Ferroptosis: Potential opportunities for natural products in cancer therapy DOI

Anzheng Nie,

Chaozan Shen,

Zheng Zhou

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(3), P. 1173 - 1190

Published: Dec. 20, 2023

Abstract Cancer cells often exhibit defects in the execution of cell death, resulting poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form programmed death characterized by intracellular iron overload and lipid peroxidation membrane. Increasing evidence suggests that ferroptosis closely associated wide variety physiological pathological processes, particularly cancer. Notably, various bioactive natural products have been shown to induce initiation cells, thereby exerting anticancer effects. In this review, we summarize core regulatory mechanisms multifaceted roles Importantly, focus on regulate such as terpenoids, polyphenols, alkaloids, steroids, quinones, polysaccharides. The efficacy, adverse effects, drug–drug interactions these need be evaluated further high‐quality studies accelerate their application treatment.

Language: Английский

Tumor-resident Malassezia can promote hepatocellular carcinoma development by downregulating bile acid synthesis and modulating tumor microenvironment DOI Creative Commons

Wei-Xi Shen,

Zhihong Li,

Lei Wang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 29, 2025

Language: Английский

Citations

0
A Novel Signature Composed of Hypoxia, Glycolysis, Lactylation Related Genes to Predict Prognosis and Immunotherapy in Hepatocellular Carcinoma DOI Creative Commons

Yi Feng,

Shichao Long,

Yuanbing Yao

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(4)

Published: April 21, 2025

Background: Hepatocellular carcinoma (HCC) is one of the leading causes cancer death worldwide. The hypoxic microenvironment in HCC enhances glycolysis and co-directed lactate accumulation, which leads to increased lactylation. However, exact biological pattern remains be elucidated. Therefore, we sought identify hypoxia-glycolysis-lactylation (HGL) prognosis-related signatures validate this vitro. Methods: Transcriptomic data patients with were collected from Cancer Genome Atlas (TCGA), International Consortium (ICGC), Gene Expression Omnibus (GEO) databases. Differentially expressed HGL genes between normal tissues obtained by DEseq2. consensus clustering algorithm was employed stratify into two distinct clusters. Subsequently, single sample Set Enrichment Analysis (ssGSEA), Tumor Immune Estimation Resource (TIMER) Dysfunction Exclusion (TIDE) algorithms utilized assess immune infiltration evasion. Least Absolute Shrinkage Selection Operator (LASSO) COX regression analysis used an signature. Based on spatial transcriptome histological data, analyzed expression these explored function Homer Scaffold Protein 1 (HOMER1) cells. Results: We identified 72 differentially Cluster2, better survival (p < 0.001), significantly enriched metabolic-related pathways. signature exhibited great predictive efficacy for TCGA, ICGC, GSE148355 databases (3-year area under curve (AUC) = 0.822, 0.738, 0.707, respectively). elevated HOMER1 revealed combination data. Knocking down inhibited malignant progression Conclusions: a discovered gene, HOMER1, that influences potential become novel therapeutic target.

Language: Английский

Citations

0
Increased expression of DNAJC7 promotes the progression of hepatocellular carcinoma by influencing the cell cycle and immune microenvironment DOI Creative Commons
Jiaxing Chen, Zhizhao Yang, Yongqiang Cui

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(5)

Published: May 2, 2025

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide owing to lack effective and early diagnostic tools therapeutic approaches. DNAJC7, a member DnaJ heat shock family, crucial in protein folding stability; however, its specific functions mechanisms HCC remain unclear. This study aimed explore role DNAJC7 progression evaluate potential clinical significance as prognostic marker. Public databases (TCGA, ICGC, GEO, TIMER) were used assess expression, correlations with parameters, related signaling pathways. Proliferation, migration, invasion, cell cycle assays performed function HCC. Immune infiltration associations checkpoint proteins analyzed using TIMER, Gene Set Enrichment Analysis (GSEA) was enriched expression higher tissues than adjacent normal associated advanced malignancy poor prognosis, including lower overall survival, progression-free disease-free survival. knockdown resulted reduced malignant behavior cells, S-phase arrest. Increased immune presence immunological molecules, CTLA4 PD-1. GSEA highlighted activation key pathways, WNT regulation. regulates tumor proliferation, evasion by acting an oncogene It can serve biomarker treatment target for

Language: Английский

Citations

0
Lenvatinib-activated NDUFA4L2/IL33/PADI4 pathway induces neutrophil extracellular traps that inhibit cuproptosis in hepatocellular carcinoma DOI Creative Commons

Nan Yi,

Lingyun Zhang,

Xiangbo Huang

et al.

Cellular Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Lenvatinib is a potent first-line therapy for patients with hepatocellular carcinoma (HCC), but it also increased the number of neutrophils in HCC tumor microenvironment. CitH3, MPO-DNA, elastase and MPO activity were measured assessing neutrophil extracellular traps (NETs) vivo vitro. Cell cuproptosis was assessed by measurement copper content, FDX1, pyruvate. The functions lenvatinib, DNase I, interleukin 33 (IL33) neutralizing antibody GPX4 growth explored mice. induced NETs microenvironment via cells, not through direct stimulation neutrophils. In addition, NET clearance I improves efficacy lenvatinib mouse models. Mechanistically, promoted expression secretion IL33 cells that triggered formation. Moreover, knockdown Hepa1-6 improved Hepa1-6-bearing model mice reduced formation Subsequently, production increasing NDUFA4L2 cells. Furthermore, we found protein PADI4 Akt/mTOR signaling pathway. Rapamycin inhibition mTOR Consistently, selective PAD4 inhibitor GSK484 hydrochloride (GSK484) response to therapy. Importantly, contribute resistance inhibiting cuproptosis, apoptosis, pyroptosis, or ferroptosis Treatment reversed inhibitory effects on sensitized lenvatinib. Our study revealed lenvatinib-induced inhibited suggesting targeting IL33/PADI4/NET axis represents promising therapeutic strategy ameliorating HCC.

Language: Английский

Citations

3
Ferroptosis: Potential opportunities for natural products in cancer therapy DOI

Anzheng Nie,

Chaozan Shen,

Zheng Zhou

et al.

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(3), P. 1173 - 1190

Published: Dec. 20, 2023

Abstract Cancer cells often exhibit defects in the execution of cell death, resulting poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form programmed death characterized by intracellular iron overload and lipid peroxidation membrane. Increasing evidence suggests that ferroptosis closely associated wide variety physiological pathological processes, particularly cancer. Notably, various bioactive natural products have been shown to induce initiation cells, thereby exerting anticancer effects. In this review, we summarize core regulatory mechanisms multifaceted roles Importantly, focus on regulate such as terpenoids, polyphenols, alkaloids, steroids, quinones, polysaccharides. The efficacy, adverse effects, drug–drug interactions these need be evaluated further high‐quality studies accelerate their application treatment.

Language: Английский

Citations

9