EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104896 - 104896
Published: Dec. 1, 2023
Sensory impairment has been related to age-associated cognitive decline. While these associations were investigated primarily in the auditory and visual domain, other senses such as touch have rarely studied. Thus, it remains open whether results are specific for particular sensory domains, or rather point a fundamental role of deficits
Language: Английский
The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100094 - 100094
Published: Feb. 1, 2025
Language: Английский
Citations
1
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Feb. 28, 2024
Sensorineural hearing loss (SNHL) is a category of that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness auditory trauma, results cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers an abnormality the brain’s higher intellectual processes related learning, memory, thinking judgment can lead severe learning memory deficits. Studies have established strong correlation between SNHL CI, but it remains unclear how contributes CI. The purpose this article describe three hypotheses regarding relationship, mainstream load hypothesis, co-morbidity sensory deprivation as well latest research progress each hypothesis.
Language: Английский
Citations
6
Brain, Journal Year: 2024, Volume and Issue: 147(10), P. 3395 - 3408
Published: March 8, 2024
Abstract Hearing difficulty (HD) is a major health burden in older adults. While ageing-related changes the peripheral auditory system play an important role, genetic variation associated with brain structure and function could also be involved HD predisposition. We analysed large-scale genome-wide association study (GWAS; ntotal = 501 825, 56% females) GWAS data related to 3935 imaging-derived phenotypes (IDPs) assessed up 33 224 individuals (52% using multiple MRI modalities. To investigate pleiotropy function, we conducted correlation, latent causal variable, Mendelian randomization multivariable generalized linear regression analyses. Additionally, performed local correlation multi-trait co-localization analyses identify genomic regions loci implicated pleiotropic mechanisms shared between IDPs. observed widespread of 120 IDPs females, 89 males 171 sex-combined analysis. The variable analysis showed that some these correlations due cause-effect relationships. For seven them, effects were confirmed by approach: vessel volume→HD analysis; hippocampus volume→HD, cerebellum grey matter primary visual cortex HD→fluctuation amplitudes node 46 resting-state functional dimensionality 100 females; global mean thickness→HD HD→mean orientation dispersion index superior corona radiata males. identified 13 signal for rs13026575 variant HD, volume SPTBN1 transcriptomic regulation females. Brain may have role sex differences predisposition via possible relationships regulatory mechanisms.
Language: Английский
Citations
6
Nature Aging, Journal Year: 2024, Volume and Issue: 4(4), P. 568 - 583
Published: March 15, 2024
Language: Английский
Citations
6
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(3), P. 2102 - 2112
Published: Jan. 18, 2024
Abstract INTRODUCTION Hearing loss (HL) has been associated with cognitive decline and dementia. We examined the temporal association between prevalent incident HL change. METHODS A total of 1823 participants (24‐82 years) from Maastricht Aging Study (MAAS) were assessed at baseline, 6 12 years, including pure‐tone audiometry. Linear‐mixed models used to test cognition, adjusted for demographics other dementia risk factors. RESULTS Participants showed a faster in verbal memory, information processing speed, executive function than without HL. Decline was steady baseline years HL, but time‐delayed Having hearing aid did not change associations. DISCUSSION Findings support notion that is factor independent Onset preceded onset decline. Highlights loss. Prevalent For loss, years. observed
Language: Английский
Citations
5
JAMA Otolaryngology–Head & Neck Surgery, Journal Year: 2024, Volume and Issue: 150(5), P. 385 - 385
Published: March 21, 2024
Hearing loss appears to have adverse effects on cognition and increases risk for cognitive impairment. These associations not been thoroughly investigated in the Hispanic Latino population, which faces hearing health disparities.
Language: Английский
Citations
5
Journal of Neurology Neurosurgery & Psychiatry, Journal Year: 2024, Volume and Issue: 95(9), P. 829 - 832
Published: April 3, 2024
Background Hearing loss has been proposed as a modifiable risk factor for dementia. However, the relationship between hearing, neurodegeneration, and cognitive change, extent to which pathological processes such Alzheimer’s disease cerebrovascular influence these relationships, is unclear. Methods Data from 287 adults born in same week of 1946 who underwent baseline pure tone audiometry (mean age=70.6 years) two time point assessment/multimodal brain imaging interval 2.4 were analysed. impairment at was defined average greater than 25 decibels best hearing ear. Rates change whole brain, hippocampal ventricle volume estimated structural MRI using Boundary Shift Integral. Cognition assessed Pre-clinical Cognitive Composite. Regression models performed evaluate how associated with subsequent atrophy decline after adjustment range confounders including β-amyloid deposition white matter hyperintensity volume. Results 111 out participants had impairment. Compared those preserved impaired individuals faster rates atrophy, worse (higher average) predicted atrophy. In impairment, change. All observed relationships independent Conclusions may dementia via pathways distinct typically implicated cognitively unimpaired older adults.
Language: Английский
Citations
5
Journal of the American Geriatrics Society, Journal Year: 2024, Volume and Issue: 72(9), P. 2656 - 2666
Published: June 14, 2024
Identifying risk factors associated with the Motoric Cognitive Risk (MCR) syndrome (a pre-dementia syndrome) can assist in developing reduction strategies and interventions to delay progression dementia. Tailored require comparisons of high- middle-income countries determine if same or different should be targeted. We examined MCR seven Health Retirement Studies harmonized measures.
Language: Английский
Citations
5
Published: July 8, 2024
Neurological diseases have a significant impact on individuals, families, and society. Accurate timely diagnosis is crucial for effective treatment management. However, traditional diagnostic methods are often expensive time-consuming. Recent advancements in bioinspired algorithms offer new possibilities the of neurological diseases. This chapter provides an overview role disease diagnosis. The begins with introduction to algorithms, covering various types commonly used healthcare, such as genetic neural networks, ant colony optimization, particle swarm optimization. applications healthcare explored, emphasizing their contributions medical image analysis, diagnosis, personalized medicine. then focuses providing common current techniques. It reviews limitations, highlighting need alternative approaches. application discussed detail. Genetic optimize feature selection classification demonstrated through case studies research findings. Neural networks explored potential improving accuracy optimization Other also examined selection, clustering model Finally, addresses challenges limitations associated use emphasizes further development this emerging field. Overall, hold great promise advancing field offering opportunities accurate efficient
Language: Английский
Citations
5
Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)
Published: Dec. 4, 2024
Abstract Multisensory decline is common as people age, and aging the primary risk of Alzheimer’s Disease (AD). Recent studies have begun to shed light on possibility that age-related sensory could accelerate AD pathogenesis, or be a prodromal indicator AD. Sensory impairments, specifically in taste smell, often emerge before cognitive symptoms AD, indicating their potential early biomarkers. Olfactory dysfunction has been frequently associated with may offer valuable insights into detection. Hearing impairment significantly but its causal impact progression remains unclear. The review also discusses visual tactile deficits including retinal thinning changes perception, highlighting links disease progression. Focusing molecular mechanisms, explores roles amyloid-β (Aβ) accumulation tau protein pathology bidirectional relationship In summary, evidence presented conclusively supports advocating for an integrated approach understanding decline, enhance detection, implementing preventive strategies, developing therapeutic interventions This underscores significance health addressing neurodegenerative diseases, particularly
Language: Английский
Citations
5