Opposing effects of rewarding and aversive stimuli on D1 and D2 types of dopamine-sensitive neurons in the central amygdala DOI Creative Commons
Anna Beroun, Łukasz Bijoch,

Paweł Szczypkowski

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Dopamine-sensitive neurons are organized in two classes of cells, expressing D1- or D2- types dopamine receptors, and often mediating opposing aspects reward-oriented behaviors. Here, we focused on dopamine-sensitive the central amygdala – a brain structure critically involved processing emotion-related stimuli. Exposing mice to rewarding aversive stimuli studied DRD1 DRD2 cells activity using in vivo two-photon calcium imaging CeM. We showed that cocaine sugar predominantly increase DRD1(+) decrease DRD2(+) cells. Repeated exposure cocaine, however, had opposite effect spontaneous excitatory synaptic transmission CeM than sugar. Quinine, an stimulus, primarily engaged neurons, activating those were previously inhibited by exposure. Our results show though populations differentially regulated appetitive/aversive stimuli, both participate sugar, quinine processing.

Language: Английский

Cross-modal cortical circuit for sound sensitivity in neuropathic pain DOI

Yunfeng Mao,

Mingjun Zhang,

Xiaoqi Peng

et al.

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Auditory Cortex Learns to Discriminate Audiovisual Cues through Selective Multisensory Enhancement DOI Open Access
Song Chang,

Beilin Zheng,

Les Keniston

et al.

Published: April 2, 2025

Multisensory object discrimination is essential in everyday life, yet the neural mechanisms underlying this process remain unclear. In study, we trained rats to perform a two-alternative forced-choice task using both auditory and visual cues. Our findings reveal that multisensory perceptual learning actively engages cortex (AC) neurons audiovisual processing. Importantly, many AC exhibited experience-dependent associations between their preferences, displaying unique integration model. This model employed selective enhancement for auditory-visual pairing guiding contralateral choice, which correlated with improved discrimination. Furthermore, effectively distinguished whether preferred stimulus was paired its associated distinct integrative mechanism. results highlight capability of sensory cortices develop sophisticated strategies, adapting demands enhance abilities.

Language: Английский

Citations

0
Auditory cortex learns to discriminate audiovisual cues through selective multisensory enhancement DOI Creative Commons
Song Chang,

Beilin Zheng,

Les Keniston

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: April 22, 2025

Multisensory object discrimination is essential in everyday life, yet the neural mechanisms underlying this process remain unclear. In study, we trained rats to perform a two-alternative forced-choice task using both auditory and visual cues. Our findings reveal that multisensory perceptual learning actively engages cortex (AC) neurons audiovisual processing. Importantly, many AC exhibited experience-dependent associations between their preferences, displaying unique integration model. This model employed selective enhancement for auditory-visual pairing guiding contralateral choice, which correlated with improved discrimination. Furthermore, effectively distinguished whether preferred stimulus was paired its associated distinct integrative mechanism. results highlight capability of sensory cortices develop sophisticated strategies, adapting demands enhance abilities.

Language: Английский

Citations

0
Survey of hippocampal responses to sound in naïve mice reveals widespread activation by broadband noise onsets DOI Creative Commons
James H. Bigelow,

Toshiaki SUZUKI,

Yulang Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Abstract Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naïve subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes record unit activity HC auditory cortex (ACtx) awake, untrained mice during presentation diverse sound stimuli. A subset exhibited reliable, short-latency passive sounds, including tones broadband noise. units showed evidence tuning for tone frequency not spectrotemporal features continuous dynamic moving ripples. Across types, overwhelmingly occurred at stimulus onset; they quickly adapted did offset. Among all tested, noise was by far most effective driving activity, with response scaling increasing spectral bandwidth density. Responses were also more common than visual flash Sound-evoked face movements, quantified total facial motion energy (FME), correlated population-level many individual responded regardless movement, indicating both motor-related inputs. These results show that abrupt, acoustic events are sufficient activate absence learning or behavioral engagement. This suggests a possible role detecting salient environmental changes supports idea inputs contribute directly function. Given emerging links between hearing loss dementia, findings highlight potential pathway which deafferentation could impact cognitive health.

