An open-source, high-performance tool for automated sleep staging

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Oct. 14, 2021

The clinical and societal measurement of human sleep has increased exponentially in recent years. However, unlike other fields medical analysis that have become highly automated, basic research still relies on visual scoring. Such human-based evaluations are time-consuming, tedious, can be prone to subjective bias. Here, we describe a novel algorithm trained validated +30,000 hr polysomnographic recordings across heterogeneous populations around the world. This tool offers high sleep-staging accuracy matches scoring interscorer agreement no matter population kind. software is designed especially easy use, computationally low-demanding, open source, free. Our hope this facilitates broad adoption an industry-standard automated staging package.

Language: Английский

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Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging

JAMA Neurology, Journal Year: 2021, Volume and Issue: 78(10), P. 1187 - 1187

Published: Aug. 30, 2021

Importance

Disrupted sleep is common in aging and associated with cognition. Age-related changes to are multiple causes, including early Alzheimer disease pathology (amyloid β [Aβ]), depression, cardiovascular disease.

Objective

To investigate the associations between self-reported duration brain Aβ burden as well demographic, cognitive, lifestyle variables adults normal

Design, Setting, Participants

This cross-sectional study obtained data from participants Anti-Amyloid Treatment Asymptomatic Alzheimer's Disease (A4) study, which being conducted 67 sites United States, Canada, Australia, Japan. The sample for this analysis consisted of individuals aged 65 85 years who underwent an positron emission tomography (PET) scan, had complete apolipoprotein E (APOE) genotype data, were identified clinically (per a Clinical Dementia Rating score 0) cognitively unimpaired Mini-Mental State Examination 25 30 Logical Memory Delayed Recall test 6 18). Data analyzed April 3, 2020, June 20, 2021.

Main Outcomes Measures

outcome was nightly (grouped by short duration: ≤6 hours, 7-8 long ≥9 hours) compared demographic characteristics, (as measured fluorine 18–labeled-florbetapir PET scan), objective subjective cognitive function measures, variables.

Results

4417 included 2618 women (59%) mean (SD) age 71.3 (4.7) years. Self-reported shorter linearly higher (β [SE] = –0.01 [0.00];P .005), reduced cognition that mostly memory domains. No difference found groups 0.00 [0.01];P .99). However, duration, both durations body mass index (short vs 0.48 [0.17],P .01; 0.97 [0.31],P .002), depressive symptoms 0.31 [0.05],P < .001; 0.39 [0.09],P .001), daytime napping 2.66 [0.77],P 3.62 [1.38],P .01). Long worse performance across

Conclusions Relevance

In outcomes older adults, such greater burden, symptoms, index, decline, emphasizing importance maintaining adequate sleep.

Language: Английский

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The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health

Nature Aging, Journal Year: 2022, Volume and Issue: 2(5), P. 425 - 437

Published: April 28, 2022

Language: Английский

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Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association

Stroke, Journal Year: 2024, Volume and Issue: 55(3)

Published: Jan. 18, 2024

Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease cognitive outcomes, including the development of Alzheimer disease-related dementias. Sleep disorders such as sleep-disordered breathing (eg, obstructive apnea), other disturbances, well, some which are also considered insomnia, fragmentation, circadian rhythm extreme duration), have been associated with health. Understanding causal role disturbances in health is complicated by common among individuals neurodegenerative disease. In addition injury, mechanistic hypotheses linking biomarker data (blood-based, cerebrospinal fluid-based, imaging) suggest direct links disease-specific pathology. These potential mechanisms increasing understanding "glymphatic system," recognition importance poststroke recovery, support biological basis for indirect (through worsening vascular disease) specific effects on neuropathology) connections Given promising benefits treatment prevention, represent targets early that may improve more broadly. this scientific statement, we discuss supporting an association poor dementia opportunities prevention treatment.

