Computational modelling shows evidence in support of both sensory and frontal theories of consciousness DOI Creative Commons
Kavindu H. Bandara, Elise G. Rowe, Marta I. Garrido

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Abstract The role of the prefrontal cortex (PFC) in consciousness is hotly debated. Frontal theories argue that PFC necessary for consciousness, while sensory propose arises from recurrent activity posterior alone, with resulting mere act reporting. To resolve this dispute, we re-analysed an EEG dataset 30 participants a no-report inattentional blindness paradigm where faces are (un)consciously perceived. Dynamic causal modelling was used to estimate effective connectivity between key contended brain regions, and cortices. Then, second-level parametric empirical Bayesian model conducted determine how modulated by awareness task-relevance. While initial data-driven search could not corroborate neither nor frontal more directed hypothesis-driven analysis revealed strong evidence both explain data, very slight preference theories. Specifically, backward connections switched off within explained better (53%) than without regions. Our findings provide some support subtle, yet crucial, contribution highlight need revise current consciousness.

Language: Английский

Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop DOI
Zepeng Fang, Yuanyuan Dang,

Anan Ping

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6742)

Published: April 4, 2025

Human high-order thalamic nuclei activity is known to closely correlate with conscious states. However, it not clear how those and thalamocortical interactions directly contribute the transient process of human perception. We simultaneously recorded stereoelectroencephalography data from prefrontal cortex (PFC), while patients implanted electrodes performed a visual consciousness task. Compared ventral PFC, intralaminar medial presented earlier stronger consciousness-related activity. Transient thalamofrontal neural synchrony cross-frequency coupling were both driven by θ phase during The thus play gate role drive PFC emergence

Language: Английский

Citations

1
Characterization of neuronal spiking patterns in the medial prefrontal cortex under varied general anesthetics in mice DOI Creative Commons
Xiangyu Hu,

Jingyao Jiang,

Yu Leng

et al.

Anesthesiology and Perioperative Science, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 25, 2025

Abstract Purpose The mechanisms underlying reversible unconsciousness induced by general anesthetics remain unclear. This study aimed to investigate the effects of four commonly used on neuronal spiking patterns in layer 5 medial prefrontal cortex (mPFC). Methods In vivo multi-channel recordings were performed mPFC a mouse model. Neuronal regular-spiking and fast-spiking neurons measured compared across wakefulness loss righting reflex (LORR), recovery (RORR). Four anesthetic/sedative drugs (sevoflurane, propofol, ketamine, dexmedetomidine) tested. Results During LORR, most cortical inhibited, while small subset was excited. Fast-spiking exhibited significant suppression all anesthetics. Among these, firing rate inhibited closely associated with transitions between LORR RORR. Sevoflurane, dexmedetomidine similar modulatory neurons, whereas ketamine stronger excitatory both regular- neurons. Conclusions exert comparable mPFC, induces distinct effects. Inhibited are

Language: Английский

Citations

0
Electroencephalographic characteristics of transcutaneous auricular vagus nerve stimulation for prolonged disorders of consciousness: a study protocol DOI Creative Commons
Haoyang Jiao,

Weihang Zhai,

Jinling Zhang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: May 6, 2025

Background Increasing evidence indicates that transcutaneous auricular vagus nerve stimulation (taVNS) can promote the recovery of consciousness levels in patients with prolonged disorders (pDOC). However, previous clinical studies have shown inconsistent efficacy taVNS treating pDOC. This could be because no research has clearly defined indications for treatment pDOC, and who were not indicated included. Therefore, screening out pDOC are suitable is a key scientific issue requires urgent resolution at present. Methods/design We aim to incorporate 50 into this study. All will undergo 4-week treatment, 30-min resting electroencephalogram (EEG) Coma Recovery Scale-Revised (CRS-R) scores each patient collected before after treatment. After followed up first, third, sixth, twelfth months The classified response non-response groups based on whether their CRS-R increase. differences brain power spectrum functional connectivity EEG enrollment between two compared. Discussion objective experiment screen characteristics by using technology, lay foundation wider application Clinical trial registration Identifier ITMCTR2024000734, http://itmctr.ccebtcm.org.cn/ .

