Nanomedicine
is
revolutionizing
precision
medicine,
providing
targeted,
personalized
treatment
options.
Lipid-based
nanomedicines
offer
distinct
benefits
including
high
potency,
targeted
delivery,
extended
retention
in
the
body,
reduced
toxicity,
and
lower
required
doses.
These
characteristics
make
lipid-based
nanoparticles
ideal
for
drug
delivery
areas
such
as
gene
therapy,
cancer
treatment,
mRNA
vaccines.
However,
traditional
bulk
synthesis
methods
LNPs
often
produce
larger
particle
sizes,
significant
polydispersity,
low
encapsulation
efficiency,
which
can
reduce
therapeutic
effectiveness.
issues
primarily
result
from
uneven
mixing
limited
control
over
formation
during
synthesis.
Microfluidic
technology
has
emerged
a
solution,
precise
size,
uniformity,
efficiency.
In
this
mini
review,
we
introduce
state-of-the-art
microfluidic
systems
nanoparticle
functionalization.
We
include
working
principles
of
different
types
systems,
use
LNP
synthesis,
cargo
encapsulation,
nanomedicine
delivery.
end,
briefly
discuss
clinical
enabled
by
devices.
Langmuir,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Liposomes
are
highly
beneficial
nanocarrier
systems
due
to
their
biocompatibility,
low
toxicity,
and
exceptional
inclusiveness,
which
lead
improved
drug
bioavailability.
For
biological
applications,
accurate
control
over
these
nanoparticles'
mean
size
distribution
is
essential.
Micromixers
facilitate
the
continuous
production
of
liposomes,
enhancing
precision
regulation
reproducibility.
In
this
research,
performance
a
stainless
steel
316L
micromixer
was
evaluated
by
using
COMSOL
Multiphysics
simulations.
The
liposomes
were
precisely
optimized
design
experiments
techniques
in
microfluidic
setup,
then
dexamethasone
sodium
phosphate
(DSP)
successfully
encapsulated
liposome
nanoparticles.
physicochemical
characteristics
such
as
ζ-potential,
size,
DSP
loading
capacity,
encapsulation
efficiency,
release,
assessed.
Transmission
electron
microscopy
dynamic
light
scattering
analysis
used
examine
structures
liposomes.
release
kinetics
study
conducted
analyze
delivery
system,
Higuchi
equation
determined
be
most
suitable
equation.
chip
shown
capable
creating
small-sized
with
small
130
nm,
exhibiting
monodispersed
polydispersity
populations.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
17(2)
Published: March 1, 2025
ABSTRACT
The
field
of
nanomedicine
offers
revolutionary
potential
to
reshape
the
discovery
and
development
therapeutics
for
diverse
human
diseases.
However,
its
application
has
been
limited
in
improving
Substance
Use
Disorders
(SUDs),
which
represent
a
profound
public
health
crisis,
including
major
types
such
as
opioid,
alcohol,
stimulant,
cannabis
use
disorders.
Pharmacotherapy,
cornerstone
SUD
management,
reduced
morbidity,
mortality,
societal
impact
addiction,
though
efficacy
ranged
from
none
moderate.
Thus,
there
is
unmet
need
transform
pharmacotherapy
curb
epidemic
addiction.
This
article
explores
roles
nanomedicine‐inspired
precision‐targeted
drug
delivery,
sustained
release,
combination
therapies
increase
therapeutic
minimize
side
effects.
Additionally,
it
discusses
innovative
mechanisms
that
align
with
neurobiological
complexities
addiction
synergistic
approaches
integrate
behavioral
interventions,
device‐based
therapies,
emerging
modalities
immunotherapy
neurostimulation.
Despite
these
advancements,
barriers
treatment
accessibility,
adherence
challenges,
inequitable
resource
distribution
persist,
particularly
underserved
populations.
By
harnessing
transformative
capabilities
integrating
into
holistic,
equitable,
personalized
care
frameworks,
this
review
highlights
path
forward
revolutionize
landscape.
underscores
continued
nano‐SUD
research
strategies
alleviate
substantial
burden
on
individuals,
families,
society.
