Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Background Social behavior and social organization have major influences on individual health fitness. Yet, biomedical research focuses studying a few genotypes under impoverished conditions. Understanding how lab conditions modified organizations of model organisms, such as mice, relative to natural populations is missing link between socioecology science. Results Using common garden design, we describe the formation structure in well-studied laboratory mouse strain, C57BL/6J, replicated mixed-sex over 10-day trials compared control with wild-derived outbred house mice outdoor field enclosures. We focus three key features systems: (i) territory establishment males, (ii) female relationships, (iii) networks formed by populations. Male territorial behaviors were similar but muted C57 mice. Female sharply differed from females, showing little bias toward cage mates exploring substantially more enclosures all other groups. consistently generated denser than Conclusions individually vary their spatial which scale shape overall organization. The repeatable societies highlights opportunities experimentally study interplay society biology using organisms.

Language: Английский

---

Neural control of sex differences in affiliative and prosocial behaviors

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106039 - 106039

Published: Feb. 1, 2025

Social interactions are vital for various taxa and species. Prosocial affiliative dynamics within a group between individuals not only pleasurable rewarding, but also appear to actively contribute well-being, cognitive performance, disease prevention. Moreover, disturbances in acting or being prosocial can represent major burden an individual their affective partners. These disruptions evident across spectrum of neuropsychiatric conditions, including depression autism disorders. Importantly, interactive patterns behavior vary with sex. The fact that genders differentially affected by disorders associated social impairment underscores the high importance this research uncovering underlying neural correlates mechanisms. This review focuses on elucidating sex-related differences behaviors potential association sexually different correlates. Specifically, we aim shed light complex interplay sex, behavior, neurobiology interaction patterns.

Language: Английский

---

Sexually dimorphic oxytocin circuits drive intragroup social conflict and aggression in wild house mice

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(8), P. 1565 - 1573

Published: July 5, 2024

Language: Английский

---

Re-wilding model organisms: Opportunities to test causal mechanisms in social determinants of health and aging

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105238 - 105238

Published: May 22, 2023

Language: Английский

---

Sex diversity in the 21st century: Concepts, frameworks, and approaches for the future of neuroendocrinology

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 157, P. 105445 - 105445

Published: Nov. 17, 2023

Sex is ubiquitous and variable throughout the animal kingdom. Historically, scientists have used reductionist methodologies that rely on a priori sex categorizations, in which two discrete sexes are inextricably linked with gamete type. However, this binarized operationalization does not adequately reflect diversity of observed nature. This due, part, to fact exists across many levels biological analysis, including genetic, molecular, cellular, morphological, behavioral, population levels. Furthermore, mechanisms governing embedded complex networks dynamically interact other systems. To produce most accurate scientifically rigorous work examining neuroendocrinology capture full range variability present systems, we must critically assess frameworks, experimental designs, analytical methods our research. In perspective piece, first propose new conceptual framework guide integrative study sex. Then, provide practical guidance research approaches for studying sex-associated variables, factors consider design, selection model organisms, methodologies, statistical analyses. We invite fellow conscientiously apply these modernized advance understanding encourage academically socially responsible outcomes work. By expanding frameworks methodological sex, will gain insight into unique ways organization vast array

Language: Английский

---

Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution

Nature Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

---

Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Summary Social organization and division of labor are fundamental to animal societies, but how do these structures emerge from individual interactions, what role does neuromodulation play in shaping them? Using behavioral tracking a semi-natural environment, neural recordings, computational models integrating reinforcement social learning, we show that groups three isogenic mice spontaneously develop specialized roles while solving foraging task requiring decisions under constraints. Moreover, shaped by dopaminergic activity the ventral tegmental area. Strikingly, despite minor sex-differences behavior when were tested alone, male triads formed stable worker-scrounger relationships driven competition, whereas female adopted uniform, cooperative strategies. Model analysis revealed intra- inter-sex parameter differences resource exploitation, combined with contingent dynamic drive specialization division. Most notably, it highlighted contingency, amplified magnifies shapes profiles. The plastic, adaptive nature within was confirmed manipulating cell activity, which reshaped altered group structure. Our findings support feedback loop where context states, turn reinforce stabilize structures.

Language: Английский

---

Mammalian olfactory cortex neurons retain molecular signatures of ancestral cell types

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 14, 2023

Abstract The cerebral cortex diversified extensively during vertebrate evolution. Intriguingly, the three-layered mammalian olfactory resembles cortical cytoarchitecture of non-mammals yet evolved alongside six-layered neocortex, enabling unique comparisons for investigating neuron diversification. We performed single-nucleus multiome sequencing across mouse three- to cortices and compared types mice, reptiles salamander. identified neurons that are cortex-specific or conserved areas. However, transcriptomically similar exhibited area-specific epigenetic states. Additionally, showed transcriptomic divergence between lab wild-derived suggesting enhanced circuit plasticity through adult immature neurons. Finally, displayed marked similarities reptile salamander Together, these data indicate retains molecular signatures representative ancestral traits.

Language: Английский

---

Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Maternal malnutrition has been associated with neurodevelopmental deficits and long-term implications on the offspring's health behavior. Here, we investigated effects of maternal low-protein diet (LPD) or obesity-inducing high-fat (HFD) dyadic social interactions, group organization autism-related behaviors in mice. We found that HFD induced an behavioral phenotype male offspring, including a robust decrease sociability, increased aggression, cognitive rigidity repetitive behaviors. LPD led to milder yet significant effect symptoms, no olfactory-mediated Under naturalistic conditions setting, this manifested altered repertoires, magnitude dominance relations, reduced interactions novel stimuli but not offspring. Finally, HFD-induced transcriptomic changes olfactory bulbs Together, our findings show induces long-lasting aggression potential impairments brain regions processing chemosensory signals.

Language: Английский

---

Induction of territorial behavior and dominance hierarchies in laboratory mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 23, 2024

Abstract Territorial behaviors comprise a set of coordinated actions and response patterns found across animal species that promote the exclusive access to resources. House mice are highly territorial with subset males consistently attacking chasing competing expel them from their territories performing urine marking signal extent territories. Natural variation in within mouse colony leads formation dominance hierarchies which subordinate can reside territory dominant male. While full repertoire such has been extensively studied wild-derived semi-natural enclosures, so far they have not established smaller enclosures genetically-defined laboratory strains required for application neural recording manipulation methods. Here, we present protocol induce an extensive small mice, including method simultaneous tracking behavior pairs. Using this describe emergence robust dominant-subordinate between pairs CD1 outbred or CD1xB6 F1 hybrid but unexpectedly C57BL/6 inbred animals. Our behavioral paradigm opens door neurocircuit studies social hierarchy laboratory.

Language: Английский

---