Language: Английский

Citations

0
The role of the prefrontal cortex in modulating aggression in humans and rodents DOI
Xinyang Li, Lize Xiong, Yan Li

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 115285 - 115285

Published: Oct. 1, 2024

Language: Английский

Citations

1
A decision-theoretic model of multistability: perceptual switches as internal actions DOI Creative Commons
Shervin Safavi, Peter Dayan

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract Perceptual multistability has been studied for centuries using a diverse collection of approaches. Insights derived from this phenomenon range core principles information processing, such as perceptual inference, to high-level concerns, visual awareness. The dominant computational explanations are based on the Helmholtzian view perception inverse inference. However, these approaches struggle account crucial role played by value, e.g., with percepts paired reward dominating longer periods than unpaired ones. In study, we formulate in terms dynamic, value-based, choice, employing formalism partially observable Markov decision process (POMDP). We use binocular rivalry an example, considering different explicit and implicit sources (and punishment) each percept. resulting values time-dependent influenced novelty form exploration. solution POMDP is optimal policy, show that can replicate explain several characteristics rivalry, ranging classic hallmarks apparently spontaneous random switches approximately gamma-distributed dominance more subtle aspects rich temporal dynamics switching rates. Overall, our decision-theoretic perspective not only accounts wealth unexplained data, but also opens up modern conceptions internal reinforcement learning service understanding phenomena, sensory processing generally.

Language: Английский

Citations

0
Single neuron diversity supports area functional specialization along the visual cortical pathways DOI Creative Commons

Michael Feyerabend,

Stefan Pommer,

MS Jimenez-Sosa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic features, whereas downstream in the lateral prefrontal cortex (LPFC) acquire tuning for novel complex feature associations. It has been assumed each is repeatable neuronal subtypes, variations synaptic strength connectivity patterns underlie functional specialization. Here we test hypothesis diversity intrinsic make-up single contributes to specialization along pathways. We measured morphological electrophysiological properties areas LPFC marmosets. Excitatory were larger, less excitable, fired broader spikes than neurons. Some inhibitory fast spiking interneurons had longer axons with latencies a more depolarized action potential trough V1. Intrinsic bursting was found subpopulations both excitatory but not latter may favour temporal summation therefore enhanced plasticity relative Our results show within primate system permeates most processing level, neuron.

Language: Английский

Citations

0
When sensory input meets spontaneous brain activity DOI Creative Commons
Natalia Zaretskaya

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(10), P. 749 - 750

Published: Aug. 31, 2024

A recent study by Wu, Podvalny, and colleagues investigated how ongoing spontaneous brain activity interacts with sensory input shapes conscious perception. It reports diverse effects of prestimulus in several key networks, revealing new roles the prefrontal cortex default mode network perception consciousness.

Language: Английский

Citations

0
Computational modelling shows evidence in support of both sensory and frontal theories of consciousness DOI Creative Commons
Kavindu H. Bandara, Elise G. Rowe, Marta I. Garrido

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

Abstract The role of the prefrontal cortex (PFC) in consciousness is hotly debated. Frontal theories argue that PFC necessary for consciousness, while sensory propose arises from recurrent activity posterior alone, with resulting mere act reporting. To resolve this dispute, we re-analysed an EEG dataset 30 participants a no-report inattentional blindness paradigm where faces are (un)consciously perceived. Dynamic causal modelling was used to estimate effective connectivity between key contended brain regions, and cortices. Then, second-level parametric empirical Bayesian model conducted determine how modulated by awareness task-relevance. While initial data-driven search could not corroborate neither nor frontal more directed hypothesis-driven analysis revealed strong evidence both explain data, very slight preference theories. Specifically, backward connections switched off within explained better (53%) than without regions. Our findings provide some support subtle, yet crucial, contribution highlight need revise current consciousness.

Language: Английский

Citations

0