A Review of Immunological and Neuropsychobehavioral Effects of Latent Toxoplasmosis on Humans
Parasite Immunology,
Journal Year:
2024,
Volume and Issue:
46(7)
Published: July 1, 2024
ABSTRACT
Toxoplasmosis
as
a
zoonotic
disease
has
worldwide
distribution
and
can
infect
wide
range
of
animal
hosts,
well
at
least
one
third
the
world's
human
population.
The
is
usually
mild
or
asymptomatic
in
immunocompetent
individuals,
but
dormant
tissue
cysts
survive
especially
brain
for
host
lifespan,
known
latent
toxoplasmosis
(LT).
Recent
studies
suggest
that
LT
have
certain
neurological,
immunological
psychological
behavioural
effects
on
including
schizophrenia,
bipolar
disorder,
Alzheimer's
disease,
depression,
suicide
anxiety
sleeping
disorders.
are
controversial,
their
exact
mechanisms
action
not
yet
fully
understood.
This
review
aims
to
provide
an
overview
potential
effects,
basic
alteration
neurotransmitter
levels,
immune
activation
central
nervous
system
induction
oxidative
stress.
Additionally,
beneficial
LT,
explanation
within
framework
manipulation
hypothesis,
finally,
challenges
limitations
current
research
discussed.
Language: Английский
Frequency of exposure to Toxoplasma gondii in COVID-19 patients. a systematic review and meta-analysis
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 6, 2024
Abstract
Background
Toxoplasmosis
is
a
chronic
protozoan
parasitic
infection
that
affects
nearly
one-third
of
the
global
population.
During
COVID-19
pandemic,
cases
were
observed
in
patients
with
and
toxoplasmosis.
Therefore,
this
systematic
review
meta-analysis
aimed
to
determine
frequency
Toxoplasma
gondii
exposure
COVID-19.
Methods
A
literature
search
was
conducted
six
databases
(PubMed,
Scopus,
Embase,
Web
Science,
ScienceDirect,
Google
Scholar)
until
March
3,
2024.
Study
selection,
quality
assessment,
data
extraction
performed
independently
by
three
investigators.
Statistical
analysis
using
R
version
4.3,
applying
random-effects
model.
The
included
observational
studies
assessed
"JBI-MAStARI".
Results
total
5,936
retrieved,
13
which
final
meta-analysis.
sample
2,947
from
four
countries,
whom
approximately
43.26%
men
49.41%
women.
Among
patients,
1,323
showed
evidence
T.
through
IgG
detection,
while
1,302
specifically
examined
for
presence
IgM
36
positive
identified.
,
determined
COVID-19,
reached
49%
(95%
CI:
34-63%;
participants;
studies;
I
2
=
98%,
p
<
0.01).
In
addition,
evaluated
2%
0-6%;
6
94%,
Conclusion
It
shown
almost
half
had
previous
IgG,
small
percentage,
2%,
active
detection.
Language: Английский
Frequency of exposure to Toxoplasma gondii in COVID-19 patients: a systematic review and meta-analysis
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 19, 2024
Toxoplasmosis
is
a
chronic
protozoan
parasitic
infection
that
affects
nearly
one-third
of
the
global
population.
During
COVID-19
pandemic,
cases
were
observed
in
patients
with
and
toxoplasmosis.
Therefore,
this
systematic
review
meta-analysis
aimed
to
determine
frequency
Toxoplasma
gondii
exposure
COVID-19.
A
literature
search
was
conducted
six
databases
or
tools
(PubMed,
Scopus,
Embase,
Web
Science,
ScienceDirect,
Google
Scholar)
until
March
3,
2024.
Study
selection,
quality
assessment,
data
extraction
performed
independently
by
three
investigators.
Statistical
analysis
using
R
version
4.3,
applying
random-effects
model.
The
included
observational
studies
assessed
"JBI-MAStARI".
total
5,936
retrieved,
13
which
final
meta-analysis.
sample
2,947
from
four
countries,
whom
approximately
43.3%
men
49.4%
women.
Among
patients,
1,323
showed
evidence
T.
through
IgG
detection,
while
1,302
explicitly
examined
for
IgM
36
positive
identified.
gondii,
determined
presence
COVID-19,
reached
49%
(95%
CI:
34–63%;
participants;
studies;
I2
=
98%,
p
<
0.01).
In
addition,
evaluated
2%
0–6%;
6
94%,
It
shown
almost
half
had
previous
IgG,
small
percentage,
2%,
active
detection.
Although
results
indicate
possible
correlation
between
it
essential
note
study
based
on
research,
precludes
establishing
causal
relationship.
Consequently,
further
research
required
deepen
understanding
interaction
two
conditions.
Joanna
Briggs
Institute
Meta-Analysis
Statistics
Assessment
Review
Instrument
(JBI-MAStARI),
Prospective
International
Registry
Systematic
Reviews
(PROSPERO),
Preferred
Reporting
Items
Meta-Analyses
(PRISMA).
Language: Английский
Coinfection of Toxoplasma gondii and Other Microorganisms: A Systematic Review and Meta-Analysis
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2106 - 2106
Published: Oct. 21, 2024
Toxoplasmosis
is
a
disease
caused
by
the
intracellular
protozoan
Language: Английский