Successful
neurogenesis
requires
adequate
proliferation
of
neural
stem
cells
(NSCs)
and
their
progeny,
followed
by
neuronal
differentiation,
maturation
survival.
NSCs
inhabit
a
complex
cellular
microenvironment,
the
niche,
which
influences
behaviour.
To
ensure
sustained
neurogenesis,
niche
must
respond
to
extrinsic,
environmental
changes
whilst
fulfilling
intrinsic
requirements
neurogenic
program
adapting
roles
accordingly.
However,
very
little
is
known
about
how
different
adjust
properties
such
inputs.
Here,
we
show
that
nutritional
NSC-derived
signals
induce
remodelling
Drosophila
cortex
glia,
this
glial
evolving
needs
NSCs.
First,
nutrition-induced
activation
PI3K/Akt
drives
glia
expand
membrane
processes.
Second,
when
emerge
from
quiescence
resume
proliferation,
they
signal
promote
formation
bespoke
structure
around
each
NSC
lineage.
The
remodelled
essential
for
newborn
neuron
Neural Regeneration Research,
Journal Year:
2024,
Volume and Issue:
20(5), P. 1350 - 1363
Published: June 3, 2024
The
sleep-wake
cycle
stands
as
an
integrative
process
essential
for
sustaining
optimal
brain
function
and,
either
directly
or
indirectly,
overall
body
health,
encompassing
metabolic
and
cardiovascular
well-being.
Given
the
heightened
activity
of
brain,
there
exists
a
considerable
demand
nutrients
in
comparison
to
other
organs.
Among
these,
branched-chain
amino
acids,
comprising
leucine,
isoleucine,
valine,
display
distinctive
significance,
from
their
contribution
protein
structure
involvement
metabolism,
especially
cerebral
processes.
first
acids
that
are
released
into
circulation
post-food
intake,
assume
pivotal
role
regulation
synthesis,
modulating
insulin
secretion
acid
sensing
pathway
target
rapamycin.
Branched-chain
key
players
influencing
brain’s
uptake
monoamine
precursors,
competing
shared
transporter.
Beyond
these
contribute
cycles
γ-aminobutyric
glutamate,
well
energy
metabolism.
Notably,
they
impact
GABAergic
neurons
excitation/inhibition
balance.
rhythmicity
plasma
concentrations,
observed
over
24-hour
conserved
rodent
models,
is
under
circadian
clock
control.
mechanisms
underlying
those
rhythms
physiological
consequences
disruption
not
fully
understood.
Disturbed
sleep,
obesity,
diabetes,
diseases
can
elevate
concentrations
modify
oscillatory
dynamics.
driving
effects
currently
focal
point
ongoing
research
efforts,
since
normalizing
levels
has
ability
alleviate
severity
pathologies.
In
this
context,
Drosophila
model,
though
underutilized,
holds
promise
shedding
new
light
on
mechanisms.
Initial
findings
indicate
its
potential
introduce
novel
concepts,
particularly
elucidating
intricate
connections
between
clock,
sleep/wake,
Consequently,
use
transport
emerge
critical
components
orchestrators
web
interactions
across
multiple
organs
throughout
sleep/wake
cycle.
They
could
represent
one
so
far
elusive
connecting
sleep
patterns
paving
way
therapeutic
interventions.
Scientific Reports,
Journal Year:
2017,
Volume and Issue:
7(1)
Published: Feb. 20, 2017
Abstract
While
calcium
signaling
in
excitable
cells,
such
as
muscle
or
neurons,
is
extensively
characterized,
epithelial
tissues
little
understood.
Specifically,
the
range
of
intercellular
patterns
elicited
by
tightly
coupled
cells
and
their
function
regulation
characteristics
are
explored.
We
found
that
Drosophila
imaginal
discs,
a
widely
studied
model
organ,
complex
spatiotemporal
dynamics
occur.
describe
include
waves
traversing
large
tissue
domains
striking
oscillatory
well
spikes
confined
to
local
neighboring
cells.
The
oscillations
arise
emergent
properties
mobilization
within
sheet
gap-junction
influenced
cell
size
environmental
history.
vivo
spikes,
requires
further
characterization,
our
genetic
experiments
suggest
core
components
guide
actomyosin
organization.
Our
study
thus
suggests
possible
role
for
epithelia
but
importantly,
introduces
epithelium
enabling
dissection
cellular
mechanisms
supporting
initiation,
transmission
regeneration
long-range
emergence
highly
multicellular
sheet.
Successful
neurogenesis
requires
adequate
proliferation
of
neural
stem
cells
(NSCs)
and
their
progeny,
followed
by
neuronal
differentiation,
maturation
survival.
NSCs
inhabit
a
complex
cellular
microenvironment,
the
niche,
which
influences
behaviour.
To
ensure
sustained
neurogenesis,
niche
must
respond
to
extrinsic,
environmental
changes
whilst
fulfilling
intrinsic
requirements
neurogenic
program
adapting
roles
accordingly.
However,
very
little
is
known
about
how
different
adjust
properties
such
inputs.
Here,
we
show
that
nutritional
NSC-derived
signals
induce
remodelling
Drosophila
cortex
glia,
this
glial
evolving
needs
NSCs.
First,
nutrition-induced
activation
PI3K/Akt
drives
glia
expand
membrane
processes.
Second,
when
emerge
from
quiescence
resume
proliferation,
they
signal
promote
formation
bespoke
structure
around
each
NSC
lineage.
The
remodelled
essential
for
newborn
neuron
