Drug-Delivery Based on Encapsulation for Photodynamic Therapy and Photothermal Therapy DOI Creative Commons
María Paulina Romero, Michel Gonzalez

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Photodynamic therapy (PDT) and photothermal (PTT) have shown significant promise in treating cancer other illnesses. Photosensitizers (PSs) agents (PTAs) play crucial roles PDT PTT to enhance treatment efficiently. The stability, solubility, toxicity of PSs PTAs are the main challenges improving effectiveness these agents. This chapter examines several encapsulation techniques PS reduce limitations. Liposomes, hydrogels, inorganic particles, metal-organic frameworks, covalent organic frameworks offer diverse important strategies for PS, agents’ delivery. These nanocarrier systems unique advantages such as high efficiency, sustained drug release, enhanced cytotoxicity against cells, biocompatibility. Moreover, nanocapsules create a localized depot at target site present specific benefits tailored requirements different therapeutic applications, making them valuable tools developing advanced targeted delivery diseases. Overall, encapsulating photosensitizers enhancing efficacy safety PTT, promising candidates applications.

Language: Английский

Design strategies and applications of cyanine dyes in phototherapy DOI
Jie Yuan, Han‐xue Yang,

Wenhui Huang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

An overview of cyanine dye-based phototherapy agents, including the design strategies, relationships between molecular structures and properties, as well applications in photodynamic therapy, photothermal multimodal combined therapy.

Language: Английский

Citations

6
Dual-responsive hyaluronic acid-based hydrogel as a drug carrier for combined chemo-photodynamic therapy DOI
Danyang Li, Shizhen Zhao,

Yuanpeng Cai

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: 229, P. 113883 - 113883

Published: March 6, 2025

Language: Английский

Citations

0
Enhanced Intracellular IR780 Delivery by Acidity-Triggered PEG-Detachable Hybrid Nanoparticles to Augment Photodynamic and Photothermal Combination Therapy for Melanoma Treatment DOI Creative Commons

Min‐Chen Tsai,

L. T. Hsiao,

Yen-Hsuan Chang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

The PEGylation of drug-carrying nanoparticles has often been used to prolong blood circulation and improve drug deposition at tumor sites. Nevertheless, the PEG-rich hydrophilic surfaces retard release payloads internalization therapeutic by cancer cells, thus lowering anticancer efficacy. To boost potency combined photodynamic therapy (PDT) photothermal (PTT) against melanoma conquering PEG dilemma, herein, hybrid PEGylated chitosan-covered polydopamine (PDA) (PCPNs) with acidity-elicited detachment ability were fabricated as carriers IR780, a small-molecule photosensitizer for PTT PDT. IR780@PCPNs displayed uniform, solid-like spherical shape sound colloidal stability. Under near-infrared (NIR) irradiation, showed prominent conversion efficiency (ca. 54.6%), robust stability, reduced IR780 photobleaching, sufficient singlet oxygen (1O2) production, glutathione-depleting ability. Moreover, environmental pH being from 7.4 5.0 37 °C, decreased interactions between PCPNs due increased protonation phenolic hydroxyl residues within PDA primary amine groups chitosan accelerated species IR780@PCPNs. Importantly, cellular uptake B16F10 was remarkably promoted in weakly acidic milieu upon driven disintegration acid-labile benzoic imine. With NIR internalized generated hyperthermia 1O2 damage mitochondria, thereby effectively inhibiting proliferation cells. Collectively, our findings present practical strategy amplifying efficacy PDT using PEG-detachable

Language: Английский

Citations

0
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy DOI
Sankha Bhattacharya, Paul Beninger

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(10), P. 727 - 741

Published: March 1, 2024

Abstract: This review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within embryonic landscape nanotechnology. Nanoparticles, pivotal in treatment, are systematically examined their diverse physicochemical structures, categorized organic (lipid-based, protein-based, and polymer-assisted) inorganic (carbon-based metal) varieties. A significant focus is placed on CMNPs, which serve an innovative drug delivery vehicle, overcoming limitations associated with conventional nanoparticle therapies. manuscript accurately explores advantages challenges various membranes, including those derived from cells, red blood platelets, stem white cells. Importance roles enhancing precision, immune system circumvention, targeted recognition. Detailed insights into crafting CMNPs provided, elucidating membrane extraction fusion techniques, such sonication, extrusion, co-extrusion, microfluidic electroporation. Maintaining integrity during benefits coating techniques augmenting biocompatibility underscored. comprehensive resource consolidates latest advancements delivery, positioning itself at forefront nanotechnology biomedicine research. Encapsulating methodologies like electrospray, chemical conjugation, this showcases expanding toolbox available to researchers dynamic field. Focusing unique characteristics multifaceted applications biomedical research, particularly tumour therapy. It provides indepth analysis stability, evasion capabilities, increased payload capacity, retained biological functionality. The outlines current future prospects chemotherapy, photothermal photodynamic therapy, immunotherapy, gene therapeutic methods. concludes by highlighting transformative potential reshaping treatment.

