Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial DOI Creative Commons
Rudi Putranto, Siti Setiati, Martina Wiwie Setiawan Nasrun

et al.

Narra J, Journal Year: 2024, Volume and Issue: 4(3), P. e1342 - e1342

Published: Oct. 30, 2024

The coexistence of depression and type 2 diabetes mellitus (T2DM) can significantly worsen disease prognosis lower quality life. Emerging evidence suggests that vitamin D deficiency contributes to the progression T2DM is closely associated with development depression. aim this study was investigate effects cholecalciferol on in patients T2DM, exploring its mechanisms by analyzing impact C-peptide, serotonin, neurotrophin-3 levels. A double-blind, randomized, placebo-controlled clinical trial conducted at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from April 2021 September 2022. Patients depressive symptoms were randomly assigned two groups: received 4000 IU daily a placebo for 12 weeks. Depression assessed using Beck Inventory-II (BDI-II) before weeks after intervention. levels measured end fourth week intervention enzyme-linked immunosorbent assay (ELISA) method. Between-group comparisons made independent Student t-tests Mann-Whitney U tests. Paired or Wilcoxon tests applied within-group between pre- post-intervention. total 70 included study, comprising 38 group 32 group. C-peptide increased compared (p=0.006). No significant differences observed serotonin NT-3 had greater reduction BDI-II scores (p<0.001). This highlights taking might help ease mild moderate enhancing c-peptide levels, though are still unclear.

Language: Английский

Mental Health Applications of Generative AI and Large Language Modeling in the United States DOI Open Access
Srikanta Banerjee, Patrick Dunn,

Scott Conard

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(7), P. 910 - 910

Published: July 12, 2024

(1) Background: Artificial intelligence (AI) has flourished in recent years. More specifically, generative AI had broad applications many disciplines. While mental illness is on the rise, proven valuable aiding diagnosis and treatment of disorders. However, there little to no research about precisely how much interest technology. (2) Methods: We performed a Google Trends search for “AI health” compared relative volume (RSV) indices “AI”, Depression”, anxiety”. This time series study employed Box–Jenkins modeling forecast long-term through end 2024. (3) Results: Within United States, steadily increased throughout 2023, with some anomalies due media reporting. Through predictive models, we found that this trend predicted increase 114% year 2024, public being rise. (4) Conclusions: According our study, awareness drastically especially health. demonstrates increasing health AI, making advocacy education technology paramount importance.

Language: Английский

Citations

5
Mortality risk among adult americans living with cancer and elevated CRP DOI
Srikanta Banerjee, Jagdish Khubchandani,

Shalika Tisinger

et al.

Cancer Epidemiology, Journal Year: 2024, Volume and Issue: 90, P. 102569 - 102569

Published: April 9, 2024

Language: Английский

Citations

3
Food insecurity and the risk of mortality among Hispanics with hypertension DOI
Srikanta Banerjee,

Tim Radak,

Jagdish Khubchandani

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(11), P. 2555 - 2561

Published: July 17, 2024

Language: Английский

Citations

1
Food insecurity and mortality risk among adults with Chronic Kidney Disease: A longitudinal cohort study of NHANES DOI
Jagdish Khubchandani, Srikanta Banerjee,

Karen Kopera-Frye

et al.

Nutrire, Journal Year: 2024, Volume and Issue: 49(2)

Published: Oct. 7, 2024

Language: Английский

Citations

1
Depressive symptoms and its relation to all-cause and cardiovascular mortality among United States adults with different diabetic status DOI

Hua-Zhao Xu,

Xiangda Meng, Qian Liu

et al.

The International Journal of Psychiatry in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Objective The relationship between diabetes, depressive symptoms, and mortality is well established. However, the effect of symptoms on prediabetes its with remains unclear. This study seeks to investigate effects across different diabetic statuses. Methods analyzed data from National Health Nutrition Examination Survey (NHANES) 1999 2018, a final sample size 36,246 participants. Mortality status cause death were determined by cross-referencing records publicly accessible Death Index through 2019. Kaplan-Meier survival curves Cox regression analysis utilized assess statuses nondiabetic prediabetic diabetic. Results In non-diabetic group, no depression severity all-cause or cardiovascular was found in models. however, hazard ratios increased for both mild (HR = 1.349, 95% CI 1.138-1.600) moderate-to-severe 1.651, 1.309-2.082). surprisingly, risk somewhat lower than pre-diabetic group 1.279, 1.084-1.509 HR 1.285, 1.056-1.563 symptoms). Similar patterns noted disease (CVD) mortality, where moderate-severe even greater 1.834, 1.180-2.851). Conclusion this prospective cohort nationally representative U.S. adults, positive association These findings highlight importance evaluating glycemic spectrum, especially among individuals prediabetes.

