Immunologic Research, Journal Year: 2024, Volume and Issue: 72(4), P. 523 - 525
Published: March 11, 2024
Language: Английский
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 2, 2024
Abstract Normal brain functioning relies on high aerobic energy production provided by mitochondria. Failure to supply a sufficient amount of energy, seen in different disorders, including autism spectrum disorder (ASD), may have significant negative impact development and support functions. Mitochondrial dysfunction, manifested the abnormal activities electron transport chain impaired metabolism, greatly contributes ASD. The aberrant this organelle is such importance that ASD has been proposed as mitochondrial disease. It should be noted not only function In particular, these organelles are involved regulation Ca 2+ homeostasis, mechanisms programmed cell death, autophagy, reactive oxygen nitrogen species (ROS RNS) production. Several syndromes originated from mitochondria-related mutations display phenotype. Abnormalities handling ATP mitochondria affect synaptic transmission, plasticity, development, contributing ROS regulate activity permeability transition pore (mPTP). prolonged opening affects redox state mitochondria, impairs oxidative phosphorylation, activates apoptosis, ultimately leading death. A dysregulation between enhanced processes apoptosis inhibited autophagy leads accumulation toxic products brains individuals with Although many still investigated, whether they cause or consequence unknown, accumulating data show breakdown any functions contribute review, we discuss multifaceted role various aspects neuroscience.
Language: Английский
Citations
10
Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(2)
Published: Feb. 1, 2025
ABSTRACT Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by dysregulated immune responses and multi‐organ involvement. Dysregulation of apoptosis, key process for maintaining homeostasis, plays critical role in the pathogenesis SLE. MicroRNAs (miRNAs), small non‐coding RNAs that regulate gene expression, have emerged as important modulators apoptosis cells, influencing balance between tolerance autoimmunity. Objectives This review aims to comprehensively summarize recent advancements understanding roles miRNAs regulation within cells SLE, highlighting their therapeutic potential restoring mitigating progression. Results Aberrant expression specific contributes dysregulation SLE cells. Pro‐apoptotic miRNAs, such miR‐125b miR‐150, are often downregulated, leading enhanced survival autoreactive Conversely, anti‐apoptotic including miR‐21, upregulated, further disrupting delicate cell apoptosis. Dual‐function miR‐155, exhibit context‐dependent based on cellular environments target interactions. promotes persistence development Conclusions play modulating pathways, making them promising targets Restoring pro‐apoptotic could help reinstate reduce tissue damage. Future research should focus elucidating miRNA targetomes, improving delivery systems, addressing off‐target effects fully harness potential.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Jan. 2, 2024
Abstract Ovarian cancer (OVCA), a prevalent gynecological malignancy, ranks as the fourth most common among women. Mitotic Arrest Deficient 2 Like (MAD2L2), chromatin-binding protein and component of DNA polymerase ζ, has been previously identified an inhibitor tumor growth in colorectal cancer. However, roles MAD2L2 OVCA, including its expression, impact, prognostic significance, remain unclear. We employed bioinformatics tools, Cox Regression analysis, vitro cell experiments to investigate biological functions. Our findings reveal that typically undergoes genomic alterations, such amplifications deep deletions. Moreover, we observed overexpression mRNA OVCA patients, correlating with reduced survival rates, particularly those Grade IV tumors. Furthermore, analysis biofunctions indicated is predominantly localized organellar ribosome, engaging mainly NADH dehydrogenase activity. This was deduced from results gene ontology enrichment which also role structural constituent mitochondrial translation elongation. These were corroborated by KEGG pathway further revealing MAD2L2’s involvement metabolism death process. Notably, expression showed significant associations various immune cells, CD4+T CD8+T B natural killer Myeloid dendritic cells. Additionally, elevated levels found enhance proliferation migration The upregulation appears inhibit ferroptosis process, coinciding increased mTOR signaling activity these study identifies novel regulator ovarian progression offers new insights for treating OVCA.
Language: Английский
Citations
8
Environmental Research, Journal Year: 2024, Volume and Issue: 250, P. 118532 - 118532
Published: Feb. 22, 2024
Language: Английский
Citations
8
Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)
Published: March 25, 2024
Low crude protein (CP) formulations with supplemental amino acids (AA) are used to enhance intestinal health, reduce costs, minimize environmental impact, and maintain growth performance of pigs. However, extensive reduction dietary CP can compromise due limited synthesis non-essential AA availability bioactive compounds from supplements even when requirements met. Moreover, implementing a low formulation increase the net energy (NE) content in feeds causing excessive fat deposition. Additional supplementation functional AA, coupled could further health glucose metabolism, improving nitrogen utilization, performance. Three experiments were conducted evaluate effects on growing-finishing In Exp. 1, 90 pigs (19.7 ± 1.1 kg, 45 barrows gilts) assigned 3 treatments: CON (18.0% CP, supplementing Lys, Met, Thr), LCP (16.0% Thr, Trp, Val), LCPT (16.1% + 0.05% SID Trp). 2, 72 (34.2 4.2 kg BW) (17.7% meeting Trp); (15.0% Val, Ile, Phe); VLCP (12.8% Phe, His, Leu). 3, (54.1 5.9 treatments fed experimental diets for phases (grower finishing 2). Treatments (18.0%, 13.8%, 12.7% phases; (13.5%, 11.4%, 10.4% LCPG (14.1%, 12.8%, 11.1% Glu match CON). All had 2.6 Mcal/kg NE. overall, did not differ among treatments. The increased (P < 0.05) Claudin-1 expression duodenum jejunum. CAT-1, 4F2hc, B0AT expressions reduced G:F BUN. backfat thickness (BFT). BFT BUN, whereas insulin plasma. abundance Streptococcaceae, Erysipelotrichaceae, alpha diversity. When formulation, be by Ile without affecting NE is adjusted avoid Supplementation Trp above requirement or seems benefit as well improved utilization metabolism.
