Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
265, P. 115469 - 115469
Published: Sept. 22, 2023
This
study
aimed
to
determine
the
toxicity
standard
and
potential
risks
effects
of
polyamide
(PA)
exposure
on
neurotoxicity,
stress
indicators,
immune
responses
in
juvenile
crucian
carp
Carassius
carassius.
Numerous
microplastics
(MPs)
exists
within
aquatic
environments,
leading
diverse
detrimental
impacts
organisms.
The
C.
carassius
(mean
weight,
23.7
±
1.6
g;
mean
length,
13.9
1.4
cm)
were
exposed
PA
concentrations
0,
4,
8,
16,
32
64
mg/L
for
2
weeks.
Among
neurotransmitters,
acetylcholinesterase
(AChE)
activity
liver,
gill,
intestine
was
significantly
inhibited
by
exposure.
Stress
indicators
such
as
cortisol
heat
shock
protein
70
(HSP70)
increased,
while
lysozyme
immunoglobulin
M
(IgM)
decreased.
Our
demonstrates
toxic
MP
carp's
responses.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2316 - 2316
Published: Jan. 24, 2023
Heterotis
niloticus
is
a
basal
teleost,
belonging
to
the
Osteoglossidae
family,
which
widespread
in
many
parts
of
Africa.
The
digestive
tract
H.
presents
similar
characteristics
those
higher
vertebrates,
exhibiting
gizzard-like
stomach
and
lymphoid
aggregates
intestinal
lamina
propria.
adaptive
immune
system
teleost
fish
linked
with
each
their
mucosal
body
surfaces.
In
fish,
gut-associated
tissue
(GALT)
generally
diffuse
that
represents
an
important
line
defense
against
pathogens
inhabiting
external
environment
can
enter
through
food.
GALT
comprises
intraepithelial
lymphocytes,
reside
epithelial
layer,
propria
leukocytes,
consist
macrophages,
granulocytes,
dendritic-like
cells.
This
study
aims
characterize,
for
first
time,
leukocytes
present
niloticus,
by
confocal
immuno-
fluorescence
techniques,
using
specific
antibodies:
toll-like
receptor
2,
major
histocompatibility
complex
class
II,
S100
protein,
serotonin,
CD4,
langerin,
inducible
nitric
oxide
synthetase.
Our
results
show
massive
cells
thickness
submucosa,
arranged
circumscribed
oval-shaped
structures
are
morphologically
isolated
follicles
birds
mammals,
thus
expanding
our
knowledge
about
immunity
shown
this
fish.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Feb. 27, 2023
Abstract
The
co-evolution
between
secretory
immunoglobulins
(sIgs)
and
microbiota
began
with
the
emergence
of
IgM
over
half
a
billion
years
ago.
Yet,
function
in
vertebrates
is
mostly
associated
systemic
immunity
against
pathogens.
sIgA
sIgT
are
only
sIgs
known
to
be
required
control
homeostasis
warm-
cold-blooded
respectively.
Recent
studies
have
shown
that
sIgM
coats
large
proportion
gut
humans
teleost
fish,
thus
suggesting
an
ancient
conserved
relationship
early
vertebrate
evolution.
To
test
this
hypothesis,
we
temporarily
selectively
depleted
from
rainbow
trout,
old
bony
fish
species.
depletion
resulted
drastic
reduction
coating
levels
losses
gutassociated
bacteria.
These
were
accompanied
by
bacterial
translocation,
severe
tissue
damage,
inflammation
dysbiosis
predictive
metabolic
shifts.
Furthermore,
body
weight
loss
lethality
experimental
colitis
model.
Recovery
physiological
restores
barrier
integrity,
while
microbiome
their
capabilities
not
fully
restituted.
Our
findings
uncover
previously
unrecognized
role
as
master
regulator
metabolism
challenge
current
paradigm
key
regulating
homeostasis.
One-Sentence
Summary
IgM,
most
immunoglobulin
jawed
vertebrates,
for
successful
symbiosis
microbiota.
Fish & Shellfish Immunology,
Journal Year:
2024,
Volume and Issue:
150, P. 109625 - 109625
Published: May 12, 2024
The
mucosal
surfaces
of
fish,
including
their
intestines,
gills,
and
skin,
are
constantly
exposed
to
various
environmental
threats,
such
as
water
quality
fluctuations,
pollutants,
pathogens.
However,
cells
microbiota
closely
associated
with
these
work
in
tandem
create
a
functional
protective
barrier
against
conditions.
Recent
research
has
shown
that
incorporating
specific
feed
ingredients
into
fish
diets
can
significantly
boost
general
immune
response.
Among
the
being
investigated,
insect
meal
emerged
one
most
promising
options,
owing
its
high
protein
content
immunomodulatory
properties.
By
positively
influencing
structure
function
surfaces,
potential
enhance
overall
status
fish.
This
review
provides
comprehensive
overview
benefits
aquafeed
ingredient
for
augmenting
response
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: Nov. 16, 2021
The
zebrafish
is
extensively
used
as
an
animal
model
for
human
and
fish
diseases.
However,
our
understanding
of
the
structural
organization
its
immune
system
remains
incomplete,
especially
mucosa-associated
lymphoid
tissues
(MALTs).
Teleost
MALTs
are
commonly
perceived
diffuse
scattered
populations
cells
throughout
mucosa.
Yet,
structured
have
been
recently
discovered
in
Atlantic
salmon
(Salmo
salar
L.),
including
interbranchial
tissue
(ILT)
gills.
existence
ILT
was
only
identified
other
species,
highlighting
need
in-depth
characterizations
gill-associated
(GIALT)
teleosts.
Here,
using
3-D
high-resolution
microscopy,
we
analyze
GIALT
adult
with
immuno-histology
approach
that
reveals
via
labeling
T/NK
antibody
directed
to
a
highly
conserved
epitope
on
kinase
ZAP70.
We
show
distributed
over
at
least
five
distinct
sub-regions,
found
all
pairs
gill
arches.
pharyngeal
part
arch,
septum
filaments/lamellae,
two
sub-regions:
ILT,
newly
structure
located
along
each
side
which
named
Amphibranchial
Lymphoid
Tissue
(ALT).
Based
RAG2
expression,
neither
nor
ALT
constitute
additional
thymi.
shares
several
features
such
presence
abundant
myeloid
embedded
network
reticulated
epithelial
cells.
Further,
also
site
cell
proliferation.
Both
changes
after
infection
Spring
Viraemia
Carp
Virus
(SVCV).
Together,
these
data
suggest
play
active
role
responses.
Comparative
studies
whereas
seems
absent
most
neoteleosts
("Percomorphs"),
widely
present
cyprinids,
salmonids
neoteleosts,
suggesting
it
constitutes
involved
protection
teleosts
