The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1879(1), P. 189052 - 189052

Published: Dec. 12, 2023

Language: Английский

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Rapid Detection of the Anti-Tumor Drug Etoposide in Biological Samples by Using a Nanoporous-Gold-Based Electrochemical Sensor

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1060 - 1060

Published: Feb. 28, 2024

Monitoring etoposide is important due to its wide usage in anti-tumor therapy; however, the commonly used HPLC method expensive and often requires complicated extraction detection procedures. Electrochemical analysis has great application prospects because of rapid response high specificity, sensitivity, efficiency with low cost convenience. In this study, we constructed a nanoporous gold (NPG)-modified GCE for etoposide. The electrochemical oxidation by NPG caused sensitive current peak at +0.27 V good reproductivity 50 mM phosphate buffer (pH 7.4). relationship between concentration was linear range 0.1 20 μM 150 μM, sensitivity 681.8 μA mM−1 cm−2 197.2 cm−2, respectively, limit (LOD) reaching nM. electrode had anti-interference ability several common anions cations. Spiked recovery tests serum, urine, fermentation broth verified excellent performance sensor terms reproducibility, specificity. This may provide promising tool biological samples.

Language: Английский

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CAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 15, 2025

Abstract CAR-T cell therapies have risen to prominence over the last decade, and their indications are increasing with several products approved as early second line in Large B Cell non-Hodgkin Lymphomas. Their major toxicities cytokine release syndrome (CRS) Immune-effector Associated Neurotoxicity Syndrome (ICANS). These entities involve a hyperinflammatory cascade which is amplified through mononuclear phagocytic system (MPS). Herein, we review immune mediated adverse events related CAR therapy, including pathophysiologies, current therapies. In particular, discuss emerging role of MPS both toxicity efficacy possible avenues for modulation optimize while minimizing toxicity.

Language: Английский

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Antitumor and immunomodulatory activities of diphyllin and its derivatives

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118197 - 118197

Published: April 1, 2025

Language: Английский

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Unveiling the Mystery of Adult-Onset Still’s Disease: A Compelling Case Report

Life, Journal Year: 2024, Volume and Issue: 14(2), P. 195 - 195

Published: Jan. 29, 2024

Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder. Diagnosis can take long time, especially in the presence of confounding factors, and it is, to some extent, process exclusion. AOSD has life-threating complications ranging from asymptomatic severe, such as macrophage activation syndrome (MAS), which also referred hemophagocytic lymphohistocytosis (HLH). This condition correlated with cytokine storm production monocyte/macrophage overactivation typically occurs rash, pyrexia, pancytopenia, hepatosplenomegaly involvement. Exitus approximately 10% cases. For treatment MAS-HLH, Histiocyte Society currently suggests high-dose corticosteroids, possible addition cyclosporine A, anti-interleukin (IL)-1, or IL-6 biological drugs; inclusion etoposide recommended for most severe conditions. In all cases, multidisciplinary collaboration involving resources expertise several specialists (e.g., rheumatologist, infectiologist, critical care medicine specialist) advised. Herein, we provide detailed description clinical case previously healthy young woman MAS developed dramatic onset manifestation whose diagnosis posed real challenge; was finally resolved by applying HLH-94 protocol (i.e., combination dexamethasone).

Language: Английский

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Fabrication of lactoferrin-chitosan-etoposide nanoparticles with melatonin via carbodiimide coupling: In-vitro & in-vivo evaluation for colon cancer

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 810 - 841

Published: Dec. 6, 2024

Language: Английский

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Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117617 - 117617

Published: Dec. 31, 2024

Language: Английский

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Unveiling the Mystery of Adult-Onset Still's Disease: a Compelling Case Report

Published: Jan. 3, 2024

Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder. Diagnosis can take long time, especially in the presence of confounding factors, and it is, at least part, exclusion. AOSD generally mild, however small percentage patients develop fearsome as well potentially fatal complication, macrophage activation syndrome (MAS), which also referred to hemophagocytic lymphohistocytosis (HLH). This condition correlated with cytokine storm production monocyte/macrophage overactivation, typically occurs rash, pyrexia, pancytopenia, hepatosplenomegaly involvement. Exitus approximately 10% cases. The Histiocyte Society, nonprofit organization committed improving lives histiocytic disorders, currently suggests etoposide combination dexamethasone for treatment HLH/MAS, although multidisciplinary collaboration using resources expertise several specialists (e.g. rheumatologist, infectiologist, critical care medicine specialist) always recommended. Hereby we propose detailed description clinical case previously healthy young woman MAS was dramatic onset manifestation whose diagnosis posed real challenge.

Language: Английский

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Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

RSC Advances, Journal Year: 2023, Volume and Issue: 13(47), P. 33080 - 33095

Published: Jan. 1, 2023

Breast cancer is a global health concern, with increasing disease burden and disparities in access to healthcare. Late diagnosis limited treatment options underserved areas contribute poor outcomes. In response this challenge, we developed novel family of 2-substituted-quinoxaline analogues, combining coumarin quinoxaline scaffolds known for their anticancer properties. Through versatile synthetic approach, designed, synthesized, characterized set 2-substituted derivatives. The antiproliferative activity the synthesized compounds was assessed toward MCF-7 breast cells. Our investigations showed that exhibit considerable Notably, compound 3b, among examined compounds, displayed superior inhibitory effect (IC

Language: Английский

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Preparation of etoposide liposomes for enhancing antitumor efficacy on small cell lung cancer and reducing hematotoxicity of drugs

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 198, P. 114239 - 114239

Published: March 6, 2024

Language: Английский

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