Drug repurposing for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: April 18, 2024

Abstract Cancer, a complex and multifactorial disease, presents significant challenge to global health. Despite advances in surgical, radiotherapeutic immunological approaches, which have improved cancer treatment outcomes, drug therapy continues serve as key therapeutic strategy. However, the clinical efficacy of is often constrained by resistance severe toxic side effects, thus there remains critical need develop novel therapeutics. One promising strategy that has received widespread attention recent years repurposing: identification new applications for existing, clinically approved drugs. Drug repurposing possesses several inherent advantages context since repurposed drugs are typically cost-effective, proven be safe, can significantly expedite development process due their already established safety profiles. In light this, present review offers comprehensive overview various methods employed repurposing, specifically focusing on treat cancer. We describe antitumor properties candidate drugs, discuss detail how they target both hallmarks tumor cells surrounding microenvironment. addition, we examine innovative integrating with nanotechnology enhance topical delivery. also emphasize role play when used part combination regimen. To conclude, outline challenges associated consider future prospects these transitioning into application.

Language: Английский

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Metabolic memory: mechanisms and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 28, 2024

Metabolic diseases and their complications impose health economic burdens worldwide. Evidence from past experimental studies clinical trials suggests our body may have the ability to remember metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading chronic inflammatory disorders other even after elimination of these environments. The long-term effects that aberrant metabolism on been summarized memory are found assume a crucial role in states disease. Multiple molecular mechanisms collectively participate management, resulting different cellular alterations well tissue organ dysfunctions, culminating disease progression affecting offspring. elucidation expansion concept provides more comprehensive insight into pathogenic underlying promises be new target detection management. Here, we retrace history relevant research summarize its salient characteristics. We provide detailed discussion by which involved development at molecular, cellular, levels, with emphasis impact epigenetic modulations. Finally, present some pivotal findings arguing favor targeting develop therapeutic strategies for latest reflections consequences implications human diseases.

Language: Английский

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Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3826 - 3826

Published: July 27, 2023

Colorectal cancer (CRC) poses a significant challenge in healthcare, necessitating the exploration of novel therapeutic strategies. Natural compounds such as polyphenols with inherent anticancer properties have gained attention potential agents. This review highlights need for approaches CRC, followed by discussion on synthesis polyphenols-based nanoparticles. Various techniques, including dynamic covalent bonding, non-covalent polymerization, chemical conjugation, reduction, and metal-polyphenol networks, are explored. The mechanisms action these nanoparticles, encompassing passive active targeting mechanisms, also discussed. further examines intrinsic activity their enhancement through nano-based delivery systems. section explores natural investigates different systems, micelles, nanogels, liposomes, nanoemulsions, gold mesoporous silica metal–organic frameworks. concludes emphasizing nanoparticle-based strategies utilizing CRC treatment future research to optimize efficacy safety. Overall, this provides valuable insights into synthesis, action, activity, nanoparticles treatment.

Language: Английский

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Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 17(1), P. 12 - 12

Published: Dec. 21, 2023

Repurposing drugs by uncovering new indications for approved accelerates the process of establishing treatments and reduces high costs drug discovery development. Metal complexes with clinically allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes a suitable metal to complex therapeutic drugs, potentially improving their efficacy treatment. In this review, covering last 25 years research field, we identified non-oncology-approved as ligands obtain different complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) non-steroidal anti-inflammatory cetirizine imidazole-based oxidovanadium(IV) complexes, each has parent known medicinal properties indications, all showed potential novel anticancer treatments. Nevertheless, precise mechanisms action these against are still not fully understood.

