), P. 1 - 12

Published: Oct. 6, 2021

Animals must sense their surroundings and be able to distinguish between relevant irrelevant cues. An enticing area of research aims uncover the mechanisms by which animals respond chemical signals that constitute critical sensory input. In this review, we describe principles a model chemosensory system: Drosophila larva. While distinct in many ways, larval behaviour is reminiscent dogmatic goals life: reach stage reproductive potential. It takes into account number identifiable parameters ultimately provoke or modulate appropriate behavioural output. light, current knowledge anatomy, genetic components, processing logic We outline recent advancements summarize hypothesized neural circuits systems. Furthermore, note yet-unanswered questions create basis for further investigation molecular systemic chemosensation beyond.

Language: Английский

Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions DOI Creative Commons
Dick R. Nässel, Meet Zandawala

Open Biology, Journal Year: 2022, Volume and Issue: 12(7)

Published: July 1, 2022

Plasticity in animal behaviour relies on the ability to integrate external and internal cues from changing environment hence modulate activity synaptic circuits of brain. This context-dependent neuromodulation is largely based non-synaptic signalling with neuropeptides. Here, we describe select peptidergic systems Drosophila brain that act at different levels a hierarchy associated physiology. These regions, such as central complex mushroom bodies, which supervise specific behaviours. At top level there are small numbers large neurons arborize widely multiple areas orchestrate or global state manner. bottom local provide executive sensory gain intrinsically restricted parts neuronal circuits. The orchestrating receive interoceptive signals mediate energy sleep homeostasis, metabolic circadian timing, well affect food search, aggression mating. Some these can be triggers conflicting behaviours mating versus aggression, feeding, participate circuits, enabling choices switches.

Language: Английский

Citations

56
Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila DOI Creative Commons
Anita V. Devineni, Kristin M. Scaplen

Frontiers in Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 6, 2022

Behavioral flexibility is critical to survival. Animals must adapt their behavioral responses based on changes in the environmental context, internal state, or experience. Studies Drosophila melanogaster have provided insight into neural circuit mechanisms underlying flexibility. Here we discuss how behavior modulated by and learning. We describe general principles of organization modulation that underlie flexibility, are likely extend other species.

Language: Английский

Citations

41
Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila DOI Creative Commons
Sebastian Hückesfeld, Philipp Schlegel, Anton Miroschnikow

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: June 2, 2021

Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides hormones that are released act target organs periphery, synaptic inputs onto these neuroendocrine outputs brain less well understood. Here, we use transmission electron microscopy reconstruction whole central nervous system Drosophila larva to elucidate sensory pathways interneurons provide input neurosecretory cells projecting endocrine organs. Predicted by network modeling, also identify new carbon dioxide-responsive acts specific set includes those expressing corazonin (Crz) diuretic hormone 44 (Dh44) neuropeptides. Our analysis reveals neuronal architecture for combinatorial action based interneuronal converge distinct combinations outputs.

Language: Английский

Citations

44
The neuronal logic of how internal states control food choice DOI
Daniel Münch, Dennis Goldschmidt, Carlos Ribeiro

et al.

Nature, Journal Year: 2022, Volume and Issue: 607(7920), P. 747 - 755

Published: July 6, 2022

Language: Английский

Citations

34
Exploring the role of gut microbiota in host feeding behavior among breeds in swine DOI Creative Commons
Yuqing He, Francesco Tiezzi, Jeremy Howard

et al.

BMC Microbiology, Journal Year: 2022, Volume and Issue: 22(1)

Published: Jan. 3, 2022

Abstract Background The interplay between the gut microbiota and feeding behavior has consequences for host metabolism health. present study aimed to explore overall influence on traits identify specific microbes associated with in three commercial swine breeds at growth stages. Feeding measures were obtained from 651 pigs of (Duroc, Landrace, Large White) an average 73 163 days age. Seven covered information feed intake, feeder occupation time, rate, number visits feeder. Rectal swabs collected each pig ± 3, 123 4, 158 4 DNA was extracted subjected 16 S rRNA gene sequencing. Results Differences among during period found. proportion phenotypic variances explained by microbial composition small moderate (ranged 0.09 0.31). A total 21, 10, 35 amplicon sequence variants found be significantly (q-value < 0.05) Duroc, White across sampling time points. identified annotated five phyla, Firmicutes being most abundant. Those assigned 28 genera, mainly including Christensenellaceae _R-7_group, Ruminococcaceae _UCG-004, Dorea, _UCG-014, Marvinbryantia . Conclusions This demonstrated importance interacting multiple archaea bacteria either or Our provides insight into interaction highlights genetic background age effects studies.