Language: Английский

Citations

1
Intervenciones de afrontamiento ante la depresión en pacientes con Diabetes Mellitus Tipo 2 DOI Open Access
Fernando Urrutia, Andrea Tufiño

Mediciencias UTA (Impresa)/Mediciencias UTA (En línea), Journal Year: 2024, Volume and Issue: 8(2), P. 56 - 75

Published: April 1, 2024

Introducción: La diabetes mellitus tipo 2 (DM2) y la depresión son enfermedades crónicas graves que a menudo coexisten. es casi el doble de frecuente en personas con DM2 población general. Cuando ambas condiciones están presentes, se asocian un peor control glucémico, menor autocuidado, reducción calidad vida, mayor riesgo complicaciones una mortalidad. A pesar su importancia, número significativo pacientes permanecen sin ser tratados o incluso diagnosticados. Existe falta estudios guías manejo sobre tratamiento simultáneo estas dos condiciones. Objetivos: Esta revisión bibliográfica tiene como objetivo analizar las diferentes intervenciones afrontamiento contra propósito tener panorama completo opciones disponibles e identificar estrategias más efectivas. Además, los factores predisponen desarrollar depresión. Metodología: Se realizó metaanálisis, ensayos clínicos aleatorizados revisiones sistemáticas publicados entre 2018 2024, obtenidos bases datos PubMed, Google Académico Scopus. identificaron riesgo, depresión, sus definiciones, eficacia modos aplicación respaldados por evidencia científica. seleccionaron artículos relevantes clasificó información significativa. Principales resultados: Los principales para incluyen aspectos biológicos (hiperglucemia, daño vascular, complicaciones), conductuales (tratamiento obesidad, inactividad física, alteraciones del sueño), socioeconómicos (bajo nivel socioeconómico, gastos medicación, inestabilidad social, bajo educativo), ambientales psicológicos. Las efectivas afrontar terapia cognitivo-conductual (TCC), TCC grupal, ejercicio, farmacológico (ISRS) online. Para mejorar tanto destacan farmacoterapia combinación ejercicio. selección intervención adecuada debe considerar gravedad síntomas depresivos, preferencias paciente, recursos disponibles, efectividad posibles efectos glucémico. modelos escalonados brindan guía útil esta

Citations

0
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial DOI Creative Commons
Rudi Putranto, Siti Setiati, Martina Wiwie Setiawan Nasrun

et al.

Narra J, Journal Year: 2024, Volume and Issue: 4(3), P. e1342 - e1342

Published: Oct. 30, 2024

The coexistence of depression and type 2 diabetes mellitus (T2DM) can significantly worsen disease prognosis lower quality life. Emerging evidence suggests that vitamin D deficiency contributes to the progression T2DM is closely associated with development depression. aim this study was investigate effects cholecalciferol on in patients T2DM, exploring its mechanisms by analyzing impact C-peptide, serotonin, neurotrophin-3 levels. A double-blind, randomized, placebo-controlled clinical trial conducted at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from April 2021 September 2022. Patients depressive symptoms were randomly assigned two groups: received 4000 IU daily a placebo for 12 weeks. Depression assessed using Beck Inventory-II (BDI-II) before weeks after intervention. levels measured end fourth week intervention enzyme-linked immunosorbent assay (ELISA) method. Between-group comparisons made independent Student t-tests Mann-Whitney U tests. Paired or Wilcoxon tests applied within-group between pre- post-intervention. total 70 included study, comprising 38 group 32 group. C-peptide increased compared (p=0.006). No significant differences observed serotonin NT-3 had greater reduction BDI-II scores (p<0.001). This highlights taking might help ease mild moderate enhancing c-peptide levels, though are still unclear.

Language: Английский

Citations

0