The association between triglyceride-glucose index and its combination with post-stroke depression: NHANES 2005–2018

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 14, 2025

Growing evidence indicates a link between insulin resistance and post-stroke depression (PSD). This study employed the triglyceride glucose (TyG) index as measure of to investigate its relationship with PSD. cross-sectional utilized data from National Health Nutrition Examination Survey (2005–2018). PSD was assessed using patient health questionnaires, while TyG calculated based on fasting venous blood levels. The formula used for is ln[triglycerides (mg/dL) × (mg/dL)/2]. Participants were categorized into four groups according quartiles. A weighted multivariable logistic regression model applied examine total 1217 patients included in study, which 232 diagnosed divided quartiles (Q1-Q4) analysis. After adjusting potential confounders, we found significant positive association highest quartile (Q4: ≥9.33) (OR = 2.51, 95% CI: 1.04–6.07, p 0.041). suggests that U.S. adult stroke population, individuals higher indices are more likely experience depressive symptoms. Subgroup analysis further confirmed stable independent (all trend > 0.05). In this large our results suggest among US adults who have experienced stroke, those levels exhibit provides novel approach clinical prevention Patients population may require closer psychological monitoring timely intervention. Additionally, since only levels, it can help identify high-risk patients, particularly regions limited healthcare resources.

Language: Английский

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Major depression and the biological hallmarks of aging

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 83, P. 101805 - 101805

Published: Nov. 21, 2022

Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity outcome. In recent years, several lines of evidence have suggested that individuals with MDD an elevated risk age-related adverse outcomes across lifespan. This review provided a significant overlap between biological abnormalities in changes commonly observed during aging process (i.e., hallmarks aging). Based on such evidence, we formulate mechanistic model showing how can be common denominator mediate health MDD. Finally, proposed roadmap for novel studies investigate intersection biology MDD, including use geroscience-guided interventions, as senolytics, delay or improve major depression targeting aging.

Language: Английский

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Gender Differences in Insulin Resistance: New Knowledge and Perspectives

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(10), P. 7845 - 7861

Published: Sept. 27, 2023

Insulin resistance is the main mechanism in a whole series of pathological conditions, which are not only metabolic interest but also systemic type. This phenomenon means that body’s cells become less sensitive to hormone insulin, leading higher levels insulin blood. can be found both men and women particular, latter, it mainly after menopause. Premenopause, hormonal fluctuations during menstrual cycle, presence estrogen affect sensitivity. Androgens, such as testosterone, typically contribute resistance. In sexes, different human body types distribution location fat, influencing development diabetes cardiovascular disease. associated with some neurological neurogenerative disorders, polycystic ovary syndrome, atherosclerosis, neoplastic pathologies. A healthy lifestyle, including regular physical activity, balanced diet, self-maintenance, help prevent onset resistance, regardless gender, although habits between greatly implementation preventative guidelines fighting manifestations this disorder. review may shed light on gender differences diseases by placing necessary focus personalized medical management inspiring differentiated therapeutic approaches.

Language: Английский

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Obstructive sleep apnea (OSA) is associated with increased risk of early-onset sarcopenia and sarcopenic obesity: Results from NHANES 2015-2018

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(6), P. 891 - 899

Published: Feb. 21, 2024

Language: Английский

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Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 10, 2024

Abstract Triglyceride glycemic-body mass index (TyG-BMI) is a simple and reliable surrogate for insulin resistance (IR). However, it still unclear if TyG-BMI has any predictive value in patients having percutaneous coronary intervention (PCI) ST-segment elevation myocardial infarction (STEMI). The purpose of this study was to examine the index's prognostic significance power with STEMI. comprised total 2648 consecutive STEMI who underwent PCI. primary endpoint occurrence major adverse cardiovascular events (MACE), defined as combination all-cause death, nonfatal infarction, stroke, revascularization. formulated ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2] BMI. 193 all experienced MACE over median follow-up 14.7 months. There statistically significant difference between Kaplan–Meier survival curves tertiles (log-rank test, p = 0.019) cumulative incidence MACE. adjusted HRs middle highest quartiles compared lowest quartile were 1.37 (95% CI 0.92, 2.03) 1.53 1.02, 2.29), respectively, fully Cox regression model. At six months, one year, three years, area under curve (AUC) predicting 0.691, 0.666, 0.637, respectively. Additionally, adding risk prediction model enhanced outcome prediction. In undergoing PCI, independently linked could be solid way assess prognosis.

Language: Английский

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