Language: Английский

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Associations of sleep disorders with all-cause MCI/dementia and different types of dementia – clinical evidence, potential pathomechanisms and treatment options: A narrative review

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 22, 2024

Due to worldwide demographic change, the number of older persons in population is increasing. Aging accompanied by changes sleep structure, deposition beta-amyloid (Aß) and tau proteins vascular can turn into mild cognitive impairment (MCI) as well dementia. Sleep disorders are discussed both a risk factor for consequence MCI/dementia. Cross-sectional longitudinal population-based case–control studies revealed disorders, especially sleep-disorderded breathing (SDB) excessive or insufficient durations, factors all-cause Regarding different dementia types, SDB was associated with while insomnia/insufficient related an increased Alzheimer’s disease (AD). Scarce still inconsistent evidence suggests that therapy continuous positive airway pressure (CPAP) SDB, improve cognition patients without comorbid delay onset MCI/dementia previous impairment. potential pathomechanisms via which lead MCI/dementia, disturbed sleep, chronic deficit impair glymphatic clearance amyloid aggregation resulting brain structures responsible cognition. Orexins modulate Aß pathology. Their diurnal fluctuation suppressed fragmentation expression at point hippocampal atrophy, contributing progression Additionally, profile such inflammation, endothelial dysfunction atherosclerosis foster neurodegenerative There ample indicating structure aging also disorder Therefore, should be identified treated early.

Language: Английский

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Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION Sleep disturbances are associated with Alzheimer's disease (AD) and related dementias (ADRD), but the relationship between sleep architecture, particularly rapid eye movement (REM) sleep, AD/ADRD biomarkers remains unclear. METHODS We enrolled 128 adults (64 disease, 41 mild cognitive impairment [MCI], 23 normal cognition [NC]), mean age 70.8 ± 9.6 years, 56.9% female, from a tertiary hospital in China. Participants underwent overnight polysomnography (PSG), amyloid β (Aβ) positron emission tomography (PET), plasma biomarker analysis: phosphorylated tau at threonine 181 (p‐tau181), neurofilament light (NfL), brain‐derived neurotrophic factor (BDNF). RESULTS After adjusting for demographics, apolipoprotein E ( APOE ) ε4 status, cognition, comorbidities, highest tertile of REM latency was higher Aβ burden = 0.08, 95% confidence interval [CI]: 0.03 to 0.13, p 0.002), elevated p‐tau181 0.19, CI: 0.02 reduced BDNF levels ‐0.47, –0.68 –0.13, 0.013), compared lowest tertile. DISCUSSION Prolonged may serve as novel marker or risk pathogenesis. Highlights Rapid (REML) be potential (AD/ADRD) REML beta burden, tau‐181 lower (BDNF) levels. Intervention trial is needed determine if targeting can modify risk. Slow‐wave not biomarkers.

Language: Английский

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The interconnected causes and consequences of sleep in the brain

Science, Journal Year: 2021, Volume and Issue: 374(6567), P. 564 - 568

Published: Oct. 28, 2021

Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term, lack sleep leads to impaired memory and attention; longer it produces neurological dysfunction or even death. I discuss recent advances understanding how maintains physiological health through interconnected systems neuronal activity fluid flow. The neural dynamics that appear during are intrinsically coupled its consequences blood flow, cerebrospinal dynamics, waste clearance. Recognizing these linked causes has shed new light on why important such disparate aspects function.

Language: Английский

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EEG alterations during wake and sleep in mild cognitive impairment and Alzheimer's disease

iScience, Journal Year: 2021, Volume and Issue: 24(4), P. 102386 - 102386

Published: April 1, 2021

Patients with Alzheimer's disease (AD) undergo a slowing of waking electroencephalographic (EEG) rhythms since prodromal stages, which could be ascribed to poor sleep quality. We examined the relationship between wake and alterations by assessing EEG activity during (pre-sleep/post-sleep) wakefulness in AD, mild cognitive impairment (MCI) healthy controls. AD MCI show high latency less slow-wave sleep. Reduced sigma characterizes non-rapid eye movement (NREM) sleep, reflecting spindles loss. The REM MCI, strong correlations among two phenomena suggesting common neuropathological mechanisms. Evening-to-morning variations revealed gradual disappearance overnight changes delta activity, indicating progressive decay restorative functions on diurnal that correlates high-frequency AD. Our findings support linkage alterations, importance sleep-related processes progression.

Language: Английский

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Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 272 - 284

Published: Feb. 19, 2024

Language: Английский

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Divergent Associations of Slow‐Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid‐Beta

Annals of Neurology, Journal Year: 2024, Volume and Issue: 96(1), P. 46 - 60

Published: April 16, 2024

Recent evidence shows that during slow-wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as amyloid-beta protein. Poor or elevated cortisol levels can worsen clearance, leading to formation of amyloid plaques, a neuropathological hallmark Alzheimer disease. Here, we explored how nocturnal neural and endocrine activity affects fluctuations in peripheral blood.

Language: Английский

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