FERREG: ferroptosis-based regulation of disease occurrence, progression and therapeutic response DOI Creative Commons
Yuan Zhou, Zhen Chen,

Mengjie Yang

et al.

Briefings in Bioinformatics, Journal Year: 2024, Volume and Issue: 25(3)

Published: March 27, 2024

Ferroptosis is a non-apoptotic, iron-dependent regulatory form of cell death characterized by the accumulation intracellular reactive oxygen species. In recent years, large and growing body literature has investigated ferroptosis. Since ferroptosis associated with various physiological activities regulated variety cellular metabolism mitochondrial activity, been closely related to occurrence development many diseases, including cancer, aging, neurodegenerative ischemia-reperfusion injury other pathological death. The regulation mainly focuses on three pathways: system Xc-/GPX4 axis, lipid peroxidation iron metabolism. genes involved in these processes were divided into driver, suppressor marker. Importantly, small molecules or drugs that mediate expression are often good treatments clinic. Herein, newly developed database, named 'FERREG', documented (i) providing data ferroptosis-related diseases occurrence, progression drug response; (ii) explicitly describing molecular mechanisms underlying each regulation; (iii) fully referencing collected cross-linking them available databases. Collectively, FERREG contains 51 targets, 718 regulators, 445 158 disease responses. can be accessed at https://idrblab.org/ferreg/.

Language: Английский

The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions DOI Open Access
Guang Lei, Li Zhuang, Boyi Gan

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(4), P. 513 - 534

Published: April 1, 2024

Language: Английский

Citations

116
Engineering CAR-NK cell derived exosome disguised nano-bombs for enhanced HER2 positive breast cancer brain metastasis therapy DOI

Bolong Tao,

Ruoxin Du,

Xiangmei Zhang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 692 - 706

Published: Oct. 17, 2023

Language: Английский

Citations

44
Wood calamint ameliorates ethanol-induced stomach injury in rats by augmentation of hsp/bax and inflammatory mechanisms DOI
Khaled Abdul‐Aziz Ahmed, Ahmed Aj. Jabbar,

Mohammed M. Hussein M. Raouf

et al.

Journal of Molecular Histology, Journal Year: 2024, Volume and Issue: 55(4), P. 567 - 579

Published: June 18, 2024

Language: Английский

Citations

9
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity DOI Creative Commons
Zili Lin, Yusheng Li,

Ziyi Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 14, 2025

Language: Английский

Citations

1
Targeting ferroptosis in gastric cancer: Strategies and opportunities DOI

Jiahan Le,

Guangzhao Pan,

Che Zhang

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 321(1), P. 228 - 245

Published: Oct. 30, 2023

Summary Ferroptosis is a novel form of programmed cell death morphologically, genetically, and biochemically distinct from other pathways characterized by the accumulation iron‐dependent lipid peroxides oxidative damage. It now understood that ferroptosis plays an essential role in various biological processes, especially metabolism iron, lipids, amino acids. Gastric cancer (GC) prevalent malignant tumor worldwide with low early diagnosis rates high metastasis rates, accounting for its relatively poor prognosis. Although chemotherapy commonly used to treat GC, drug resistance often leads therapeutic outcomes. In last several years, extensive research on has highlighted significant potential GC therapy, providing promising strategy address associated standard therapies. this review, we offer summary key regulatory factors related mechanisms underlying ferroptosis. Various inducers inhibitors specifically targeting are uncovered. Additionally, explore prospective applications outcomes these agents field emphasizing their capacity improve patient population.

Language: Английский

Citations

21
The potential roles of HIF-1α in epithelial-mesenchymal transition and ferroptosis in tumor cells DOI Creative Commons

Zhongjun Shen,

Na Yu, Yanfeng Zhang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111345 - 111345

Published: Aug. 10, 2024

In tumors, the rapid proliferation of cells and imperfect blood supply system lead to hypoxia, which can regulate adaptation tumor hypoxic environment through hypoxia-inducible factor-1α (HIF-1α) promote development in multiple ways. Recent studies have found that epithelial-mesenchymal transition (EMT) ferroptosis play important roles progression cells. The activation HIF-1α is considered a key factor inducing EMT When activated, it EMT-related genes, causing gradually lose their epithelial characteristics acquire more invasive mesenchymal traits. occurrence allows better adapt changes surrounding tissue, enhancing migratory capabilities, thus promoting progression. At same time, also plays crucial regulatory role environment, may affect processes such as iron metabolism oxidative stress responses, This article briefly reviews dual cells, helping gain deeper understanding pathways providing new perspective for pathogenesis tumors. regulation become an strategy future therapy.

