Triglyceride-glucose index, renal function and cardiovascular disease: a national cohort study

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 28, 2023

Abstract Background The triglyceride-glucose (TyG) index is a predictor of cardiovascular diseases; however, to what extent the TyG associated with diseases through renal function unclear. This study aimed evaluate complex association and using cohort design. Methods included participants from China Health Retirement Longitudinal Study (CHARLS) free at baseline. We performed adjusted regression analyses mediation Cox models. was calculated as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Renal defined by estimated glomerular filtration rate (eGFR). Results A total 6 496 were in this study. mean age 59.6 ± 9.5 years, 2996 (46.1%) females. During maximum follow-up 7.0 1 996 (30.7%) people developed diseases, including 541 (23.7%) cases heart 651 (10.0%) stroke. Both eGFR level significantly diseases. Compared lower (median level) ≥ 60 ml/minute/1.73 m 2 , those higher decreased had highest risk (HR, 1.870; 95% CI 1.131–3.069). Decreased mediated 29.6% associations between Conclusions combination could mediate risk.

Language: Английский

---

Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 24, 2024

Abstract Background Triglyceride-glucose (TyG) index has been determined to play a role in the onset of metabolic syndrome (MetS). Whether TyG and with combination obesity indicators are associated clinical outcomes MetS population remains unknown. Method Participants were extracted from multiple cycles National Health Nutrition Examination Survey (NHANES) between 1999 2018 years. Three constructed including index, combining waist circumference (TyG-WC), waist-to-height ratio (TyG-WHtR). The was defined according Cholesterol Education Program (NCPE) Adult Treatment Panel III. Kaplan-Meier (KM) curves, restricted cubic splines (RCS), Cox proportional hazard model used evaluate associations TyG-related indices mortality population. sensitive analyses performed check robustness main findings. Results There 10,734 participants included this study, 5,570 females 5,164 males. median age study 59 years old. multivariate regression showed high levels significantly all-cause [TyG index: adjusted (aHR): 1.36, 95%confidence interval (CI): 1.18–1.56, p < 0.001; TyG-WHtR aHR = 1.29, 95%CI: 1.13–1.47, 0.001]. Meanwhile, TyG-WC cardiovascular (TyG-WC: 1.45, 1.13–1.85, 0.004; TyG-WHtR: 1.50 1.17–1.92, 0.002). consistent significant correlations diabetes (TyG: 4.06, 2.81–5.87, TyG-WC: 2.55, 1.82–3.58, 2.53 1.81–3.54, 0.001). RCS curves non-linear trend (p for nonlinearity 0.004 0.001, respectively). supported positive Conclusion Our highlights value predicting survival would be surrogate biomarkers follow-up

Language: Английский

---

Metabolic score for insulin resistance (METS-IR) predicts all-cause and cardiovascular mortality in the general population: evidence from NHANES 2001–2018

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 10, 2024

Abstract Background The prevalence of obesity-associated insulin resistance (IR) is increasing along with the increase in obesity rates. In this study, we compared predictive utility four alternative indexes IR [triglyceride glucose index (TyG index), metabolic score for (METS-IR), triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and homeostatic model assessment (HOMA-IR)] all-cause mortality cardiovascular general population based on key variables screened by Boruta algorithm. aim was to find best replacement IR. Methods 14,653 participants were from National Health Nutrition Examination Survey (2001–2018). And TyG index, METS-IR, TG/HDL-C HOMA-IR calculated separately each participant according given formula. values assessed. Results Over a median follow-up period 116 months, total 2085 (10.23%) deaths 549 (2.61%) disease (CVD) related recorded. Multivariate Cox regression restricted cubic splines analysis showed that among indexes, only METS-IR significantly associated both CVD mortality, non-linear associations an approximate “U-shape”. Specifically, baseline lower than inflection point (41.33) negatively [hazard (HR) 0.972, 95% CI 0.950–0.997 mortality]. contrast, higher positively (HR 1.019, 1.011–1.026 HR 1.028, 1.014–1.043 mortality). We further stratified significant between levels predominantly present nonelderly aged < 65 years. Conclusions conjunction results algorithm, demonstrated more association U.S. other three HOMA-IR), particularly evident individuals under years old.

Language: Английский

---

Joint association of TyG index and high sensitivity C-reactive protein with cardiovascular disease: a national cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 7, 2024

Both the triglyceride-glucose (TyG) index, as a surrogate marker of insulin resistance, and systemic inflammation are predictors cardiovascular diseases; however, little is known about coexposures relative contributions TyG index to diseases. Using nationally representative data from China Health Retirement Longitudinal Study (CHARLS), we conducted longitudinal analyses evaluate joint mutual associations high-sensitivity C-reactive protein (hsCRP) with events in middle-aged older Chinese population.

