Distinguishing neural correlates of prediction errors on perceptual content and detection of content DOI Open Access
Nadine Dijkstra, Oliver Warrington, Peter Kok

et al.

Published: Feb. 8, 2023

Accounting for why discrimination between different perceptual contents is not always accompanied by conscious detection of that content remains a challenge predictive processing theories perception. Here we test hypothesis supported distinct inference within generative models content. We develop novel visual perception paradigm probes such inferences manipulating both expectations about stimulus (stimulus identity) and presence). In line with model simulations show influence reaction times on categorisation task. By combining no-report version our task functional neuroimaging reveal violations are but interacting neural substrates: PEs tracked predominantly in posterior sensory cortex whereas prefrontal cortex. Together, results highlight distributed basis the human brain.

Language: Английский

An adversarial collaboration to critically evaluate theories of consciousness DOI Creative Commons
Oscar Ferrante, Urszula Górska, Simon Henin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Summary Different theories explain how subjective experience arises from brain activity 1,2 . These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field 3 Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT) 4,5 Global Neuronal Workspace (GNWT) 6–10 , employing a theory-neutral consortium approach 11,12 We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation 12 256 human subjects viewed suprathreshold stimuli for variable durations while was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.

Language: Английский

Citations

53
Thalamic contributions to the state and contents of consciousness DOI Creative Commons
Christopher J. Whyte, Michelle J. Redinbaugh, James M. Shine

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1611 - 1625

Published: May 1, 2024

Consciousness can be conceptualized as varying along at least two dimensions: the global state of consciousness and content conscious experience. Here, we highlight cellular systems-level contributions thalamus to then argue for thalamic content, including integrated, segregated, continuous nature our We underscore vital, yet distinct roles core- matrix-type neurons. Through reciprocal interactions with deep-layer cortical neurons, matrix neurons support wakefulness determine perceptual thresholds, whereas core maintain enable constancy. further propose that integration, segregation, continuity depend on convergent corticothalamic projections enabling dimensionality reduction, a reticular nucleus-mediated divisive normalization-like process, sustained coherent activity in thalamocortical loops, respectively. Overall, conclude plays central topological role brain structures controlling

Language: Английский

Citations

22
The neural activity of auditory conscious perception DOI Creative Commons
Kate L. Christison-Lagay, Aya Khalaf,

Noah C. Freedman

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121041 - 121041

Published: Jan. 1, 2025

Although recent work has made headway in understanding the neural temporospatial dynamics of conscious perception, much that focused on visual paradigms. To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we test within auditory domain. Participants completed an threshold task while undergoing intracranial electroencephalography. Recordings from >2,800 grey matter electrodes were analyzed broadband gamma power (a range which reflects local activity). For perceived trials, find nearly simultaneous activity early regions, right caudal middle frontal gyrus, and non-auditory thalamus; followed by a wave sweeps through association regions into parietal cortices. not significant is restricted to regions. These findings show cortical subcortical networks involved perception similar those observed with vision, suggesting perception.

Language: Английский

Citations

4
Bistability of prefrontal states gates access to consciousness DOI Open Access
Abhilash Dwarakanath, Vishal Kapoor,

Joachim Werner

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(10), P. 1666 - 1683.e4

Published: March 14, 2023

Language: Английский

Citations

25
An integrative view of the role of prefrontal cortex in consciousness DOI
Theofanis I. Panagiotaropoulos

Neuron, Journal Year: 2024, Volume and Issue: 112(10), P. 1626 - 1641

Published: May 1, 2024

Language: Английский

Citations

9
Quality space computations for consciousness DOI Creative Commons
Stephen M. Fleming, Nicholas Shea

Trends in Cognitive Sciences, Journal Year: 2024, Volume and Issue: 28(10), P. 896 - 906

Published: July 17, 2024

Language: Английский

Citations

8
Testing the role of spontaneous activity in visuospatial perception with patterned optogenetics DOI Creative Commons
Kengo Takahashi,

Samuel Pontes Quero,

Julien Fiorilli

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0318863 - e0318863

Published: Feb. 27, 2025

A major debate in the field of consciousness pertains to whether neuronal activity or rather causal structure neural circuits underlie generation conscious experience. The former position is held by theoretical accounts based on predictive processing framework (such as neurorepresentationalism and active inference), while latter posited integrated information theory. This protocol describes an experiment, part a larger adversarial collaboration, that was designed address this question through combination behavioral tests mice, functional imaging, patterned optogenetics electrophysiology. experiment will directly test if optogenetic inactivation portion visual cortex not responding behaviorally relevant stimuli affect perception spatial distribution these stimuli, even when neurons being inactivated display no very low spiking activity, so it does induce significant effect other cortical areas. results be compared against predictions, provide contribution towards understanding what substrate is.

Language: Английский

Citations

1
Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop DOI
Zepeng Fang, Yuanyuan Dang,

Anan Ping

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6742)

Published: April 4, 2025

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it not clear how those and thalamocortical interactions directly contribute the transient process of human perception. We simultaneously recorded stereoelectroencephalography data from prefrontal cortex (PFC), while patients implanted electrodes performed a visual consciousness task. Compared ventral PFC, intralaminar medial presented earlier stronger consciousness-related activity. Transient thalamofrontal neural synchrony cross-frequency coupling were both driven by θ phase during The thus play gate role drive PFC emergence

Language: Английский

Citations

1
Illusory object recognition is either perceptual or cognitive in origin depending on decision confidence DOI Creative Commons
Josipa Alilović,

Eline Lampers,

Heleen A. Slagter

et al.

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(3), P. e3002009 - e3002009

Published: March 2, 2023

We occasionally misinterpret ambiguous sensory input or report a stimulus when none is presented. It unknown whether such errors have origin and reflect true perceptual illusions, they more cognitive (e.g., are due to guessing), both. When participants performed an error-prone challenging face/house discrimination task, multivariate electroencephalography (EEG) analyses revealed that during decision mistaking face for house), stages of visual information processing initially represent the presented category. Crucially however, were confident in their erroneous decision, so illusion was strongest, this neural representation flipped later time reflected incorrectly reported percept. This flip pattern absent decisions made with low confidence. work demonstrates confidence arbitrates between errors, which illusions perception, do not.

Language: Английский

Citations

15
An adversarial collaboration to critically evaluate theories of consciousness DOI Creative Commons
Lucía Melloni,

Cogitate Consortium,

Oscar Ferrante

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: June 28, 2023

Abstract Different theories explain how subjective experience arises from brain activity1,2. These have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 Global Neuronal Workspace (GNWT)6-10, employing a theory-neutral consortium approach11,12. We investigate neural correlates of content duration visual experience. The theory proponents developed preregistered experimental design, divergent predictions, expected outcomes, their interpretation12. 256 human subjects viewed suprathreshold stimuli for variable durations while activity was measured with functional magnetic resonance imaging, magnetoencephalography, electrocorticography. find information about conscious visual, ventro-temporal inferior frontal cortex, sustained responses occipital lateral temporal cortex reflecting stimulus duration, content-specific synchronization between early areas. results confirm some predictions IIT GNWT, substantially challenging both theories: IIT, lack within posterior contradicts claim that network connectivity specifies consciousness. GNWT is challenged by general ignition at offset limited representation certain dimensions prefrontal cortex. Beyond themselves, alternative approach to advance cognitive neuroscience through principled, theory-driven, collaborative effort. highlight challenges change people’s mind 13 need quantitative framework integrating evidence systematic testing building.

Language: Английский

Citations

14