Carbon Dot Based Carbon Nanoparticles as Potent Antimicrobial, Antiviral, and Anticancer Agents

ACS Omega, Journal Year: 2024, Volume and Issue: 9(9), P. 9849 - 9864

Published: Feb. 22, 2024

Antimicrobial and anticancer drugs are widely used due to increasing widespread infectious diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells, which one of the major causes mortality globally. Nevertheless, several developed resistance antibiotics a result genetic changes that have occurred over an extended period. Carbon-based materials, particularly carbon dots (C-dots), potential candidates for antibacterial nanomaterials their low toxicity, ease synthesis functionalization, high dispersibility in aqueous conditions, promising biocompatibility. In this Review, content is divided into four sections. The first section concentrates on C-dot structures, surface morphology. Following that, we summarize classifications preparation methods arc discharge, laser ablation, electrochemical oxidation, so on. antimicrobial applications C-dots antibacterial, antifungal, antiviral agents both vivo vitro discussed. Finally, thoroughly examined activity displayed C-dots.

Language: Английский

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Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 512 - 512

Published: Jan. 24, 2024

Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies reveal a link between accumulation induction. This interconnected relationship presents promising strategy, especially for addressing refractory cancers marked by drug tolerance. Harnessing toxicity iron clinical settings becomes crucial. Simultaneous targeting cuproptosis, exemplified combination sorafenib elesclomol-Cu, represents an intriguing approach. Strategies mitochondria further enhance precision approaches, providing hope improving treatment outcomes drug-resistant cancers. Moreover, chelators copper-lowering agents established therapeutic modalities exhibits synergy that holds promise augmentation anti-tumor efficacy malignancies. review elaborates on complex interplay underlying mechanisms, explores potential druggable targets both research settings.

Language: Английский

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Research progress of organic photothermal agents delivery and synergistic therapy systems

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113743 - 113743

Published: Jan. 5, 2024

Language: Английский

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Oxidative Stress and Age-Related Tumors

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1109 - 1109

Published: Sept. 13, 2024

Oxidative stress is the result of imbalance between reactive oxygen and nitrogen species (RONS), which are produced by several endogenous exogenous processes, antioxidant defenses consisting molecules that protect biological systems from free radical toxicity. a major factor in aging process, contributing to accumulation cellular damage over time. biomolecules, leads DNA alterations, lipid peroxidation, protein oxidation, mitochondrial dysfunction resulting senescence, immune system tissue dysfunctions, increased susceptibility age-related pathologies, such as inflammatory disorders, cardiovascular neurodegenerative diseases, diabetes, cancer. stress-driven mutations, or methylation histone modification, alter gene expression, key determinants tumor initiation, angiogenesis, metastasis, therapy resistance. Accumulation genetic epigenetic damage, oxidative contributes, eventually unrestrained cell proliferation, inhibition differentiation, evasion death, providing favorable conditions for tumorigenesis. Colorectal, breast, lung, prostate, skin cancers most frequent aging-associated malignancies, implicated their pathogenesis behavior. Our aim shed light on molecular mechanisms link stress, aging, cancers, highlighting impact both RONS antioxidants, provided diet exercise, immunity, development an antitumor response. The dual role ROS physiological regulators signaling responsible well its use anti-tumor therapeutic purposes, will also be discussed. Managing crucial promoting healthy reducing risk tumors.

Language: Английский

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Thirty years from FDA approval of pegylated liposomal doxorubicin (Doxil/Caelyx): an updated analysis and future perspective

BMJ Oncology, Journal Year: 2025, Volume and Issue: 4(1), P. e000573 - e000573

Published: Jan. 1, 2025

In 2025, it will be 30 years since the initial clinical approval of pegylated liposomal doxorubicin (PLD) by Food and Drug Administration. PLD predated field nanomedicine became a model setting key pharmacological principles (prolonged circulation, slow drug release enhanced permeability retention (EPR) effect) for application other nano-drugs in cancer therapy. The impressive reduction cardiotoxicity conferred is most valuable asset. While has gained strong foothold relapsed ovarian metastatic breast cancer, not been extensively tested primary (neoadjuvant) adjuvant therapy fulfilled expectations from results animal models efficacy-wise. This discrepancy may due to large dose gap between mice humans apparent variability EPR effect human cancer. complex product we are still learning curve regarding number factors such as its interaction with complement system immune modulatory properties, well integration multimodality that potentiate value role

Language: Английский

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Cyclodextrin-based nanocarriers as promising scaffolds for overcoming challenges of doxorubicin delivery in cancer chemotherapy

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100677 - 100677

Published: Jan. 1, 2025

Language: Английский

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DNA dendrimer-based nanocarriers for targeted Co-delivery and controlled release of multiple chemotherapeutic drugs

RSC Advances, Journal Year: 2025, Volume and Issue: 15(4), P. 2981 - 2987

Published: Jan. 1, 2025

DNA-based nanomaterials have attracted increasing attention over the past decades due to their incomparable programmability and functionality. In particular, dendritic DNA nanostructures are ideal for constructing drug carriers highly branched structure. this study, an intelligent delivery system was constructed based on dendrimers, in which duplexes were utilized simultaneously loading both hydrophilic hydrophobic small molecule drugs. Additionally, cancer microenvironment-responsive cell-targeting moieties introduced into internal framework surface of nanostructures, respectively. Our research shows that these can enter cells through endocytosis disintegrate under reduction cellular glutathione, thereby achieving targeted co-delivery controlled release chemotherapeutic agents antisense oligonucleotides, providing effective strategy combined treatment tumors.

Language: Английский

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In Vitro Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: Jan. 1, 2025

Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. This study aimed to evaluate the potentiation of against MCF-7 cancer cell line encapsulating both CAM in PEGylated liposomes. liposomes containing were prepared using thin film hydration method. The physicochemical properties liposomes, average particle size, polydispersity index (PDI), zeta potential, characterized. Encapsulation efficiencies assessed, stability was evaluated over 9 days at room temperature. Cell viability measured an IC50 assay, P-gp expression levels determined ELISA. CAM/DOX-PEGylated exhibited optimal size (238 ± 26.7 nm), PDI (0.29 0.107), potential (-20.9 2.17 mV). These maintained good regarding charge days. 81.05% 78.13% DOX. value 0.13 µM, representing significant reduction compared physical mixture (0.25 µM) free (0.21 cells. ELISA analysis showed approximately 5% with 1.61% results indicate that encapsulated enhances cells, likely inhibition p-glycoprotein. approach may offer promising strategy overcome improve chemotherapy outcomes.

Language: Английский

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Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

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Current Advances in the Therapeutic Potential of Scutellarin: Novel Applications, Mechanisms, and Future Challenges.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100754 - 100754

Published: Jan. 1, 2025

Language: Английский

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