Language: Английский

---

Association of the triglyceride-glucose index with all-cause and cardiovascular mortality in patients with cardiometabolic syndrome: a national cohort study

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Feb. 24, 2024

Abstract Objective This study aimed to evaluate the association of triglyceride-glucose (TyG) index with all-cause and cardiovascular mortality risk among patients cardiometabolic syndrome (CMS). Methods We performed a cohort 5754 individuals CMS from 2001–2018 National Health Nutrition Examination Survey. The TyG was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate Cox proportional hazards regression models assessed associations between . Non-linear correlations threshold effects were explored using restricted cubic splines two-piecewise model. Results Over median follow-up 107 months, 1201 deaths occurred, including 398 disease-related deaths. multivariate model showed positive mortality. Each one-unit increase in associated 16% (HR: 1.16, 95% CI 1.03, 1.31, P = 0.017) 39% 1.39, 1.14, 1.71, 0.001) after adjusting for confounders. revealed U-shaped ( nonlinear < 0.044), identifying values (all-cause mortality: 9.104; 8.758). A below these thresholds displayed negative 0.58, 0.38, 0.90, 0.015) but not 0.39, 0.12, 1.27, 0.119). Conversely, exceeding positively 1.35, 1.17, 1.55, 0.001; HR: 1.54, 1.25, 1.90, 0.001, respectively). Notably, higher (≥ values) significantly increased only aged under 55 compared those lower (< values). Conclusions demonstrated correlation CMS. 9.104 8.758 mortality, respectively, may be used intervention targets reduce premature death disease.

Language: Английский

---

Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 29, 2024

Abstract Background Triglyceride and glucose (TyG) index, a surrogate marker of insulin resistance, has been validated as predictor cardiovascular disease. However, effects TyG-related indices combined with obesity markers on diseases remained unknown. We aimed to investigate the associations between TyG index modified new-onset disease time-dependent predictive capacity using national representative cohort. Methods This study is retrospective observational cohort data from China Health Retirement Longitudinal Study (CHARLS) 7 115 participants. The was calculated Ln [fasting triglyceride (mg/dL) × fasting (mg/dL)/2]. were developed combining body mass (BMI), waist circumference (WC) waist-to‐height ratio (WHtR). used adjusted Cox proportional hazards regression analyze association based hazard (HR) Harrell’s C‐index. Results Over 7-year follow‐up period, 2136 participants disease, including 1633 cases coronary heart 719 stroke. Compared lowest tertile group, HR (95% CI) for in highest TyG, TyG-BMI, TyG-WC, TyG-WHtR 1.215 (1.088–1.356), 1.073 (0.967–1.191), 1.078 (0.970–1.198), 1.112 (1.002–1.235), respectively. C‐indices onset higher than other indices. Similar results observed Conclusion TyG-WhtR significantly associated diseases, outperformed identify individuals at risk incident event.

Language: Английский

---

Association between triglyceride-glucose related indices and mortality among individuals with non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 4, 2024

Abstract Background The prognostic value of triglyceride-glucose (TyG) related indices in non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic (MASLD) is still unclear. This study aimed to determine the associations between TyG-related and long-term mortality this population. Methods data came from National Health Nutrition Examination Survey (NHANES III) Death Index (NDI). Baseline TyG, TyG combining with body mass index (TyG-BMI), waist circumference (TyG-WC) were calculated, status was determined through 31 December 2019. Multivariate Cox restricted cubic spline (RCS) regression models performed evaluate relationship among participants NAFLD/MASLD. In addition, we examined association all-cause within subgroups defined by age, sex, race/ethnicity, fibrosis-4 (FIB-4). Results There 10,390 completed ultrasonography laboratory included study. NAFLD diagnosed 3672/10,390 (35.3%) participants, while MASLD 3556/10,390 (34.2%) amongst overall multivariate analyses showed high levels indices, particularly TyG-BMI TyG-WC significantly associated mortality, cardiovascular diabetes either MASLD. RCS curves a nonlinear trend three Subgroup that more suitable for predicting patients without advanced fibrosis. Conclusion Our highlights clinical survival NAFLD/MASLD would be surrogate biomarkers follow-up population

Language: Английский

---

Prognostic effect of triglyceride glucose-related parameters on all-cause and cardiovascular mortality in the United States adults with metabolic dysfunction-associated steatotic liver disease