Language: Английский
Citations
8
Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)
Published: Jan. 24, 2024
Abstract Acute myeloid leukemia (AML), a prevalent form of in adults, is often characterized by low response rates to chemotherapy, high recurrence rates, and unfavorable prognosis. A critical barrier managing refractory or recurrent AML the resistance chemotherapy. Increasing evidence indicates that tumor cell metabolism plays crucial role progression, survival, metastasis, treatment resistance. Autophagy, an essential regulator cellular energy metabolism, increasingly recognized for its metabolic reprogramming AML. Autophagy sustains cells during chemotherapy not only providing but also facilitating rapid proliferation through supply components such as amino acids nucleotides. Conversely, state can influence activity autophagy. Their mutual coordination helps maintain intrinsic homeostasis, which significant contributor cells. This review explores recent advancements understanding interaction between autophagy cells, emphasizing their roles survival drug comprehensive interplay shed light on strategies, particularly under adverse conditions insight may pave way innovative targeted strategies.
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3613 - 3613
Published: March 23, 2024
Resveratrol is a polyphenol present in various plant sources. Studies have reported numerous potential health benefits of resveratrol, exhibiting anti-aging, anti-inflammatory, anti-microbial, and anti-carcinogenic activity. Due to the effects, resveratrol also being tested reproductive disorders, including female infertility. Numerous cellular, animal, even human studies were performed with focus on effect In this review, we reviewed some its molecular mechanisms action summarized animal regarding infertility, age-related polycystic ovary syndrome, endometriosis.
Language: Английский
Citations
7
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: April 7, 2024
Abstract Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with predominant intracellular lipid peroxidation. In recent years, ferroptosis has gained more interest people in the treatment mechanism targeted tumors. mTOR, always overexpressed tumor, controlling cell growth metabolic activities, an important role both autophagy ferroptosis. Interestingly, selective types autophay plays promoting ferroptosis, which related to mTOR some pathways (especially amino acids). this paper, we list main mechanisms linking signaling pathway further summarize current compounds targeting these ways. There are growing experimental evidences that may have effective impact many tumors, understanding could provide potential therapeutic approach for tumor treatment.
Language: Английский
Citations
6
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116614 - 116614
Published: April 25, 2024
Pseudolaric acid B (PAB), an isolated from the roots of Pseudolarix kaempferi gorden, has shown antitumour effects through multiple mechanisms action. The objective this study was to investigate anticancer effect PAB on non-small cell lung cancer (NSCLC) and its underlying mechanism. In our experiments, we observed that decreased viability, inhibited colony formation, induced cycle arrest, impeded scratch healing, increased apoptosis in H1975 H1650 cells. Additionally, treatment enhanced fluorescence intensity MDC staining NSCLC cells, upregulated protein expression microtubule-associated light chain 3 II (LC3 II), downregulated sequestosome 1 (SQSTM1/P62). Combined with chloroquine (CQ) levels LC3 P62 while decreasing Moreover, led significant mTOR inhibition AMPK activation. combined compound C (CC) autophagy apoptosis. Furthermore, intracellular reactive oxygen species (ROS) which correlated modulation AMPK/mTOR signalling pathway associated Finally, validated growth activity mechanism vivo using athymic nude mice bearing tumour conclusion, findings suggest can induce autophagic death ROS-triggered pathway, making it a promising candidate for future treatment.
Language: Английский
Citations
6
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Feb. 14, 2024
Age-related cognitive impairment represents a significant health concern, with the understanding of its underlying mechanisms and potential interventions being paramount importance. This study aimed to investigate effects hyperbaric oxygen therapy (HBOT) on function neuronal integrity in aged (22-month-old) C57BL/6 mice. Male mice were exposed HBOT for 2 weeks, spatial learning memory abilities assessed using Morris water maze. We employed transcriptome sequencing Gene Ontology (GO) term enrichment analysis examine gene expression profiles, particular attention given synapse-related genes. Our data indicated upregulation postsynapse organization, synapse axonogenesis GO terms, likely contributing improved performance. Moreover, hyperphosphorylation tau, hallmark many neurodegenerative diseases, was significantly reduced HBO-treated group, both vivo vitro . Transmission electron microscopy revealed ultrastructural alterations hippocampus including an increase number synapses size active zone, reduction demyelinated lesions, decreased “PANTHOS.” Furthermore, Western blot analyses confirmed PSD95, BDNF, Syn proteins, suggesting enhanced synaptic plasticity neurotrophic support. increased autophagy, as evidenced by elevated levels Beclin-1 LC3 proteins level p62 protein. Finally, we demonstrated that activated AMPK-mTOR signaling pathway, critical regulator autophagy. Notably, our findings provide novel insights into which ameliorates age-related impairment, therapeutic value this approach.
Language: Английский
Citations
4