Current Medicine,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: April 15, 2024
Abstract
Mitochondria
serve
as
the
primary
site
for
metabolizing
three
major
nutrients,
underscoring
their
pivotal
role
in
cellular
energy
metabolism
and
regulation
of
signaling
pathways.
Mitochondrial
homeostatic
imbalance
is
a
key
pathological
cause
development
many
diseases.
Hence,
preserving
mitochondrial
homeostasis
vital
normal
growth
cells
organisms.
Living
organisms
have
evolved
intricate
regulatory
mechanisms
to
ensure
homeostasis.
This
review
focuses
on
recent
advancements
comprehending
responsible
maintaining
addresses
current
challenges
this
field.
We
also
provide
an
overview
functions
mitochondria
both
physiological
conditions.
Emphasizing
potential
therapeutic
implications,
we
discuss
strategies
homeostasis,
recognizing
its
significance
mitigating
various
health
Graphical
npj Metabolic Health and Disease,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: Jan. 13, 2025
Abstract
Metabolic
shifts
are
a
hallmark
of
numerous
biological
processes,
including
the
differentiation
stem
cells
along
specific
lineage
and
activation
diverse
cell
types,
such
as
immune
cells.
This
review
examines
intricate
energy
metabolic
alterations
that
occur
in
settings,
from
embryonic
development
to
adult
tissue
homoeostasis
disease
states.
In
particular,
we
emphasise
regulatory
function
RNA-binding
proteins
(RBPs)
coordinating
these
examine
how
they
modulate
key
pathways,
glycolysis
oxidative
phosphorylation,
meet
dynamic
cellular
demands.
highlights
various
mechanisms
by
which
RBPs
regulate
changes,
ranging
active
involvement
post-transcriptional
regulation
metabolically
relevant
genes
alteration
an
RBP’s
RNAs,
metabolites
or
growth
factors.
Finally,
consider
ageing
affect
can
disrupt
delicate
balance
regulation.
Taken
together,
this
provides
comprehensive
overview
critical
interplay
between
metabolism
offers
insights
into
potential
therapeutic
targets
for
regenerative
medicine
age-related
diseases.
Cell Regeneration,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: April 10, 2025
Abstract
Autophagy
is
a
crucial
cellular
process
that
facilitates
the
degradation
of
damaged
organelles
and
protein
aggregates,
recycling
components
for
energy
production
macromolecule
synthesis.
It
plays
an
indispensable
role
in
maintaining
homeostasis.
Over
recent
decades,
research
has
increasingly
focused
on
autophagy
regulating
adult
stem
cells
(SCs).
Studies
suggest
modulates
various
processes
states
SCs,
including
quiescence,
proliferation,
self-renewal,
differentiation.
The
primary
these
contexts
to
sustain
homeostasis,
withstand
stressors,
supply
energy.
Notably,
dysfunction
SCs
during
aging
correlated
with
decline
autophagic
activity,
suggesting
also
involved
SC-
aging-associated
disorders.
Given
diverse
mediated
by
intricate
mechanisms
governing
further
essential
elucidate
both
universal
cell
type-specific
regulatory
pathways
autophagy.
This
review
discusses
Additionally,
it
summarizes
relationship
between
SC
autophagy,
providing
therapeutical
insights
into
treating
ameliorating
diseases
cancers,
ultimately
promoting
longevity.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Summary
Microglia,
the
brain’s
immune
cells,
are
highly
responsive
to
their
local
environment.
Given
that
circulatory
proteins
can
enter
brain,
we
asked
whether
microglia
such
proteins.
Here,
identify
a
stable
population
of
specialized
take
up
in
region-specific
manner
under
physiological
conditions;
human
hematopoietic
stem
cell-derived
replacing
endogenous
chimeric
mice
show
similar
regional
specialization.
Plasma-positive
characterized
by
prominent
expression
genes
related
innate
immunity
and
antigen
presentation
exhibit
high
metabolic
phagocytic
activity.
This
activity
is
dependent,
part,
on
microglial
uptake
accumulation
Apolipoprotein
AI
(ApoA-I).
Our
findings
thus
new
model
communication
between
brain
periphery
through
microglia.
Cells,
Journal Year:
2024,
Volume and Issue:
13(21), P. 1773 - 1773
Published: Oct. 26, 2024
From
quiescence
to
activation
and
myogenic
differentiation,
muscle
stem
cells
(MuSCs)
experience
drastic
alterations
in
their
signaling
activity
metabolism.
Through
balanced
cycles
of
fission
fusion,
mitochondria
alter
morphology
metabolism,
allowing
them
affect
decisive
role
modulating
MuSC
fate
decisions.
This
tightly
regulated
process
contributes
regulation
by
mediating
changes
redox
pathways,
cell
cycle
progression,
In
this
review,
we
discuss
the
mitochondrial
dynamics
as
an
integral
modulator
activity,
fate,
maintenance.
Understanding
influence
MuSCs
health
disease
will
further
development
therapeutics
that
support
integrity
thus
may
aid
restoring
regenerative
capacity
skeletal
muscle.
STAR Protocols,
Journal Year:
2023,
Volume and Issue:
4(4), P. 102750 - 102750
Published: Dec. 1, 2023
Studying
skeletal
muscle
stem
cells
(MuSCs)
quiescence
is
challenging
as
they
quickly
activate
within
hours
of
isolation
from
muscle.
Here,
we
present
a
protocol
to
disassociate
and
characterize
fixed
peptides
quiescent
MuSCs
using
trapped
ion-mobility
time-of-flight
mass
spectrometry
(MS).
We
describe
steps
for
mouse
perfusion,
fluorescence-activated
cell
sorting
preparation
sorting,
protein
extraction,
digestion,
liquid
chromatography
MS
analysis.
This
can
be
applied
other
less-abundant
somatic
types
lines
with
reporter.
For
complete
details
on
the
use
execution
this
protocol,
please
refer
Zeng
et
al.
(2022,
2023).1,2
Journal of Cell Science,
Journal Year:
2024,
Volume and Issue:
137(15)
Published: July 22, 2024
Muscle
stem
cells
(MuSCs)
play
an
indispensable
role
in
postnatal
muscle
growth
and
hypertrophy
adults.
MuSCs
also
retain
a
highly
regenerative
capacity
are
therefore
considered
promising
cell
source
for
therapy
diseases.
In
this
study,
we
identify
tumor-suppressor
protein
Tob1
as
Pax7
target
that
negatively
controls
the
population
expansion
of
MuSCs.
is
undetectable
quiescent
state
but
upregulated
during
activation
ablation
mice
accelerates
MuSC
boosts
regeneration.
Moreover,
inactivation
ameliorates
efficiency
transplantation
murine
muscular
dystrophy
model.
Collectively,
selective
targeting
might
be
therapeutic
option
treatment
diseases,
including
age-related
sarcopenia.
Translational Cancer Research,
Journal Year:
2024,
Volume and Issue:
13(7), P. 3251 - 3261
Published: July 1, 2024
The
expression
level
of
early
growth
response
1
(EGR1)
is
elevated
in
colon
cancer
(CC)
tissues
and
closely
associated
with
poor
prognosis
colorectal
cancer.
However,
the
role
EGR1
as
a
transcription
factor
(TF)
influencing
cell
senescence
progression
CC
remains
largely
unexplored.
This
study
aims
to
investigate
impact
curcumin
on
by
modulating
EGR1.