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 1, 2024

Abstract Backgrounds Insulin resistance (IR) plays a vital role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, it remains unclear whether triglyceride–glucose (TyG) related parameters, which serve as useful biomarkers to assess IR, have prognostic effects on mortality outcomes MASLD. Methods Participants National Health and Nutrition Examination Survey (NHANES) database from 1999 2018 years were included. TyG its parameters [TyG-waist circumference (TyG-WC) TyG-waist height ratio (TyG-WHtR)] calculated. Kaplan–Meier curves, Cox regression analysis, restricted cubic splines (RCS) conducted evaluate association between TyG-related indices with all-cause cardiovascular adults The concordance index (C-index) was used prediction accuracy indices. Results A total 8208 (4209 men 3999 women, median age 49.00 years) MASLD included this study. Multivariate-adjusted analysis revealed that high quartile levels significantly associated participants [ adjusted hazard (aHR) = 1.25, 95% confidence interval (CI) 1.05–1.50, P 0.014; TyG-WC aHR for 1.28, CI 1.07–1.52, 0.006; TyG-WHtR 1.50, 1.25–1.80, < 0.001; 1.81, 1.28–2.55, 2.22, 1.55–3.17, 0.001]. C-index predicting 0.563 index, 0.579 0.585 respectively. Regarding mortality, 0.561 0.607 0.615 Nonlinear trends observed ( 0.001 0.012, respectively). non-linear relationship 0.025). Subgroup suggested aged 65 old those without comorbidities more sensitive Conclusion Findings study highlight predictive value indices, especially would be surrogate clinical management

Language: Английский

---

Association of the triglyceride glucose-body mass index with the extent of coronary artery disease in patients with acute coronary syndromes

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 13, 2024

Abstract Background Studies have shown that insulin resistance is strongly associated with the development of cardiovascular disease, and triglyceride glucose-body mass index (TyG-BMI index) considered to be a reliable surrogate marker resistance. There are limited studies on relationship between TyG-BMI extent coronary artery disease in patients acute syndrome (ACS). This study aimed investigate ACS. Methods Overall, 2,317 ACS who underwent percutaneous intervention at Affiliated Hospital Zunyi Medical University were included this study. The was grouped according tertile method. quantitatively assessed using SYNTAX score, which categorised as low (≤ 22), intermediate (23–32), high risk (≥ 33). Results In overall population, multivariate logistic regression analyses showed mid/high score (odds ratio [OR] = 1.0041; 95% confidence interval [CI] 1.0000–1.0079; p 0.0310). Subgroup an independent factor for female after adjusting multiple confounders (OR 1.0100; CI 1.0000–1.0200; 0.0050), 2.49 times higher T3 group 2.4900; 1.2200–5.0600; 0.0120). Restricted cubic spline analysis linear correlation complex (SYNTAX > 22) women patients, inclusion did not improve predictive power underlying model (net reclassification improvement: 0.0867 [-0.0256–0.1989], 0.1301; integrated discrimination 0.0183 [0.0038–0.0329], 0.0135). Conclusions linearly degree patients. However,

Language: Английский

---

Superiority of the triglyceride glucose index over the homeostasis model in predicting metabolic syndrome based on NHANES data analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 5, 2024

The triglyceride-glucose (TyG) index is a simple and inexpensive new marker of insulin resistance that being increasingly used for the clinical prediction metabolic syndrome (MetS). Nevertheless, there are only few comparative studies on its predictive capacity MetS versus those using traditional homeostasis model assessment (HOMA). We conducted cross-sectional study database from National Health Nutrition Examination Survey (1999 March to 2020 pre-pandemic period). Using statistical methods, we compared abilities TyG HOMA (including [HOMA-IR] beta-cell function [HOMA-β]) MetS. A total 34,195 participants were enrolled divided into group (23.1%) or no (76.9%) according International Diabetes Federation (IDF) diagnostic criteria. After applying weighted data, baseline characteristics population described. Following exclusion medication influences, final count was 31,304 participants. Receiver operating characteristic curve analysis revealed while distinguishing between MetS, had an area under (AUC) 0.827 (sensitivity = 71.9%, specificity 80.5%), cutoff 8.75, slightly outperforming HOMA-IR (AUC 0.784) HOMA-β 0.614) with significance P < 0.01. prevalence in calculated value 30.9%, which higher than reported IDF Weighted data univariate multivariate logistic regression displayed independent association elevated risk Subgroup further differences ability among adult populations across various genders ethnicities, whereas such not observed children adolescents. better predicting may identify more patients MetS; thus, applications setting can be appropriately increased.

Language: Английский

---