Language: Английский

Citations

2
Blood-brain barrier permeable carbon nano-assemblies for amyloid-β clearance and neurotoxic attenuation DOI
Tongtong Hou, Qian Yang,

Minling Ding

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114182 - 114182

Published: Aug. 30, 2024

Language: Английский

Citations

1
Construction of Methotrexate-Loaded Bi2S3 Coated with Fe/Mn-Bimetallic Doped ZIF-8 Nanocomposites for Cancer Treatment Through the Synergistic Effects of Photothermal/Chemodynamic/Chemotherapy DOI Creative Commons
Pranjyan Dash, Nandini Nataraj, Pradeep Kumar Panda

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 222 - 234

Published: Oct. 17, 2024

A combination of therapeutic modalities in a single nanostructure is crucial for successful cancer treatment. Synergistic photothermal therapy (PTT) can enhance the effects chemodynamic (CDT) and chemotherapy, which could intensify efficacy to induce cell apoptosis. In this study, Fe Mn on zeolitic imidazolate framework (ZIF-8) (Fe/Mn-ZIF-8; FMZ) were synthesized through ion deposition. Furthermore, bismuth sulfide nanorods (Bi2S3 NRs; BS NRs) via hydrothermal process coated onto FMZ generate core-shell structure Bi2S3@FMZ nanoparticles (B@FMZ). Next, methotrexate (MTX) was loaded effectively porous surface ZIF-8 form B@FMZ/MTX nanoparticles. The Fenton-like reaction catalyzes Fe2+/Mn2+ ions by decomposing H2O2 tumor microenvironment, resulting formation toxic hydroxyl radicals (·OH), promotes CDT effect killing cells. under 808 nm laser irradiation, these B@FMZ showed strong PTT effect, owing presence intense NRs as agent. exhibited prominent drug release efficiency 87.25% at pH 5.5 near-infrared irradiation due promote delivery performance. subjected dual-modal imaging, guided magnetic resonance X-ray computed tomography imaging. Both vitro vivo results suggested that enhanced antitumor combined PTT, CDT, chemotherapy. Therefore, exhibit good biocompatibility are promising candidates

Language: Английский

Citations

1
Novel Progress of Covalent Organic Frameworks in the Biomedicine Approaches: From Synthesis to Cutting Edge Therapeutics DOI
Mojtaba Moharramnejad, Taraneh Sayah,

Zahra Ghehsareh

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106320 - 106320

Published: Oct. 23, 2024

Language: Английский

Citations

1
Dual-Responsive Hyaluronic Acid-Based Hydrogel as a Drug Carrier for Combined Chemo-Photodynamic Therapy DOI
Danyang Li, Shizhen Zhao,

Yuanpeng Cai

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Graphene-Based Nanocomposites against Hepatocellular Carcinoma via Chemo/Photothermal/Photodynamic Synergistic Therapy DOI
Guohua Yang, Qiaowen Wang, Guolong Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(24), P. 28541 - 28552

Published: Dec. 10, 2024

Single chemotherapy (CT) has difficulty meeting the clinical needs of patients with intermediate and advanced hepatocellular carcinoma (HCC). To solve this problem, graphene-based nanocomposites (DOX/IR820@GNPs) were prepared used to combat HCC through combined photothermal therapy (PTT), photodynamic (PDT), CT by using membrane-penetrating peptide (tLyp-1) hyaluronic acid as tumor-targeting materials IR820@GQDs doxorubicin hydrochloride (DOX) photosensitizer chemotherapeutic drug. The well dispersed in water particle size 98–145 nm zeta −6.0 ∼ −12.8 mV have absorption UV, visible, near-infrared (NIR) regions. Therefore, DOX/IR820@GNPs not only capability fluorescence imaging but also produce reactive oxygen species effects under NIR irradiation. In addition, are biocompatible, can be internalized into HepG2 cells enriched at tumor site dual targeting, accelerate release DOX microacid environment. Importantly, due above properties, PTT PDT kill tumors directly Meanwhile, effect is enhanced high-temperature environments. Finally, optimal anti-HCC was achieved synergistic sensitization PTT/PDT CT.

Language: Английский

Citations

0
Drug-Delivery Based on Encapsulation for Photodynamic Therapy and Photothermal Therapy DOI Creative Commons
María Paulina Romero, Michel Gonzalez

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Photodynamic therapy (PDT) and photothermal (PTT) have shown significant promise in treating cancer other illnesses. Photosensitizers (PSs) agents (PTAs) play crucial roles PDT PTT to enhance treatment efficiently. The stability, solubility, toxicity of PSs PTAs are the main challenges improving effectiveness these agents. This chapter examines several encapsulation techniques PS reduce limitations. Liposomes, hydrogels, inorganic particles, metal-organic frameworks, covalent organic frameworks offer diverse important strategies for PS, agents’ delivery. These nanocarrier systems unique advantages such as high efficiency, sustained drug release, enhanced cytotoxicity against cells, biocompatibility. Moreover, nanocapsules create a localized depot at target site present specific benefits tailored requirements different therapeutic applications, making them valuable tools developing advanced targeted delivery diseases. Overall, encapsulating photosensitizers enhancing efficacy safety PTT, promising candidates applications.

Language: Английский

Citations

0