Language: Английский

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Repurposing of Antifungal Drug Flucytosine/Flucytosine Cocrystals for Anticancer Activity against Prostate Cancer Targeting Apoptosis and Inflammatory Signaling Pathways

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(5), P. 2577 - 2589

Published: April 22, 2024

This study aimed to repurpose the antifungal drug flucytosine (FCN) for anticancer activity together with cocrystals of nutraceutical coformers sinapic acid (SNP) and syringic (SYA). The cocrystal screening experiments SNP resulted in three hydrate forms which two are polymorphs, namely, FCN-SNP F-I F-II, third one different stoichiometry asymmetric unit (1:2:1 ratio FCN:SNP:H

Language: Английский

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Machine Learning Applications for Drug Repurposing

Published: June 19, 2024

Machine learning (ML) is revolutionizing drug repurposing, offering a more efficient, cost-effective approach to discovery by identifying new therapeutic uses for existing drugs. ML algorithms process large, complex biomedical datasets, find hidden patterns that reveal unexpected links between drugs and diseases, predict potential side effects. This advancement holds significant promise precision medicine personalized healthcare. chapter aims explore the growing role of in an emergent frontier identify drugs, thereby accelerating pace medical innovation while mitigating cost risk. The discusses various case studies, demonstrating application drug–disease connections predicting adverse reactions, significantly contributing medicine. In addition, investigates successes challenges encountered this nascent field, highlighting modernize discovery. Emphasis placed on ethical privacy concerns surrounding use patient data models, urging need robust regulations. comprehensive review serves as practical guide those at intersection pharmaceutical research, clinical practice, computer sciences, advocating synergetic these fields advancing

Language: Английский

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Ramipril, perindopril and trandolapril as potential chemosensitizers in ovarian cancer: considerations for drug repurposing

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104331 - 104331

Published: March 1, 2025

Language: Английский

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Identification of Imidazo[1,2-a]pyridine-3-amine as a Novel Drug-like Scaffold for Efficious Ferroptosis Inhibition in vivo

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117516 - 117516

Published: March 1, 2025

Language: Английский

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Synergistic strategies for cancer treatment: leveraging natural products, drug repurposing and molecular targets for integrated therapy

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 30, 2024

Abstract Background Uncontrolled cell proliferation is a major cause of cancer development and progression. Inflammation along with inflammatory mediators cells play significant role in cancer. Cancer ranks second mortality rates, following cardiac diseases. Phytochemicals from medicinal plants offer natural effective approach for treating Main body the abstract Animal studies provide evidence that phytochemicals present food acts as antioxidants, anti-aging molecules, health promoters, thereby extending lifespan. These compounds include quercetin, epicatechin, resveratrol, curcumin, kaempferol, vitamin C carotenoids. However, clinical data on humans still awaited. Conventional allopathic therapies often have severe side effects. Recently, drug repurposing has emerged an alternative strategy offering lower costs, shorter times advantage existing data. The primary goal to discover new uses approved or experimental drugs. Short conclusion current review elucidates effects synthetic drugs beneficial non-oncological their mechanisms action Additionally, it highlights trial various cancers focusing molecular targets. By integrating products, targets, we can develop multifaceted maximize efficacy minimize adverse This integrated promises more personalized treatments, improving patient outcomes quality life. Future research should identifying novel compounds, explore opportunities drugs, elucidate targets precise therapy. trials be conducted validate safety these combined strategies patients. Graphical

Language: Английский

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The Arylamine N-Acetyltransferases as Therapeutic Targets in Metabolic Diseases Associated with Mitochondrial Dysfunction

Pharmacological Reviews, Journal Year: 2023, Volume and Issue: 76(2), P. 300 - 320

Published: Dec. 7, 2023

In humans, there are two arylamine N-acetyltransferase genes that encode functional enzymes (NAT1 and NAT2) as well one pseudogene, all of which located together on chromosome 8. While they were first identified by their role in the acetylation drugs other xenobiotics, recent studies have shown strong associations for both a variety diseases including cancer, cardiovascular disease, diabetes. There is growing evidence this association may be causal. Consistently, NAT1 NAT2 to required healthy mitochondrial. This review discusses current literature mitochondrial bioenergetics. It will attempt relate our understanding evolution with biological function then present several major metabolic influenced NAT2. Finally, it discuss future approaches inhibit or enhance activity/expression using small molecule drugs. Significance Statement The N-acetyltransferases, NAT2, share common features Together, potential drug targets where dysfunction hallmark onset progression.

Language: Английский

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