Briefings in Bioinformatics,
Journal Year:
2024,
Volume and Issue:
25(3)
Published: March 27, 2024
Ferroptosis
is
a
non-apoptotic,
iron-dependent
regulatory
form
of
cell
death
characterized
by
the
accumulation
intracellular
reactive
oxygen
species.
In
recent
years,
large
and
growing
body
literature
has
investigated
ferroptosis.
Since
ferroptosis
associated
with
various
physiological
activities
regulated
variety
cellular
metabolism
mitochondrial
activity,
been
closely
related
to
occurrence
development
many
diseases,
including
cancer,
aging,
neurodegenerative
ischemia-reperfusion
injury
other
pathological
death.
The
regulation
mainly
focuses
on
three
pathways:
system
Xc-/GPX4
axis,
lipid
peroxidation
iron
metabolism.
genes
involved
in
these
processes
were
divided
into
driver,
suppressor
marker.
Importantly,
small
molecules
or
drugs
that
mediate
expression
are
often
good
treatments
clinic.
Herein,
newly
developed
database,
named
'FERREG',
documented
(i)
providing
data
ferroptosis-related
diseases
occurrence,
progression
drug
response;
(ii)
explicitly
describing
molecular
mechanisms
underlying
each
regulation;
(iii)
fully
referencing
collected
cross-linking
them
available
databases.
Collectively,
FERREG
contains
51
targets,
718
regulators,
445
158
disease
responses.
can
be
accessed
at
https://idrblab.org/ferreg/.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
Briefings in Bioinformatics,
Journal Year:
2024,
Volume and Issue:
25(3)
Published: March 27, 2024
Ferroptosis
is
a
non-apoptotic,
iron-dependent
regulatory
form
of
cell
death
characterized
by
the
accumulation
intracellular
reactive
oxygen
species.
In
recent
years,
large
and
growing
body
literature
has
investigated
ferroptosis.
Since
ferroptosis
associated
with
various
physiological
activities
regulated
variety
cellular
metabolism
mitochondrial
activity,
been
closely
related
to
occurrence
development
many
diseases,
including
cancer,
aging,
neurodegenerative
ischemia-reperfusion
injury
other
pathological
death.
The
regulation
mainly
focuses
on
three
pathways:
system
Xc-/GPX4
axis,
lipid
peroxidation
iron
metabolism.
genes
involved
in
these
processes
were
divided
into
driver,
suppressor
marker.
Importantly,
small
molecules
or
drugs
that
mediate
expression
are
often
good
treatments
clinic.
Herein,
newly
developed
database,
named
'FERREG',
documented
(i)
providing
data
ferroptosis-related
diseases
occurrence,
progression
drug
response;
(ii)
explicitly
describing
molecular
mechanisms
underlying
each
regulation;
(iii)
fully
referencing
collected
cross-linking
them
available
databases.
Collectively,
FERREG
contains
51
targets,
718
regulators,
445
158
disease
responses.
can
be
accessed
at
https://idrblab.org/ferreg/.