Language: Английский

Citations

8
Photo‐Activated Oxidative Stress Amplifier: A Strategy for Targeting Glutathione Metabolism and Enhancing ROS‐Mediated Therapy in Triple‐Negative Breast Cancer Treatment DOI
Li Zhao, Yao Tong, Jiawei Yin

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 3, 2024

Abstract Amplifying oxidative stress within tumor cells can effectively inhibit the growth and metastasis of triple‐negative breast cancer (TNBC). Therefore, development innovative nanomedicines that disrupt redox balance represents a promising yet challenging therapeutic strategy for TNBC. In this study, an amplifier, denoted as PBCH, comprising PdAg mesoporous nanozyme CaP mineralized layer, loaded with GSH inhibitor L‐buthionine sulfoximine (BSO), further surface‐modified hyaluronic acid target CD44, is introduced. acidic microenvironment, Ca 2+ initially released, thereby leading to mitochondrial dysfunction eventually triggering apoptosis. Additionally, BSO suppresses synthesis intracellular reduced amplifies level in cells. Furthermore, be activated by near‐infrared light induce photothermal photodynamic effects, causing burst ROS simultaneously promoting cell apoptosis via provoking immunogenic death. The high‐performance effects based on synergistic effect aforementioned multiple damage ablation, are validated TNBC animal models, declaring its potential safe effective anti‐tumor agent. proposed approach offers new perspectives precise efficient treatment

Language: Английский

Citations

7
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications DOI Creative Commons

Qiuyang Gu,

Yumei An,

Mingyuan Xu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Programmed cell death is pivotal for several physiological processes, including immune defense. Further, it has been implicated in the pathogenesis of developmental disorders and onset numerous diseases. Multiple modes programmed death, apoptosis, pyroptosis, necroptosis, ferroptosis, have identified, each with their own unique characteristics biological implications. In February 2023, Liu Xiaoguang his team discovered "disulfidptosis," a novel pathway death. Their findings demonstrated that disulfidptosis triggered glucose-starved cells exhibiting high expression protein called SLC7A11. Furthermore, marked by drastic imbalance NADPH/NADP+ ratio abnormal accumulation disulfides like cystine. These changes ultimately lead to destabilization F-actin network, causing Given SLC7A11 key feature certain cancers, these indicate could serve as basis innovative anti-cancer therapies. Hence, this review delves into discovery disulfidptosis, its underlying molecular mechanisms metabolic regulation, prospective applications disease treatment.

Language: Английский

Citations

6
New 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one derivatives as antimicrobial and anti-cancer agents: Synthesis, in-vitro and SAR studies DOI
Farid M. Sroor, Abdelmageed M. Othman, Khaled Mahmoud

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1294, P. 136516 - 136516

Published: Aug. 30, 2023

Language: Английский

Citations

14
Ferroptosis in lung cancer: dual role, multi-level regulation, and new therapeutic strategies DOI Creative Commons

Yunbin Li,

Xiaosong Li, Jian Li

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: March 7, 2024

Lung cancer is a highly prevalent malignant tumor worldwide, with high incidence and death rates. Recently, there has been increasing recognition of the role ferroptosis, unique cell mechanism, in lung cancer. This review aims to summarize current research progress on relationship between ferroptosis It also provides comprehensive analysis regulatory processes various stages, including epigenetics, transcription, post-transcription, translation, post-translation. Additionally, explores dual nature progression, which presents interesting therapeutic possibilities. On one hand, can promote escape immune surveillance reduce efficacy treatment early stages tumors. other it counter drug resistance, enhance radiosensitivity, immunotherapy. The article discusses combination strategies based mechanism ferroptosis. Overall, this offers holistic perspective onset, contribute future clinical interventions field.

Language: Английский

Citations

4