Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin

Hypertension, Journal Year: 2024, Volume and Issue: 81(7), P. 1637 - 1643

Published: May 16, 2024

Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals.

Language: Английский

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Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 8, 2025

Among hypertensive cohorts across different nations, the relationship between triglyceride-glucose index (TyG) and its conjunction with obesity metrics in relation to cardiovascular disease (CVD) incidence mortality remains be elucidated. This study enrolled 9,283, 164,357, 5,334 hypertensives from National Health Nutrition Examination Survey (NHANES), UK Biobank (UKBB), Shanghai Pudong cohort. The related outcomes for CVD were defined by multivariate Cox proportional hazards models, Generalized Additive Models Mendelian randomization analysis. Mediation analysis explored mediating role of inflammatory markers above relationships. Five measures insulin resistance linked death a U-shaped pattern, highest group having risk increases. Higher glucose triglyceride-waist height ratio (TyG-WHTR) was higher all-cause (UKBB: HR 1.21, 95%CI 1.16–1.26, NHANES: 1.17, 1.00–1.36), 1.36, 1.23–1.49, 1.32, 1.00–1.72) risks. In China cohort, triglyceride/high-density lipoprotein-cholesterol (TG/HDL_C) associated risks stroke (HR 1.31, 1.00–1.73 1.67, 1.06–2.63). Inflammation like systemic response (SIRI) C-reactive protein (CRP) partially explained these links, CRP stronger effect. Genetically predicted TyG also (OR 1.26, 1.10–1.45) risk. An elevated indices are significantly correlated an increased three national cohorts. These anticipated serve as valid predictors incident individuals hypertension.

Language: Английский

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Triglyceride-glucose index (TyG) as a novel biomarker in the era of cardiometabolic medicine

International Journal of Cardiology, Journal Year: 2024, Volume and Issue: 418, P. 132663 - 132663

Published: Oct. 18, 2024

Language: Английский

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The triglyceride-glucose index trajectories are associated with cardiovascular diseases in people living with HIV: evidence from a prospective cohort study in China, 2005–2022

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 5, 2025

The triglyceride-glucose (TyG) index has been validated as a novel biomarker for cardiovascular disease (CVD) risk. However, the prospective relationship between baseline and long-term trajectories of TyG CVD risk in people living with HIV (PLWH) remains unexplored. This cohort study included 16,122 treatment-naive PLWH who initiated antiretroviral therapy (ART) at Third People's Hospital Shenzhen from 2005 to 2022. was calculated Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Group-based trajectory modeling used identify distinct over follow-up period. Hazard ratios (HRs) 95% confidence intervals (CIs) were using multivariate Cox proportional hazards models assess association Nonlinear relationships investigated restricted cubic spline plot. During median 70 months, 214 developed CVD. Each 1-standard deviation (SD) increase associated 39% higher (HR 1.39, CI 1.22, 1.59) after adjusting covariates. Participants categorized into four groups: low-stable, low-moderate-stable, high-moderate-stable, high-increasing. After adjustment, high-increasing group had 2.92-fold (95% 1.68, 5.05) increased compared low-stable group. plot showed an upward trend occurrence (P < 0.001), threshold 8.479 all patients. Significantly positive correlations observed both below HR 3.38 1.07, 10.68) above 1.43 1.92) (both P 0.05). stratifying by sex, curves men nearly identical those overall HIV-infected population. While women also demonstrated nonlinear similar (8.484), not statistically significant. Higher levels significantly PLWH. These findings underscore valuable marker assessment PLWH, particularly male populations. Incorporating monitoring routine clinical assessments could enhance stratification inform tailored prevention strategies. Further studies are needed validate these other cohorts explore their applicability women.

Language: Английский

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The association between triglyceride-glucose index and its combination with systemic inflammation indicators and all-cause and cardiovascular mortality in the general US population: NHANES 1999–2018

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 10, 2024

Language: Английский

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Association of inflammatory score with all-cause and cardiovascular mortality in patients with metabolic syndrome: NHANES longitudinal cohort study

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 1, 2024

Inflammatory scores are known to reflect the systemic inflammatory burden. Despite this, association between score and risk of all-cause cardiovascular mortality in patients with metabolic syndrome (MetS) remains poorly understood. To address this gap literature, study investigated potential these two factors.