Language: Английский

Citations

0
Facial expressions in mice reveal latent cognitive variables and their neural correlates DOI Creative Commons
Fanny Cazettes, Davide Reato, Elisabete Augusto

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 2, 2024

Brain activity controls adaptive behavior but also drives unintentional incidental movements. Such movements could thus potentially be used to read out internal cognitive variables neurally computed. Establishing this, however, would require ruling that reflect cognition only because they are coupled with task-related responses through the biomechanics of body. We addressed this issue in a foraging task for mice where multiple decision simultaneously encoded even if, at any given time, one them is used. found characteristic features face encode not currently variables, independent and unexpressed ones, we show these partially originate from neural secondary motor cortex. Our results suggest reflects ongoing computations above beyond those related demands, demonstrating ability noninvasive monitoring expose otherwise latent states.

Language: Английский

Citations

2
Rapid sensorimotor adaptation to auditory midbrain silencing in free-flying bats DOI
Clarice A. Diebold, Jennifer Lawlor, Kathryne M. Allen

et al.

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

2
Auditory neuroscience: Sounds make the face move DOI
Alessandro La Chioma, David M. Schneider

Current Biology, Journal Year: 2024, Volume and Issue: 34(9), P. R346 - R348

Published: May 1, 2024

Language: Английский

Citations

1
Sensation and expectation are embedded in mouse motor cortical activity DOI Creative Commons
Brooke E. Holey, David M. Schneider

Cell Reports, Journal Year: 2024, Volume and Issue: 43(7), P. 114396 - 114396

Published: June 25, 2024

During behavior, the motor cortex sends copies of motor-related signals to sensory cortices. Here, we combine closed-loop behavior with large-scale physiology, projection-pattern-specific recordings, and circuit perturbations show that neurons in mouse secondary (M2) encode sensation are influenced by expectation. When a movement unexpectedly produces sound, M2 becomes dominated sound-evoked activity. Sound responses inherited partially from auditory routed back cortex, providing path for reciprocal exchange sensory-motor information during behavior. acoustic consequences become predictable, self-generated sounds selectively gated off. These changes single-cell reflected population dynamics, which both Together, these findings reveal embedding expectation cortical

Language: Английский

Citations

1
Opposing effects of rewarding and aversive stimuli on D1 and D2 types of dopamine-sensitive neurons in the central amygdala DOI Open Access
Łukasz Bijoch,

Paweł Szczypkowski,

Justyna Wiśniewska

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Dopamine-sensitive neurons are organized in two classes of cells, expressing D1- or D2- types dopamine receptors, and often mediating opposing aspects reward-oriented behaviors. Here, we focused on dopamine-sensitive the central amygdala – a brain structure critically involved processing emotion-related stimuli. We discovered that both receptor present medial nucleus, while lateral part is populated predominantly with DRD2 cells. Exposing mice to rewarding aversive stimuli studied DRD1 cells activity using vivo two-photon calcium imaging CeM. showed cocaine sugar increase DRD1(+) decrease DRD2(+) Repeated exposure cocaine, however, had opposite effect spontaneous excitatory synaptic transmission CeM than sugar. Quinine, an stimulus, primarily engaged neurons, activating those were previously inhibited by exposure. Our results show though populations differentially regulated appetitive/aversive stimuli, participate sugar, quinine processing.

Language: Английский

Citations

1
Hyperacusis in Tinnitus Individuals Is Associated with Smaller Gray Matter Volumes in the Supplementary Motor Area Regardless of Hearing Levels DOI Creative Commons
Punitkumar Makani, Marc Thioux, Elouise A. Koops

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 726 - 726

Published: July 19, 2024

Recent evidence suggests a connection between hyperacusis and the motor system of brain. For instance, our recent study reported that in participants with tinnitus hearing loss is associated smaller gray matter volumes supplementary area (SMA). Given can affect changes tinnitus, this aimed to determine if previous findings SMA persist absence loss. Data for were gathered from four prior studies conducted 2004 2019 at University Medical Centre Groningen (UMCG). A total 101 either clinically normal (normal or NHT, n = 35) bilateral sensorineural (hearing HLT, 66) included across studies. Hyperacusis was determined by score ≥22 on Questionnaire (HQ). In NHT group, 22 (63%) scored HQ (NHT hyperacusis: mean age 44.1 years, 12 females), while HLT 25 (38%) (HLT 59.5 10 females). The 2 × between-group ANOVAs revealed volumes, regardless levels. Notably, primarily influenced attentional subscales HQ. association may indicate constant alertness sounds readiness action.

Language: Английский

Citations

1