Language: Английский

Citations

29
Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila DOI Open Access
Jayati Gera, Marishia Agard,

Hannah Nave

et al.

Published: May 7, 2024

Insects have evolved a variety of neurohormones that enable them to maintain their nutrient and osmotic homeostasis. While the identities functions various insect metabolic diuretic hormones been well-established, characterization an anti-diuretic signaling system is conserved across most insects still lacking. To address this, here we characterized ion transport peptide (ITP) in Drosophila . The ITP gene encodes five transcript variants which generate three different isoforms: amidated (ITPa) two ITP-like (ITPL1 ITPL2) isoforms. Using combination anatomical mapping single-cell transcriptome analyses, comprehensively expression all isoforms nervous peripheral tissues. Our analyses reveal widespread Moreover, show ITPa released during dehydration recombinant inhibits peptide-induced renal tubule secretion ex vivo , thus confirming its role as hormone. phylogenetic-driven approach assay, identified functionally Gyc76C, membrane guanylate cyclase, elusive receptor. Thus, knockdown Gyc76C tubules abolishes inhibitory effect on hormone secretion. Extensive reveals it highly expressed larval adult tissues associated with osmoregulation (renal rectum) homeostasis (fat body). Consistent this expression, impacts tolerance ionic stresses, whereas specifically fat body feeding, behaviors. We also complement receptor experiments overexpression neurons. Interestingly, ITPa-Gyc76C pathways deciphered are reminiscent atrial natriuretic mammals. Lastly, utilized connectomics transcriptomics identify synaptic paracrine upstream downstream ITP-expressing Taken together, our systematic establishes tractable decipher how small set neurons integrates diverse inputs orchestrate systemic

Language: Английский

Citations

6
Serotonergic modulation of swallowing in a complete fly vagus nerve connectome DOI Creative Commons
Andreas Schoofs, Anton Miroschnikow, Philipp Schlegel

et al.

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

4
From sensory organs to internal pathways: A comprehensive review of amino acid sensing in Drosophila DOI
Yi Quan, Liangyao Xiong

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 111828 - 111828

Published: Feb. 1, 2025

Language: Английский

Citations

0
Inhibitory circuit motifs in Drosophila larvae generate motor program diversity and variability DOI Creative Commons

Jacob Francis,

Caius Gibeily, William V. Smith

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(4), P. e3003094 - e3003094

Published: April 21, 2025

How do neural networks generate and regulate diversity variability in motor outputs with finite cellular components? Here we examine this problem by exploring the role that inhibitory neuron motifs play generating mixtures of programs segmentally organised Drosophila larval locomotor system. We developed a computational model is constrained experimental calcium imaging data. The comprises single-compartment cells single voltage-gated current, which are interconnected graded excitatory synapses. Local neurons form conditional oscillators each hemisegment. Surrounding architecture reflects key aspects inter- intrasegmental connectivity identified literature. generates metachronal waves activity recapitulate features fictive forwards backwards locomotion, as well bilaterally asymmetric anterior regions represents head sweeps. statistics inputs to competing command-like motifs, coupled detect across multiple segments network states promote outputs, while at same time preventing maladaptive overlap programs. Overall, testable predictions for connectomics physiological studies providing platform uncovering how circuit underpin generation systems.

Language: Английский

Citations

0
Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction DOI Creative Commons
Di Guo, Yijie Zhang, Su Zhang

et al.

PLoS Genetics, Journal Year: 2021, Volume and Issue: 17(8), P. e1009724 - e1009724

Published: Aug. 16, 2021

Feeding is essential for animal survival and reproduction regulated by both internal states external stimuli. However, little known about how influence the perception of sensory cues that regulate feeding behavior. Here, we investigated neuronal molecular mechanisms behind nutritional state-mediated regulation gustatory in control behavior brown planthopper Drosophila. We found increases expression cholecystokinin-like peptide, sulfakinin (SK), activity a set SK-expressing neurons. Starvation elevates transcription sugar receptor Gr64f SK negatively regulates insects. Interestingly, one two receptors, CCKLR-17D3, expressed some Gr64f-expressing neurons proboscis proleg tarsi. Thus, have identified as neuropeptide signal circuitry responds to food intake, diminishing gene sweet sensing GRNs. Our findings demonstrate state-dependent pathway modulates thereby behavior, but our experiments cannot exclude further parallel pathways. Importantly, show underlying are conserved distantly related insect species.

Language: Английский

Citations

27