Language: Английский

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Predictive value of the triglyceride-glucose index for short- and long-term all-cause mortality in patients with critical coronary artery disease: a cohort study from the MIMIC-IV database

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 22, 2024

Triglyceride-glucose (TyG) index is linked to a poor prognosis for cardiovascular condition and valid indicator of insulin resistance. This study evaluated the potential predicting usefulness TyG all-cause mortality, both short- long-term, those concerning critical coronary artery disease (CAD). In this study, information from 5452 critically-ill individuals with CAD in intensive care units were gathered Medical Information Marketplace Intensive Care (MIMIC-IV) database. Depending on degree, patients categorized into three categories. Clinical outcomes included short-term (30-day) long-term (365-day) mortality. The corresponding relationships involving clinical examined by deploying restricted cubic spline (RCS) regression analysis Cox proportional risk regression. An increased was associated 30-day (Tertile 1: 6.1%, Tertile 2: 7.3%, 3: 9.2%, P = 0.001) 365-day 15.2%, 17.0%, 19.6%, 0.002) death rates across all causes. multiple variables indicates that higher indices all-caused mortality hazard ratios throughout short long terms, larger predictive value former. RCS analyses suggested notably linearly index. reliable predictor at different stages critically ill patients, ability Early intervention elevated may improve their survival outcomes. Future research should delve understanding its pathophysiological mechanisms develop strategies based index, providing new insights enhance outlook patients.

Language: Английский

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The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China

Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 5, 2025

Background The triglyceride-glucose (TyG) index has emerged as a credible surrogate indicator of insulin resistance in recent years. This study aimed to investigate the relationship between TyG and deterioration kidney function patients with cardiovascular-kidney-metabolic (CKM) syndrome.

Language: Английский

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U-shaped association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and mortality risk in obese adults: evidence from NHANES 1999–2018

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 10, 2025

Obesity, often accompanied by dyslipidemia and increased cardiovascular risk, poses a significant threat to overall mortality. The non-high-density lipoprotein cholesterol high-density ratio (NHHR) has been identified as valuable parameter for assessing dyslipidemia. goal of the study was elucidate relationship between NHHR mortality in obese populations. Data cohort were sourced from National Health Nutrition Examination Survey (1999-2018). association all causes disease examined through multivariable Cox regression restricted cubic splines (RCS). Segmented subgroup analyses conducted when segmented effects identified. reliability results confirmed multiple sensitivity analyses. A total 7,504 participants included analysis. During median follow-up 119 months, 866 subjects died causes, which 318 related diseases. U-shaped found utilizing RCS analysis, with all-cause exhibiting lowest risk points at 3.409 3.369, respectively. fully adjusted model revealed negative (HR = 0.68, 95% CI: 0.49-0.94) 0.82, 0.67-1.00) per 1 mmol/L increase levels below cut-off value. On other hand, above point, positively correlated 1.18, 1.02-1.36) 1.13, 1.01-1.28). this accordance earlier findings, no interactions discovered across different subgroups. In adults, displayed death. Monitoring managing population may help mitigate

Language: Английский

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Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 19, 2025

This cross-sectional study aimed to investigate the association between TyG index and both obesity indicators hypertension among American adults. Data were drawn from 4,813 adults in 2013–2018 National Health Nutrition Examination Survey (NHANES). Multivariate logistic regression models indicated significant associations obesity-related indices with hypertension. Using Cox analysis, we examined relationship relation hypertensive prognosis, employing threshold effect analysis fitted smoothed curves for consistency. Subgroup analyses interaction tests conducted. Results showed strong correlations TyG, TyG-BMI, TyG-WHtR, TyG-WC hypertension, odds ratios (ORs) of rising across quartiles (Q1–Q4). Cardiovascular mortality revealed that (HR = 1.89, 95% CI (1.03,3.51), P < 0.05) Q2 group 4.93, (1.29,18.80), significantly associated increased risk. A positive correlation was noted below a 8.1, inverse beyond this point. The exhibited although weakened after reaching certain threshold. These findings suggested related are may aid understanding risk stratification context.

Language: Английский

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