RNA polymerase collisions and their role in transcription

Transcription, Journal Year: 2024, Volume and Issue: 15(1-2), P. 38 - 47

Published: Feb. 15, 2024

RNA polymerases are the central enzymes of gene expression and function frequently in either a head-on or co-directional manner on busy DNA track. Whether how these collisions between contribute to transcriptional regulation is mysterious. Increasing evidence from biochemical single-molecule studies suggests that polymerase as an important regulator fine-tune transcription, rather than creating deleterious "traffic jams". This review summarizes recent progress elucidating consequences during transcription highlights significance cooperation coordination polymerases.

Language: Английский

Single-molecule fluorescence imaging of DNA maintenance protein binding dynamics and activities on extended DNA

Current Opinion in Structural Biology, Journal Year: 2024, Volume and Issue: 87, P. 102863 - 102863

Published: June 15, 2024

Language: Английский