The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Journal Year: 2023, Volume and Issue: 41(3), P. 374 - 403

Published: March 1, 2023

Language: Английский

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The matrix in cancer

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(4), P. 217 - 238

Published: Feb. 15, 2021

Language: Английский

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The metabolism of cancer cells during metastasis

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(3), P. 162 - 180

Published: Jan. 18, 2021

Language: Английский

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The dormant cancer cell life cycle

Nature reviews. Cancer, Journal Year: 2020, Volume and Issue: 20(7), P. 398 - 411

Published: June 2, 2020

Language: Английский

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Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

Cell, Journal Year: 2022, Volume and Issue: 185(3), P. 563 - 575.e11

Published: Feb. 1, 2022

Language: Английский

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Metastasis

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

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Metastasis-Initiating Cells and Ecosystems

Cancer Discovery, Journal Year: 2021, Volume and Issue: 11(4), P. 971 - 994

Published: April 1, 2021

Abstract Metastasis is initiated and sustained through therapy by cancer cells with stem-like immune-evasive properties, termed metastasis-initiating (MIC). Recent progress suggests that MICs result from the adoption of a normal regenerative progenitor phenotype malignant cells, intrinsic programs to survive stresses metastatic process, undergo epithelial–mesenchymal transitions, enter slow-cycling states for dormancy, evade immune surveillance, establish supportive interactions organ-specific niches, co-opt systemic factors growth recurrence after therapy. Mechanistic understanding molecular mediators MIC phenotypes host tissue ecosystems could yield therapeutics improve patient outcomes. Significance: Understanding origins, traits, vulnerabilities capacity initiate metastasis in distant organs, microenvironments support ability these surveillance regenerate tumor, critical developing strategies prevention treatment advanced cancer. Leveraging recent our here we review nature their offer perspective on how this knowledge informing innovative treatments cancers.

Language: Английский

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Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Molecular Therapy, Journal Year: 2022, Volume and Issue: 30(10), P. 3133 - 3154

Published: April 9, 2022

Exosomes have a crucial role in intercellular communication and mediate interactions between tumor cells tumor-associated macrophages (TAMs). Exosome-encapsulated non-coding RNAs (ncRNAs) are involved various physiological processes. Tumor-derived exosomal ncRNAs induce M2 macrophage polarization through signaling pathway activation, signal transduction, transcriptional post-transcriptional regulation. Conversely, TAM-derived promote proliferation, metastasis, angiogenesis, chemoresistance, immunosuppression. MicroRNAs gene silencing by directly targeting mRNAs, whereas lncRNAs circRNAs act as miRNA sponges to indirectly regulate protein expressions. The of tumor-host is ubiquitous. Current research increasingly focused on the microenvironment. On basis "cancer-immunity cycle" hypothesis, we discuss effects immune T cell exhaustion, overexpression programmed death ligands, create immunosuppressive Furthermore, potential applications prospects clinical biomarkers drug delivery systems. 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Language: Английский

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Revealing the transcriptional heterogeneity of organ‐specific metastasis in human gastric cancer using single‐cell RNA Sequencing

Clinical and Translational Medicine, Journal Year: 2022, Volume and Issue: 12(2)

Published: Feb. 1, 2022

Abstract Background Deciphering intra‐ and inter‐tumoural heterogeneity is essential for understanding the biology of gastric cancer (GC) its metastasis identifying effective therapeutic targets. However, characteristics different organ‐tropism metastases GC are largely unknown. Methods Ten fresh human tissue samples from six patients, including primary tumour adjacent non‐tumoural organs or tissues (liver, peritoneum, ovary, lymph node) were evaluated using single‐cell RNA sequencing. Validation experiments performed histological assays bulk transcriptomic datasets. Results Malignant epithelial subclusters associated with invasion features, intraperitoneal propensity, epithelial–mesenchymal transition‐induced stem cell phenotypes, dormancy‐like discovered. High expression first three subcluster‐associated genes displayed worse overall survival than those low in a cohort containing 407 samples. Immune stromal cells exhibited cellular created pro‐tumoural immunosuppressive microenvironment. Furthermore, 20‐gene signature node‐derived exhausted CD8 + T was acquired to forecast node validated cohorts. Additionally, although anti‐NKG2A (KLRC1) antibody have not been used treat patients even clinical trials, we uncovered only malignant but one endothelial subcluster, mucosal‐associated invariant cells, cell‐like B plasmacytoid dendritic macrophages, monocytes, neutrophils may contribute HLA‐E‐KLRC1/KLRC2 interaction cytotoxic/exhausted and/or natural killer (NK) suggesting novel opportunities GC. our findings suggested that PD‐1 might predict responses blockade therapy Conclusions This study provided insights into heterogeneous microenvironment tumours organ‐specific provide support precise diagnosis treatment.

Language: Английский

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Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

Nature Materials, Journal Year: 2020, Volume and Issue: 20(2), P. 156 - 169

Published: Aug. 17, 2020

Language: Английский

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