Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
252, P. 114630 - 114630
Published: Feb. 8, 2023
Rotenone,
a
widely
used
pesticide,
causes
dopaminergic
neurons
loss
and
increase
the
risk
of
Parkinson's
disease
(PD).
However,
few
studies
link
role
PARP1
to
neuroinflammatory
response
autophagy
dysfunction
in
rotenone-induced
neurodegeneration.
Here,
we
identified
that
overactivation
caused
by
rotenone
led
NLRP3-mediated
inflammation.
Further
results
showed
inhibition
could
reduce
inflammation,
which
was
effectively
eliminated
TFEB
knockdown.
Moreover,
poly(ADP-ribosyl)ated
reduced
autophagy.
Of
note,
rescue
loss.
Overall,
our
study
revealed
blocks
through
poly
(ADP-ribosyl)ating
inhibited
NLRP3
degradation,
suggests
intervention
PARP1-TFEB-NLRP3
signaling
can
be
new
treatment
strategy
for
Cells,
Journal Year:
2023,
Volume and Issue:
12(4), P. 659 - 659
Published: Feb. 19, 2023
Doxorubicin
(DOX)
constitutes
the
major
constituent
of
anti-cancer
treatment
regimens
currently
in
clinical
use.
However,
precise
mechanisms
DOX’s
action
are
not
fully
understood.
Emerging
evidence
points
to
pleiotropic
anticancer
activity
DOX,
including
its
contribution
DNA
damage,
reactive
oxygen
species
(ROS)
production,
apoptosis,
senescence,
autophagy,
ferroptosis,
and
pyroptosis
induction,
as
well
immunomodulatory
role.
This
review
aims
collect
information
on
DOX
influence
anti-tumor
immune
response,
providing
a
rationale
behind
importance
modern
cancer
therapy.
Proceedings of the National Academy of Sciences,
Journal Year:
2022,
Volume and Issue:
119(11)
Published: March 8, 2022
SignificancePARP
is
an
important
target
in
the
treatment
of
cancers,
particularly
patients
with
breast,
ovarian,
or
prostate
cancer
that
have
compromised
homologous
recombination
repair
(i.e.,
BRCA
Cancers,
Journal Year:
2022,
Volume and Issue:
14(17), P. 4162 - 4162
Published: Aug. 27, 2022
Poly(ADP-ribosyl)ation
(PARylation)
is
a
covalent
post-translational
modification
and
plays
key
role
in
the
immediate
response
of
cells
to
stress
signals.
Poly(ADP-ribose)
polymerase
1
(PARP1),
founding
member
PARP
superfamily,
synthesizes
long
branched
polymers
ADP-ribose
(PAR)
onto
acceptor
proteins,
thereby
modulating
their
function
local
surrounding.
PARP1
most
prominent
PARPs
responsible
for
production
about
90%
PAR
cell.
Therefore,
PARylation
play
pleotropic
wide
range
cellular
processes,
such
as
DNA
repair
genomic
stability,
cell
death,
chromatin
remodeling,
inflammatory
gene
transcription.
has
DNA-binding
catalytic
activities
that
are
important
repair,
yet
also
modulate
conformation
transcription,
which
can
be
independent
damage
response.
homeostasis
have
been
implicated
multiple
diseases,
including
inflammation,
stroke,
diabetes
cancer.
Studies
molecular
action
biological
provide
basis
development
pharmaceutic
strategies
clinical
applications.
This
review
focuses
primarily
on
regulation
remodeling
transcriptional
activation.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(19), P. 11068 - 11068
Published: Sept. 21, 2022
Proteolysis-targeting
chimeras
(PROTACs)
are
molecules
that
selectively
degrade
a
protein
of
interest
(POI).
The
incorporation
ligands
recruit
mouse
double
minute
2
(MDM2)
into
PROTACs,
forming
the
so-called
MDM2-based
has
shown
promise
in
cancer
treatment
due
to
its
dual
mechanism
action:
PROTAC
recruits
MDM2
prevents
binding
p53,
resulting
not
only
degradation
POI
but
also
increase
intracellular
levels
p53
suppressor,
with
activation
whole
set
biological
processes,
such
as
cell
cycle
arrest
or
apoptosis.
In
addition,
these
certain
cases,
allow
for
target,
nanomolar
potency,
rapid
and
sustained
manner
over
time,
less
susceptibility
development
resistance
tolerance,
without
causing
changes
expression,
selectivity
including
respective
isoforms
mutations,
type,
overcoming
some
limitations
associated
use
inhibitors
same
therapeutic
target.
Therefore,
aim
this
review
is
analyze
discuss
characteristics
PROTACs
developed
oncogenic
proteins
understand
what
potential
they
have
future
anticancer
drugs.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(8), P. 1195 - 1195
Published: July 31, 2023
Poly(ADP-ribose)
(PAR)
Polymerase
1
(PARP-1),
also
known
as
ADP-ribosyl
transferase
with
diphtheria
toxin
homology
(ARTD-1),
is
a
critical
player
in
DNA
damage
repair,
during
which
it
catalyzes
the
ADP
ribosylation
of
self
and
target
enzymes.
While
nuclear
localization
PARP-1
has
been
well
established,
recent
studies
suggest
its
mitochondrial
localization.
In
this
review,
we
summarize
differences
between
Base
Excision
Repair
(BER)
pathways,
involvement
BER,
functional
interplay
other
BER
